The role of APCDD1 in epithelial rearrangement in tooth morphogenesis
Adenomatosis polyposis coli downregulated 1 (APCDD1), a negative regulator of Wnt signaling, was examined to understand detailed mechanisms underlying Wnt signaling tooth development. In situ hybridization showed that Apcdd1 was expressed in the condensed mesenchyme at the bud stage, and in the inne...
Gespeichert in:
| Veröffentlicht in: | Histochemistry and cell biology 2015-10, Vol.144 (4), p.377-387 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 387 |
|---|---|
| container_issue | 4 |
| container_start_page | 377 |
| container_title | Histochemistry and cell biology |
| container_volume | 144 |
| creator | Neupane, Sanjiv Sohn, Wern-Joo Gwon, Gi-Jeong Kim, Ki-Rim Lee, Sanggyu An, Chang-Hyeon Suh, Jo-Young Shin, Hong-In Yamamoto, Hitoshi Cho, Sung-Won Lee, Youngkyun Kim, Jae-Young |
| description | Adenomatosis polyposis coli downregulated 1 (APCDD1), a negative regulator of Wnt signaling, was examined to understand detailed mechanisms underlying Wnt signaling tooth development. In situ hybridization showed that
Apcdd1
was expressed in the condensed mesenchyme at the bud stage, and in the inner enamel epithelium (IEE), including enamel knot (EK) at the cap stage. In vitro organ cultivation by using
Apcdd1
antisense oligodeoxynucleotides was performed at E13.5 for 2 days to define the developmental functions of APCDD1 during tooth development. Analysis of histogenesis and cellular events such as cell adhesion, proliferation, apoptosis and epithelial rearrangement after
Apcdd1
knockdown showed altered morphogenesis of the tooth germ with decreased cell proliferation and altered localization of cell adhesion molecules. Actin filament staining and 1,1′-dioctadecyl-3,3,3′,3′-tetramethylindocarbocyanine perchlorate (DiI) labeling of IEE cells showed that
Apcdd1
knockdown enhanced epithelial rearrangement in the IEE and EK. To understand the precise signaling regulations of Apcdd1, we evaluated the altered expression patterns of signaling molecules, related with Wnt and enamel knot signalings using RT-qPCR. Tooth germs at cap stage were transplanted into the kidney capsules and were allowed to develop into calcified teeth for 3 weeks.
Apcdd1
knockdown increased the number of ectopic cusps on the mesial side of the tooth. Our results suggested that APCDD1 modulates the gene expression of Wnt- and EK-related signaling molecules at the cap stage of tooth development, and is involved in tooth cusp patterning by modulating the epithelial rearrangement in the IEE. |
| doi_str_mv | 10.1007/s00418-015-1345-z |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1732828759</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3811458091</sourcerecordid><originalsourceid>FETCH-LOGICAL-c405t-a513f374586eb979252b0af2337009718b709dcc1d9a8aa95087a9f98969c16d3</originalsourceid><addsrcrecordid>eNqNkU1rGzEQhkVpaJyPH9BLWeill21m9LHSHI2dpAVDckggNyGvtfGG3ZUrrQ_xr68cJ6UUCjkNzDzzDvO-jH1G-I4A-iIBSDQloCpRSFXuPrAJSsFLRHr4yCZA0pRV7hyzk5SeIIPE-Sd2zCvUgLKasMu7tS9i6HwRmmJ6O5vPsWiHwm_ace271nVF9C5GNzz63g_jfjaGMK6LPsTNOjz6wac2nbGjxnXJn7_WU3Z_dXk3-1Eubq5_zqaLspagxtIpFI3QUpnKL0kTV3wJruFCaADSaJYaaFXXuCJnnCMFRjtqyFBFNVYrccq-HXQ3Mfza-jTavk217zo3-LBNFrXghhut6B0oCpISSGX06z_oU9jGIT_yQmmuCU2m8EDVMaQUfWM3se1dfLYIdh-HPcRhs8t2H4fd5Z0vr8rbZe9Xfzbe_M8APwApj7LH8a_T_1X9DWvkkpI</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1713727918</pqid></control><display><type>article</type><title>The role of APCDD1 in epithelial rearrangement in tooth morphogenesis</title><source>MEDLINE</source><source>Springer Nature - Complete Springer Journals</source><creator>Neupane, Sanjiv ; Sohn, Wern-Joo ; Gwon, Gi-Jeong ; Kim, Ki-Rim ; Lee, Sanggyu ; An, Chang-Hyeon ; Suh, Jo-Young ; Shin, Hong-In ; Yamamoto, Hitoshi ; Cho, Sung-Won ; Lee, Youngkyun ; Kim, Jae-Young</creator><creatorcontrib>Neupane, Sanjiv ; Sohn, Wern-Joo ; Gwon, Gi-Jeong ; Kim, Ki-Rim ; Lee, Sanggyu ; An, Chang-Hyeon ; Suh, Jo-Young ; Shin, Hong-In ; Yamamoto, Hitoshi ; Cho, Sung-Won ; Lee, Youngkyun ; Kim, Jae-Young</creatorcontrib><description>Adenomatosis polyposis coli downregulated 1 (APCDD1), a negative regulator of Wnt signaling, was examined to understand detailed mechanisms underlying Wnt signaling tooth development. In situ hybridization showed that
Apcdd1
was expressed in the condensed mesenchyme at the bud stage, and in the inner enamel epithelium (IEE), including enamel knot (EK) at the cap stage. In vitro organ cultivation by using
Apcdd1
antisense oligodeoxynucleotides was performed at E13.5 for 2 days to define the developmental functions of APCDD1 during tooth development. Analysis of histogenesis and cellular events such as cell adhesion, proliferation, apoptosis and epithelial rearrangement after
Apcdd1
knockdown showed altered morphogenesis of the tooth germ with decreased cell proliferation and altered localization of cell adhesion molecules. Actin filament staining and 1,1′-dioctadecyl-3,3,3′,3′-tetramethylindocarbocyanine perchlorate (DiI) labeling of IEE cells showed that
Apcdd1
knockdown enhanced epithelial rearrangement in the IEE and EK. To understand the precise signaling regulations of Apcdd1, we evaluated the altered expression patterns of signaling molecules, related with Wnt and enamel knot signalings using RT-qPCR. Tooth germs at cap stage were transplanted into the kidney capsules and were allowed to develop into calcified teeth for 3 weeks.
Apcdd1
knockdown increased the number of ectopic cusps on the mesial side of the tooth. Our results suggested that APCDD1 modulates the gene expression of Wnt- and EK-related signaling molecules at the cap stage of tooth development, and is involved in tooth cusp patterning by modulating the epithelial rearrangement in the IEE.</description><identifier>ISSN: 0948-6143</identifier><identifier>EISSN: 1432-119X</identifier><identifier>DOI: 10.1007/s00418-015-1345-z</identifier><identifier>PMID: 26170146</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Animals ; Biochemistry ; Biomedical and Life Sciences ; Biomedicine ; Cell adhesion & migration ; Cell Adhesion Molecules - metabolism ; Cell Biology ; Cell Proliferation ; Developmental Biology ; Epithelial Cells - metabolism ; Gene expression ; Gene Expression Regulation, Developmental ; Gene Knockdown Techniques ; Gestational Age ; Intracellular Signaling Peptides and Proteins - genetics ; Intracellular Signaling Peptides and Proteins - metabolism ; Membrane Proteins - genetics ; Membrane Proteins - metabolism ; Mice ; Molar - embryology ; Molar - metabolism ; Morphogenesis ; Odontogenesis ; Oligonucleotides, Antisense - genetics ; Oligonucleotides, Antisense - metabolism ; Original Paper ; Teeth ; Tissue Culture Techniques ; Wnt Signaling Pathway</subject><ispartof>Histochemistry and cell biology, 2015-10, Vol.144 (4), p.377-387</ispartof><rights>Springer-Verlag Berlin Heidelberg 2015</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c405t-a513f374586eb979252b0af2337009718b709dcc1d9a8aa95087a9f98969c16d3</citedby><cites>FETCH-LOGICAL-c405t-a513f374586eb979252b0af2337009718b709dcc1d9a8aa95087a9f98969c16d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00418-015-1345-z$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00418-015-1345-z$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,778,782,27911,27912,41475,42544,51306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26170146$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Neupane, Sanjiv</creatorcontrib><creatorcontrib>Sohn, Wern-Joo</creatorcontrib><creatorcontrib>Gwon, Gi-Jeong</creatorcontrib><creatorcontrib>Kim, Ki-Rim</creatorcontrib><creatorcontrib>Lee, Sanggyu</creatorcontrib><creatorcontrib>An, Chang-Hyeon</creatorcontrib><creatorcontrib>Suh, Jo-Young</creatorcontrib><creatorcontrib>Shin, Hong-In</creatorcontrib><creatorcontrib>Yamamoto, Hitoshi</creatorcontrib><creatorcontrib>Cho, Sung-Won</creatorcontrib><creatorcontrib>Lee, Youngkyun</creatorcontrib><creatorcontrib>Kim, Jae-Young</creatorcontrib><title>The