Alternative solutions and new scenarios for translesion DNA synthesis by human PrimPol

PrimPol is a recently described DNA polymerase that has the virtue of initiating DNA synthesis. In addition of being a sensu stricto DNA primase, PrimPol's polymerase activity has a large capacity to tolerate different kind of lesions. The different strategies used by PrimPol for DNA damage tol...

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Veröffentlicht in:	DNA repair 2015-05, Vol.29, p.127-138
Hauptverfasser:	Martínez-Jiménez, María I., García-Gómez, Sara, Bebenek, Katarzyna, Sastre-Moreno, Guillermo, Calvo, Patricia A., Díaz-Talavera, Alberto, Kunkel, Thomas A., Blanco, Luis
Format:	Artikel
Sprache:	eng
Schlagworte:	8oxoG Cations DNA - biosynthesis DNA - metabolism DNA Damage DNA polymerase DNA primase DNA Primase - chemistry DNA Primase - metabolism DNA Repair DNA Replication DNA-Directed DNA Polymerase - chemistry DNA-Directed DNA Polymerase - metabolism Humans Lesion bypass Manganese - chemistry Multifunctional Enzymes - chemistry Multifunctional Enzymes - metabolism Nucleic Acid Conformation PrimPol Translesion synthesis
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