Post-training corticosterone inhibits the return of fear evoked by platform stress and a subthreshold conditioning procedure in Sprague–Dawley rats
The return of fear is an important issue in anxiety disorder research. Each time a fear memory is reactivated, it may further strengthen overactivation of the fear circuit, which may contribute to long-term maintenance of the fear memory. Recent evidence indicates that glucocorticoids may help atten...
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Veröffentlicht in: | Pharmacology, biochemistry and behavior biochemistry and behavior, 2015-06, Vol.133, p.43-50 |
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creator | Xing, Xiaoli Wang, Hongbo Zhang, Lili Bai, Yunjing Liang, Jing Liu, Zhengkui Zheng, Xigeng |
description | The return of fear is an important issue in anxiety disorder research. Each time a fear memory is reactivated, it may further strengthen overactivation of the fear circuit, which may contribute to long-term maintenance of the fear memory. Recent evidence indicates that glucocorticoids may help attenuate pathological fear, but its role in the return of fear is unclear. In the present study, systemic corticosterone (CORT; 25mg/kg) administration 1h after fear conditioning did not impair the consolidation process but significantly suppressed the return of fear evoked by a subthreshold conditioning (SC) procedure and elevated platform (EP) stress. Compared with the SC-induced return of fear, acute stress-induced return was state-dependent. In addition, post-training CORT treatment increased the adrenocorticotropic response after EP stress, which indicates that the drug-induced suppression of the return of fear may possibly derive from its regulation effect of the hypothalamic–pituitary–adrenal axis reactivity to stress. These results suggest that post-training CORT administration may help inhibit the return of fear evoked by EP or SC stress. The possible mechanisms involved in the high-dose CORT-induced suppression of the SC- and EP-induced return of fear are discussed.
•Both SC procedure and EP stress induced the return of fear.•CORT treatment suppressed the return of fear evoked by SC or EP stress.•Post-training CORT treatment increased ACTH response after EP stress. |
doi_str_mv | 10.1016/j.pbb.2015.03.013 |
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•Both SC procedure and EP stress induced the return of fear.•CORT treatment suppressed the return of fear evoked by SC or EP stress.•Post-training CORT treatment increased ACTH response after EP stress.</description><identifier>ISSN: 0091-3057</identifier><identifier>EISSN: 1873-5177</identifier><identifier>DOI: 10.1016/j.pbb.2015.03.013</identifier><identifier>PMID: 25818040</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adrenocorticotropic Hormone - blood ; Animals ; Conditioning, Classical - drug effects ; Corticosterone ; Corticosterone - blood ; Corticosterone - pharmacology ; Extinction ; Extinction, Psychological - drug effects ; Fear - drug effects ; Fear conditioning ; Fear return ; Male ; Rats ; Rats, Sprague-Dawley ; Stress, Psychological - psychology ; Subthreshold conditioning procedure</subject><ispartof>Pharmacology, biochemistry and behavior, 2015-06, Vol.133, p.43-50</ispartof><rights>2015 Elsevier Inc.</rights><rights>Copyright © 2015 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c386t-c86815ed67432d73ce4500beecbf21ca5858a3102a49e9190d9e3beaebedf6fb3</citedby><cites>FETCH-LOGICAL-c386t-c86815ed67432d73ce4500beecbf21ca5858a3102a49e9190d9e3beaebedf6fb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0091305715000994$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25818040$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Xing, Xiaoli</creatorcontrib><creatorcontrib>Wang, Hongbo</creatorcontrib><creatorcontrib>Zhang, Lili</creatorcontrib><creatorcontrib>Bai, Yunjing</creatorcontrib><creatorcontrib>Liang, Jing</creatorcontrib><creatorcontrib>Liu, Zhengkui</creatorcontrib><creatorcontrib>Zheng, Xigeng</creatorcontrib><title>Post-training