Wip1 phosphatase in breast cancer

Understanding the factors contributing to tumor initiation, progression and evolution is of paramount significance. Among them, wild-type p53-induced phosphatase 1 (Wip1) is emerging as an important oncogene by virtue of its negative control on several key tumor suppressor pathways. Originally disco...

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Veröffentlicht in:	Oncogene 2015-08, Vol.34 (34), p.4429-4438
Hauptverfasser:	Emelyanov, A, Bulavin, D V
Format:	Artikel
Sprache:	eng
Schlagworte:	631/67/1347 Apoptosis Breast - growth & development Breast cancer Breast Neoplasms - etiology Cell Biology Cytidine Deaminase - genetics Development and progression DNA Damage Female Genes, BRCA2 Genes, p53 Genetic aspects Health aspects Heterochromatin Human Genetics Humans Innovations Internal Medicine Medicine Medicine & Public Health Minor Histocompatibility Antigens Molecular targeted therapy Mutation Oncogenes Oncology p53 Protein Phosphatase Phosphoprotein Phosphatases - genetics Phosphoprotein Phosphatases - physiology Protein Phosphatase 2C Receptor, ErbB-2 - physiology review Tumor proteins Tumor suppressor genes Tumorigenesis Tumors Wnt1 Protein - physiology
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