Using Opioid Receptors to Expand the Chemogenetic and Optogenetic Toolbox

In this issue of Neuron, innovative new modifications to opioid receptors are used to expand the tools available to modulate neuronal activity. Vardy et al. (2015) describe a new “DREADD” chemogenetic tool based on the inhibitory κ opioid receptor (KORD) that can be used in conjunction with already-...

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Veröffentlicht in:	Neuron (Cambridge, Mass.) Mass.), 2015-05, Vol.86 (4), p.853-855
Hauptverfasser:	Damez-Werno, Diane M., Kenny, Paul J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Analgesics, Opioid - pharmacology Animals Behavior Behavior, Animal - drug effects Binding sites Brain Diterpenes - pharmacology GABAergic Neurons - drug effects Ligands Light Narcotics Neurons Neurons - drug effects Optogenetics Receptors, Opioid, kappa - metabolism Receptors, Opioid, mu - metabolism Signal Transduction - drug effects
Online-Zugang:	Volltext
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