role of APCDD1 in epithelial rearrangement in tooth morphogenesis</title><title>Histochemistry and cell biology</title><addtitle>Histochem Cell Biol</addtitle><addtitle>Histochem Cell Biol</addtitle><description>Adenomatosis polyposis coli downregulated 1 (APCDD1), a negative regulator of Wnt signaling, was examined to understand detailed mechanisms underlying Wnt signaling tooth development. In situ hybridization showed that
Apcdd1
was expressed in the condensed mesenchyme at the bud stage, and in the inner enamel epithelium (IEE), including enamel knot (EK) at the cap stage. In vitro organ cultivation by using
Apcdd1
antisense oligodeoxynucleotides was performed at E13.5 for 2 days to define the developmental functions of APCDD1 during tooth development. Analysis of histogenesis and cellular events such as cell adhesion, proliferation, apoptosis and epithelial rearrangement after
Apcdd1
knockdown showed altered morphogenesis of the tooth germ with decreased cell proliferation and altered localization of cell adhesion molecules. Actin filament staining and 1,1′-dioctadecyl-3,3,3′,3′-tetramethylindocarbocyanine perchlorate (DiI) labeling of IEE cells showed that
Apcdd1
knockdown enhanced epithelial rearrangement in the IEE and EK. To understand the precise signaling regulations of Apcdd1, we evaluated the altered expression patterns of signaling molecules, related with Wnt and enamel knot signalings using RT-qPCR. Tooth germs at cap stage were transplanted into the kidney capsules and were allowed to develop into calcified teeth for 3 weeks.
Apcdd1
knockdown increased the number of ectopic cusps on the mesial side of the tooth. Our results suggested that APCDD1 modulates the gene expression of Wnt- and EK-related signaling molecules at the cap stage of tooth development, and is involved in tooth cusp patterning by modulating the epithelial rearrangement in the IEE.</description><subject>Animals</subject><subject>Biochemistry</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cell adhesion & migration</subject><subject>Cell Adhesion Molecules - metabolism</subject><subject>Cell Biology</subject><subject>Cell Proliferation</subject><subject>Developmental Biology</subject><subject>Epithelial Cells - metabolism</subject><subject>Gene expression</subject><subject>Gene Expression Regulation, Developmental</subject><subject>Gene Knockdown Techniques</subject><subject>Gestational Age</subject><subject>Intracellular Signaling Peptides and Proteins - genetics</subject><subject>Intracellular Signaling Peptides and Proteins - metabolism</subject><subject>Membrane Proteins - genetics</subject><subject>Membrane Proteins - metabolism</subject><subject>Mice</subject><subject>Molar - embryology</subject><subject>Molar - metabolism</subject><subject>Morphogenesis</subject><subject>Odontogenesis</subject><subject>Oligonucleotides, Antisense - genetics</subject><subject>Oligonucleotides, Antisense - metabolism</subject><subject>Original Paper</subject><subject>Teeth</subject><subject>Tissue Culture Techniques</subject><subject>Wnt Signaling