Mechanism-Based QSAR Modeling of Skin Sensitization

Many chemicals can induce skin sensitization, and there is a pressing need for non-animal methods to give a quantitative indication of potency. Using two large published data sets of skin sensitizers, we have allocated each sensitizing chemical to one of 10 mechanistic categories and then developed...

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Veröffentlicht in:	Chemical research in toxicology 2015-10, Vol.28 (10), p.1975-1986
Hauptverfasser:	Dearden, J. C, Hewitt, M, Roberts, D. W, Enoch, S. J, Rowe, P. H, Przybylak, K. R, Vaughan-Williams, G. D, Smith, M. L, Pillai, G. G, Katritzky, A. R
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Models, Theoretical Organic Chemicals - chemistry Organic Chemicals - toxicity Quantitative Structure-Activity Relationship Skin - drug effects Skin - metabolism
Online-Zugang:	Volltext
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