Sargachromanol G inhibits osteoclastogenesis by suppressing the activation NF-κB and MAPKs in RANKL-induced RAW 264.7 cells

•We study the anti-ostoclastogenesis effect of SG in RANKL-activated RAW 264.7 cells.•SG inhibits osteoclastogenesis from macrophages in vitro.•SG also reduced the RANKL-induced expression of osteoclastic marker genes.•Moreover, SG attenuated RANKL-induced MAPKs and NF-κB activation. Inflammatory cy...

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Veröffentlicht in:	Biochemical and biophysical research communications 2013-05, Vol.434 (4), p.892-897
Hauptverfasser:	Yoon, Weon-Jong, Kim, Kil-Nam, Heo, Soo-Jin, Han, Sang-Chul, Kim, Jihyeon, Ko, Yeong-Jong, Kang, Hee-Kyoung, Yoo, Eun-Sook
Format:	Artikel
Sprache:	eng
Schlagworte:	Acid Phosphatase - genetics Acid Phosphatase - metabolism Animals Benzopyrans - pharmacology Cathepsin K - genetics Cathepsin K - metabolism Cell Line Cell Survival - drug effects Dose-Response Relationship, Drug Gene Expression - drug effects I-kappa B Proteins - metabolism Immunoblotting Isoenzymes - genetics Isoenzymes - metabolism Macrophages - cytology Macrophages - drug effects Macrophages - metabolism MAPK Matrix Metalloproteinase 9 - genetics Matrix Metalloproteinase 9 - metabolism Mice Mitogen-Activated Protein Kinase 8 - metabolism Mitogen-Activated Protein Kinases - metabolism NF-kappa B - metabolism NF-KappaB Inhibitor alpha NF-κB Osteoclastogenesis Osteoclastogenic marker gene Osteoclasts - cytology Osteoclasts - drug effects Osteoclasts - metabolism p38 Mitogen-Activated Protein Kinases - metabolism Phosphorylation - drug effects RANK Ligand - pharmacology RANKL Receptors, Calcitonin - genetics Receptors, Calcitonin - metabolism Reverse Transcriptase Polymerase Chain Reaction Sagachromanol G (SG) Sargassum siliquastrum Tartrate-Resistant Acid Phosphatase
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