Effects of differentiation on purinergic and neurotensin-mediated calcium signaling in human HT-29 colon cancer cells

•We examined Ca2+ signaling in differentiated colon cancer cells.•Parameters including peak cytosolic free Ca2+ after activation were assessed.•Differentiated colon cancer cells exhibited remodeled NT mediated Ca2+ signaling.•NT Ca2+ signal remodeling was not related to changes in NT receptor mRNA l...

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Veröffentlicht in:	Biochemical and biophysical research communications 2013-09, Vol.439 (1), p.35-39
Hauptverfasser:	Chowdhury, Mohammad A., Peters, Amelia A., Roberts-Thomson, Sarah J., Monteith, Gregory R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphate - metabolism Butyrates - pharmacology Calcium - metabolism Calcium signaling Calcium Signaling - drug effects Cell Differentiation Colon cancer Colonic Neoplasms - metabolism Cytosol - metabolism Differentiation Dose-Response Relationship, Drug Gene Expression Regulation, Neoplastic HT29 Cells Humans Neurotensin - metabolism Neurotensin receptors Purinergic receptors Receptors, Neurotensin - metabolism Receptors, Purinergic - metabolism RNA, Messenger - metabolism Signal Transduction
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