Effects of stress early in gestation on hippocampal neurogenesis and glucocorticoid receptor density in pregnant rats

Effects of stress early in gestation on hippocampal neurogenesis and glucocorticoid receptor density in pregnant rats

Highlights • Stress early in gestation increases hippocampal neurogenesis during late pregnancy. • Pregnant females have greater glucocorticoid receptor density in the hippocampus. • Stress decreases CA3 glucocorticoid receptor density in pregnant and virgin females.

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Bibliographische Detailangaben
Veröffentlicht in:Neuroscience 2015-04, Vol.290, p.379-388
Hauptverfasser: Pawluski, J.L, Császár, E, Savage, E, Martinez-Claros, M, Steinbusch, H.W.M, van den Hove, D
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Bromodeoxyuridine
cell proliferation
depression
Female
Hippocampus - physiopathology
Ki-67 Antigen - metabolism
motherhood
Neurogenesis - physiology
Neurology
pregnancy
Pregnancy - physiology
Random Allocation
Rats, Sprague-Dawley
Receptors, Glucocorticoid - metabolism
reproduction
Stress, Psychological - physiopathology
Time Factors
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Beschreibung
Zusammenfassung:Highlights • Stress early in gestation increases hippocampal neurogenesis during late pregnancy. • Pregnant females have greater glucocorticoid receptor density in the hippocampus. • Stress decreases CA3 glucocorticoid receptor density in pregnant and virgin females.
ISSN:0306-4522
1873-7544
DOI:10.1016/j.neuroscience.2015.01.048