Pathway</subject><issn>0948-6143</issn><issn>1432-119X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqNkU1rGzEQhkVpaJyPH9BLWeill21m9LHSHI2dpAVDckggNyGvtfGG3ZUrrQ_xr68cJ6UUCjkNzDzzDvO-jH1G-I4A-iIBSDQloCpRSFXuPrAJSsFLRHr4yCZA0pRV7hyzk5SeIIPE-Sd2zCvUgLKasMu7tS9i6HwRmmJ6O5vPsWiHwm_ace271nVF9C5GNzz63g_jfjaGMK6LPsTNOjz6wac2nbGjxnXJn7_WU3Z_dXk3-1Eubq5_zqaLspagxtIpFI3QUpnKL0kTV3wJruFCaADSaJYaaFXXuCJnnCMFRjtqyFBFNVYrccq-HXQ3Mfza-jTavk217zo3-LBNFrXghhut6B0oCpISSGX06z_oU9jGIT_yQmmuCU2m8EDVMaQUfWM3se1dfLYIdh-HPcRhs8t2H4fd5Z0vr8rbZe9Xfzbe_M8APwApj7LH8a_T_1X9DWvkkpI</recordid><startdate>20151001</startdate><enddate>20151001</enddate><creator>Neupane, Sanjiv</creator><creator>Sohn, Wern-Joo</creator><creator>Gwon, Gi-Jeong</creator><creator>Kim, Ki-Rim</creator><creator>Lee, Sanggyu</creator><creator>An, Chang-Hyeon</creator><creator>Suh, Jo-Young</creator><creator>Shin, Hong-In</creator><creator>Yamamoto, Hitoshi</creator><creator>Cho, Sung-Won</creator><creator>Lee, Youngkyun</creator><creator>Kim, Jae-Young</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7RV</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20151001</creationdate><title>The role of APCDD1 in epithelial rearrangement in tooth morphogenesis</title><author>Neupane, Sanjiv ; Sohn, Wern-Joo ; Gwon, Gi-Jeong ; Kim, Ki-Rim ; Lee, Sanggyu ; An, Chang-Hyeon ; Suh, Jo-Young ; Shin, Hong-In ; Yamamoto, Hitoshi ; Cho, Sung-Won ; Lee, Youngkyun ; Kim, Jae-Young</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c405t-a513f374586eb979252b0af2337009718b709dcc1d9a8aa95087a9f98969c16d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Animals</topic><topic>Biochemistry</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Cell adhesion & migration</topic><topic>Cell Adhesion Molecules - metabolism</topic><topic>Cell Biology</topic><topic>Cell Proliferation</topic><topic>Developmental Biology</topic><topic>Epithelial Cells - metabolism</topic><topic>Gene expression</topic><topic>Gene Expression Regulation, Developmental</topic><topic>Gene Knockdown Techniques</topic><topic>Gestational Age</topic><topic>Intracellular Signaling Peptides and Proteins - genetics</topic><topic>Intracellular Signaling Peptides and Proteins - metabolism</topic><topic>Membrane Proteins - genetics</topic><topic>Membrane Proteins - metabolism</topic><topic>Mice</topic><topic>Molar - embryology</topic><topic>Molar - metabolism</topic><topic>Morphogenesis</topic><topic>Odontogenesis</topic><topic>Oligonucleotides, Antisense - genetics</topic><topic>Oligonucleotides, Antisense - metabolism</topic><topic>Original Paper</topic><topic>Teeth</topic><topic>Tissue Culture Techniques</topic><topic>Wnt Signaling Pathway</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Neupane, Sanjiv</creatorcontrib><creatorcontrib>Sohn, Wern-Joo</creatorcontrib><creatorcontrib>Gwon, Gi-Jeong</creatorcontrib><creatorcontrib>Kim, Ki-Rim</creatorcontrib><creatorcontrib>Lee, Sanggyu</creatorcontrib><creatorcontrib>An, Chang-Hyeon</creatorcontrib><creatorcontrib>Suh, Jo-Young</creatorcontrib><creatorcontrib>Shin, Hong-In</creatorcontrib><creatorcontrib>Yamamoto, Hitoshi</creatorcontrib><creatorcontrib>Cho, Sung-Won</creatorcontrib><creatorcontrib>Lee, Youngkyun</creatorcontrib><creatorcontrib>Kim, Jae-Young</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Histochemistry and cell biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Neupane, Sanjiv</au><au>Sohn, Wern-Joo</au><au>Gwon, Gi-Jeong</au><au>Kim, Ki-Rim</au><au>Lee, Sanggyu</au><au>An, Chang-Hyeon</au><au>Suh, Jo-Young</au><au>Shin, Hong-In</au><au>Yamamoto, Hitoshi</au><au>Cho, Sung-Won</au><au>Lee, Youngkyun</au><au>Kim, Jae-Young</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The role of APCDD1 in epithelial rearrangement in tooth morphogenesis</atitle><jtitle>Histochemistry and cell biology</jtitle><stitle>Histochem Cell Biol</stitle><addtitle>Histochem Cell Biol</addtitle><date>2015-10-01</date><risdate>2015</risdate><volume>144</volume><issue>4</issue><spage>377</spage><epage>387</epage><pages>377-387</pages><issn>0948-6143</issn><eissn>1432-119X</eissn><abstract>Adenomatosis polyposis coli downregulated 1 (APCDD1), a negative regulator of Wnt signaling, was examined to understand detailed mechanisms underlying Wnt signaling tooth development. In situ hybridization showed that
