Clonal Deletion Prunes but Does Not Eliminate Self-Specific alpha beta CD8+ T Lymphocytes

It has long been thought that clonal deletion efficiently removes almost all self-specific T cells from the peripheral repertoire. We found that self-peptide MHC-specific CD8+ T cells in the blood of healthy humans were present in frequencies similar to those specific for non-self antigens. For the...

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Veröffentlicht in:	Immunity (Cambridge, Mass.) Mass.), 2015-05, Vol.42 (5), p.929-941
Hauptverfasser:	Yu, Wong, Jiang, Ning, Ebert, Peter JR, Kidd, Brian A, Mueller, Sabina, Lund, Peder J, Juang, Jeremy, Adachi, Keishi, Tse, Tiffany, Birnbaum, Michael E, Newell, Evan W, Wilson, Darrell M, Grotenbreg, Gijsbert M, Valitutti, Salvatore, Quake, Stephen R, Davis, Mark M
Format:	Artikel
Sprache:	eng
Schlagworte:	Hepatitis C virus
Online-Zugang:	Volltext
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