corticosterone inhibits the return of fear evoked by platform stress and a subthreshold conditioning procedure in Sprague–Dawley rats</title><title>Pharmacology, biochemistry and behavior</title><addtitle>Pharmacol Biochem Behav</addtitle><description>The return of fear is an important issue in anxiety disorder research. Each time a fear memory is reactivated, it may further strengthen overactivation of the fear circuit, which may contribute to long-term maintenance of the fear memory. Recent evidence indicates that glucocorticoids may help attenuate pathological fear, but its role in the return of fear is unclear. In the present study, systemic corticosterone (CORT; 25mg/kg) administration 1h after fear conditioning did not impair the consolidation process but significantly suppressed the return of fear evoked by a subthreshold conditioning (SC) procedure and elevated platform (EP) stress. Compared with the SC-induced return of fear, acute stress-induced return was state-dependent. In addition, post-training CORT treatment increased the adrenocorticotropic response after EP stress, which indicates that the drug-induced suppression of the return of fear may possibly derive from its regulation effect of the hypothalamic–pituitary–adrenal axis reactivity to stress. These results suggest that post-training CORT administration may help inhibit the return of fear evoked by EP or SC stress. The possible mechanisms involved in the high-dose CORT-induced suppression of the SC- and EP-induced return of fear are discussed.
•Both SC procedure and EP stress induced the return of fear.•CORT treatment suppressed the return of fear evoked by SC or EP stress.•Post-training CORT treatment increased ACTH response after EP stress.</description><subject>Adrenocorticotropic Hormone - blood</subject><subject>Animals</subject><subject>Conditioning, Classical - drug effects</subject><subject>Corticosterone</subject><subject>Corticosterone - blood</subject><subject>Corticosterone - pharmacology</subject><subject>Extinction</subject><subject>Extinction, Psychological - drug effects</subject><subject>Fear - drug effects</subject><subject>Fear conditioning</subject><subject>Fear return</subject><subject>Male</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Stress, Psychological - psychology</subject><subject>Subthreshold conditioning procedure</subject><issn>0091-3057</issn><issn>1873-5177</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUuO1DAQhi0EYpqBA7BBXrJJKMdx4ogVmuEljQQSsLb8qEy7ScfBdgb1jjsgLshJcNMDS1hZZX31Val-Qh4zqBmw7tmuXoypG2CiBl4D43fIhsmeV4L1_V2yARhYxUH0Z-RBSjsAaJuuv0_OGiGZhBY25Mf7kHKVo_azn6-pDTF7W74whhmpn7fe-Jxo3iKNmNc40zDSEXWkeBM-o6PmQJdJ5zHEPU05YkpUz45qmlaTt6XehskV7-x89uH3kCUGi26NRz_9sER9veLPb98v9dcJDzTqnB6Se6OeEj66fc_Jp1cvP168qa7evX578eKqslx2ubKyk0yg6_qWN67nFlsBYBCtGRtmtZBCas6g0e2AAxvADcgNajToxm40_Jw8PXnLSl9WTFntfbI4TXrGsCbFet7IppUD_B_tJAyi60AWlJ1QG0NKEUe1RL_X8aAYqGNwaqdKcOoYnAKuSnCl58mtfjV7dH87_iRVgOcnAMs9bjxGlazHuRzSR7RZueD_of8FtDit4Q</recordid><startdate>201506</startdate><enddate>201506</enddate><creator>Xing, Xiaoli</creator><creator>Wang, Hongbo</creator><creator>Zhang, Lili</creator><creator>Bai, Yunjing</creator><creator>Liang, Jing</creator><creator>Liu, Zhengkui</creator><creator>Zheng, Xigeng</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7QG</scope><scope>7TK</scope></search><sort><creationdate>201506</creationdate><title>Post-training corticosterone inhibits the return of fear evoked by platform stress and a subthreshold conditioning procedure in Sprague–Dawley rats</title><author>Xing, Xiaoli ; Wang, Hongbo ; Zhang, Lili ; Bai, Yunjing ; Liang, Jing ; Liu, Zhengkui ; Zheng, Xigeng</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c386t-c86815ed67432d73ce4500beecbf21ca5858a3102a49e9190d9e3beaebedf6fb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adrenocorticotropic Hormone - blood</topic><topic>Animals</topic><topic>Conditioning, Classical - drug effects</topic><topic>Corticosterone</topic><topic>Corticosterone - blood</topic><topic>Corticosterone - pharmacology</topic><topic>Extinction</topic><topic>Extinction, Psychological - drug effects</topic><topic>Fear - drug effects</topic><topic>Fear conditioning</topic><topic>Fear return</topic><topic>Male</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Stress, Psychological - psychology</topic><topic>Subthreshold conditioning procedure</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Xing, Xiaoli</creatorcontrib><creatorcontrib>Wang, Hongbo</creatorcontrib><creatorcontrib>Zhang, Lili</creatorcontrib><creatorcontrib>Bai, Yunjing</creatorcontrib><creatorcontrib>Liang, Jing</creatorcontrib><creatorcontrib>Liu, Zhengkui</creatorcontrib><creatorcontrib>Zheng, Xigeng</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Animal Behavior Abstracts</collection><collection>Neurosciences Abstracts</collection><jtitle>Pharmacology, biochemistry and behavior</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Xing, Xiaoli</au><au>Wang, Hongbo</au><au>Zhang, Lili</au><au>Bai, Yunjing</au><au>Liang, Jing</au><au>Liu, Zhengkui</au><au>Zheng, Xigeng</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Post-training corticosterone inhibits the return of fear evoked by platform stress and a subthreshold conditioning procedure in Sprague–Dawley rats</atitle><jtitle>Pharmacology, biochemistry and behavior</jtitle><addtitle>Pharmacol Biochem Behav</addtitle><date>2015-06</date><risdate>2015</risdate><volume>133</volume><spage>43</spage><epage>50</epage><pages>43-50</pages><issn>0091-3057</issn><eissn>1873-5177</eissn><abstract>The return of fear is an important issue in anxiety disorder research. Each time a fear memory is reactivated, it may further strengthen overactivation of the fear circuit, which may contribute to long-term maintenance of the fear memory. Recent evidence indicates that glucocorticoids may help attenuate pathological fear, but its role in the return of fear is unclear. In the present study, systemic corticosterone (CORT; 25mg/kg) administration 1h after fear conditioning did not impair the consolidation process but significantly suppressed the return of fear evoked by a subthreshold conditioning (SC) procedure and elevated platform (EP) stress. Compared with the SC-induced return of fear, acute stress-induced return was state-dependent. In addition, post-training CORT treatment increased the adrenocorticotropic response after EP stress, which indicates that the drug-induced suppression of the return of fear may possibly derive from its regulation effect of the hypothalamic–pituitary–adrenal axis reactivity to stress. These results suggest that post-training CORT administration may help inhibit the return of fear evoked by EP or SC stress. The possible mechanisms involved in the high-dose CORT-induced suppression of the SC- and EP-induced return of fear are discussed.
•Both SC procedure and EP stress induced the return of fear.•CORT treatment suppressed the return of fear evoked by SC or EP stress.•Post-training CORT treatment increased ACTH response after EP stress.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>25818040</pmid><doi>10.1016/j.pbb.2015.03.013</doi><tpages>8</tpages></addata></record> |
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subjects | Adrenocorticotropic Hormone - blood Animals Conditioning, Classical - drug effects Corticosterone Corticosterone - blood Corticosterone - pharmacology Extinction Extinction, Psychological - drug effects Fear - drug effects Fear conditioning Fear return Male Rats Rats, Sprague-Dawley Stress, Psychological - psychology Subthreshold conditioning procedure |
title | Post-training corticosterone inhibits the return of fear evoked by platform stress and a subthreshold conditioning procedure in Sprague–Dawley rats |
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