Apcdd1
was expressed in the condensed mesenchyme at the bud stage, and in the inner enamel epithelium (IEE), including enamel knot (EK) at the cap stage. In vitro organ cultivation by using
Apcdd1
antisense oligodeoxynucleotides was performed at E13.5 for 2 days to define the developmental functions of APCDD1 during tooth development. Analysis of histogenesis and cellular events such as cell adhesion, proliferation, apoptosis and epithelial rearrangement after
Apcdd1
knockdown showed altered morphogenesis of the tooth germ with decreased cell proliferation and altered localization of cell adhesion molecules. Actin filament staining and 1,1′-dioctadecyl-3,3,3′,3′-tetramethylindocarbocyanine perchlorate (DiI) labeling of IEE cells showed that
Apcdd1
knockdown enhanced epithelial rearrangement in the IEE and EK. To understand the precise signaling regulations of Apcdd1, we evaluated the altered expression patterns of signaling molecules, related with Wnt and enamel knot signalings using RT-qPCR. Tooth germs at cap stage were transplanted into the kidney capsules and were allowed to develop into calcified teeth for 3 weeks.
Apcdd1
knockdown increased the number of ectopic cusps on the mesial side of the tooth. Our results suggested that APCDD1 modulates the gene expression of Wnt- and EK-related signaling molecules at the cap stage of tooth development, and is involved in tooth cusp patterning by modulating the epithelial rearrangement in the IEE.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>26170146</pmid><doi>10.1007/s00418-015-1345-z</doi><tpages>11</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0948-6143 |
| ispartof | Histochemistry and cell biology, 2015-10, Vol.144 (4), p.377-387 |
| issn | 0948-6143 1432-119X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1732828759 |
| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Animals Biochemistry Biomedical and Life Sciences Biomedicine Cell adhesion & migration Cell Adhesion Molecules - metabolism Cell Biology Cell Proliferation Developmental Biology Epithelial Cells - metabolism Gene expression Gene Expression Regulation, Developmental Gene Knockdown Techniques Gestational Age Intracellular Signaling Peptides and Proteins - genetics Intracellular Signaling Peptides and Proteins - metabolism Membrane Proteins - genetics Membrane Proteins - metabolism Mice Molar - embryology Molar - metabolism Morphogenesis Odontogenesis Oligonucleotides, Antisense - genetics Oligonucleotides, Antisense - metabolism Original Paper Teeth Tissue Culture Techniques Wnt Signaling Pathway |
| title | The role of APCDD1 in epithelial rearrangement in tooth morphogenesis |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-15T19%3A39%3A48IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20role%20of%20APCDD1%20in%20epithelial%20rearrangement%20in%20tooth%20morphogenesis&rft.jtitle=Histochemistry%20and%20cell%20biology&rft.au=Neupane,%20Sanjiv&rft.date=2015-10-01&rft.volume=144&rft.issue=4&rft.spage=377&rft.epage=387&rft.pages=377-387&rft.issn=0948-6143&rft.eissn=1432-119X&rft_id=info:doi/10.1007/s00418-015-1345-z&rft_dat=%3Cproquest_cross%3E3811458091%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1713727918&rft_id=info:pmid/26170146&rfr_iscdi=true |