Modulation of sterol biosynthesis regulates viral replication and cytokine production in influenza A virus infected human alveolar epithelial cells

•Simvastatin inhibited virus replication and cytokine production by H5N1 virus.•Zometa and FPT inhibitor III inhibited both H5N1 and H1N1 replication.•FPT inhibitor III is a strong immuno-regulator during H5N1 infection.•Protein farnesylation plays a role in cytokine induction by H5N1 virus. Highly...

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Veröffentlicht in:	Antiviral research 2015-07, Vol.119, p.1-7
Hauptverfasser:	Hui, Kenrie P.Y., Kuok, Denise I.T., Kang, Sara S.R., Li, Hung-Sing, Ng, Mandy M.T., Bui, Christine H.T., Peiris, J.S. Malik, Chan, Renee W.Y., Chan, Michael C.W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antiviral Agents - pharmacology Cells, Cultured Cytokine Cytokines - biosynthesis Cytokines - immunology Diphosphonates - pharmacology Epithelial Cells - drug effects Epithelial Cells - metabolism Epithelial Cells - virology Farnesyl transferase inhibitor Humans Imidazoles - pharmacology Influenza A virus Influenza A Virus, H1N1 Subtype - drug effects Influenza A Virus, H1N1 Subtype - immunology Influenza A Virus, H1N1 Subtype - metabolism Influenza A Virus, H5N1 Subtype - drug effects Influenza A Virus, H5N1 Subtype - immunology Influenza A Virus, H5N1 Subtype - physiology Leucine - analogs & derivatives Leucine - pharmacology Naphthalenes - pharmacology Orthomyxoviridae Pulmonary Alveoli - drug effects Pulmonary Alveoli - metabolism Pulmonary Alveoli - virology Simvastatin - pharmacology Statin Sterol biosynthesis Sterols - biosynthesis Virus Replication - drug effects Zometa
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