Homodimeric anoctamin-1, but not homodimeric anoctamin-6, is activated by calcium increases mediated by the P2Y1 and P2X7 receptors

The P2X7 receptor (P2X7R) is a ligand-gated ion channel that conducts Na + , K + , and Ca 2+ when activated by extracellular ATP. In various cell types, such as secretory epithelia, the P2X7R is co-expressed with Ca 2+ -dependent Cl − channels of the TMEM16/anoctamin family. Here, we studied whether...

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