Post-training corticosterone inhibits the return of fear evoked by platform stress and a subthreshold conditioning procedure in Sprague–Dawley rats

The return of fear is an important issue in anxiety disorder research. Each time a fear memory is reactivated, it may further strengthen overactivation of the fear circuit, which may contribute to long-term maintenance of the fear memory. Recent evidence indicates that glucocorticoids may help atten...

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Veröffentlicht in:Pharmacology, biochemistry and behavior biochemistry and behavior, 2015-06, Vol.133, p.43-50
Hauptverfasser: Xing, Xiaoli, Wang, Hongbo, Zhang, Lili, Bai, Yunjing, Liang, Jing, Liu, Zhengkui, Zheng, Xigeng
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container_title Pharmacology, biochemistry and behavior
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creator Xing, Xiaoli
Wang, Hongbo
Zhang, Lili
Bai, Yunjing
Liang, Jing
Liu, Zhengkui
Zheng, Xigeng
description The return of fear is an important issue in anxiety disorder research. Each time a fear memory is reactivated, it may further strengthen overactivation of the fear circuit, which may contribute to long-term maintenance of the fear memory. Recent evidence indicates that glucocorticoids may help attenuate pathological fear, but its role in the return of fear is unclear. In the present study, systemic corticosterone (CORT; 25mg/kg) administration 1h after fear conditioning did not impair the consolidation process but significantly suppressed the return of fear evoked by a subthreshold conditioning (SC) procedure and elevated platform (EP) stress. Compared with the SC-induced return of fear, acute stress-induced return was state-dependent. In addition, post-training CORT treatment increased the adrenocorticotropic response after EP stress, which indicates that the drug-induced suppression of the return of fear may possibly derive from its regulation effect of the hypothalamic–pituitary–adrenal axis reactivity to stress. These results suggest that post-training CORT administration may help inhibit the return of fear evoked by EP or SC stress. The possible mechanisms involved in the high-dose CORT-induced suppression of the SC- and EP-induced return of fear are discussed. •Both SC procedure and EP stress induced the return of fear.•CORT treatment suppressed the return of fear evoked by SC or EP stress.•Post-training CORT treatment increased ACTH response after EP stress.
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Each time a fear memory is reactivated, it may further strengthen overactivation of the fear circuit, which may contribute to long-term maintenance of the fear memory. Recent evidence indicates that glucocorticoids may help attenuate pathological fear, but its role in the return of fear is unclear. In the present study, systemic corticosterone (CORT; 25mg/kg) administration 1h after fear conditioning did not impair the consolidation process but significantly suppressed the return of fear evoked by a subthreshold conditioning (SC) procedure and elevated platform (EP) stress. Compared with the SC-induced return of fear, acute stress-induced return was state-dependent. In addition, post-training CORT treatment increased the adrenocorticotropic response after EP stress, which indicates that the drug-induced suppression of the return of fear may possibly derive from its regulation effect of the hypothalamic–pituitary–adrenal axis reactivity to stress. 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The possible mechanisms involved in the high-dose CORT-induced suppression of the SC- and EP-induced return of fear are discussed. •Both SC procedure and EP stress induced the return of fear.•CORT treatment suppressed the return of fear evoked by SC or EP stress.•Post-training CORT treatment increased ACTH response after EP stress.</description><subject>Adrenocorticotropic Hormone - blood</subject><subject>Animals</subject><subject>Conditioning, Classical - drug effects</subject><subject>Corticosterone</subject><subject>Corticosterone - blood</subject><subject>Corticosterone - pharmacology</subject><subject>Extinction</subject><subject>Extinction, Psychological - drug effects</subject><subject>Fear - drug effects</subject><subject>Fear conditioning</subject><subject>Fear return</subject><subject>Male</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Stress, Psychological - psychology</subject><subject>Subthreshold conditioning procedure</subject><issn>0091-3057</issn><issn>1873-5177</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUuO1DAQhi0EYpqBA7BBXrJJKMdx4ogVmuEljQQSsLb8qEy7ScfBdgb1jjsgLshJcNMDS1hZZX31Val-Qh4zqBmw7tmuXoypG2CiBl4D43fIhsmeV4L1_V2yARhYxUH0Z-RBSjsAaJuuv0_OGiGZhBY25Mf7kHKVo_azn6-pDTF7W74whhmpn7fe-Jxo3iKNmNc40zDSEXWkeBM-o6PmQJdJ5zHEPU05YkpUz45qmlaTt6XehskV7-x89uH3kCUGi26NRz_9sER9veLPb98v9dcJDzTqnB6Se6OeEj66fc_Jp1cvP168qa7evX578eKqslx2ubKyk0yg6_qWN67nFlsBYBCtGRtmtZBCas6g0e2AAxvADcgNajToxm40_Jw8PXnLSl9WTFntfbI4TXrGsCbFet7IppUD_B_tJAyi60AWlJ1QG0NKEUe1RL_X8aAYqGNwaqdKcOoYnAKuSnCl58mtfjV7dH87_iRVgOcnAMs9bjxGlazHuRzSR7RZueD_of8FtDit4Q</recordid><startdate>201506</startdate><enddate>201506</enddate><creator>Xing, Xiaoli</creator><creator>Wang, Hongbo</creator><creator>Zhang, Lili</creator><creator>Bai, Yunjing</creator><creator>Liang, Jing</creator><creator>Liu, Zhengkui</creator><creator>Zheng, Xigeng</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7QG</scope><scope>7TK</scope></search><sort><creationdate>201506</creationdate><title>Post-training corticosterone inhibits the return of fear evoked by platform stress and a subthreshold conditioning procedure in Sprague–Dawley rats</title><author>Xing, Xiaoli ; 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subjects Adrenocorticotropic Hormone - blood
Animals
Conditioning, Classical - drug effects
Corticosterone
Corticosterone - blood
Corticosterone - pharmacology
Extinction
Extinction, Psychological - drug effects
Fear - drug effects
Fear conditioning
Fear return
Male
Rats
Rats, Sprague-Dawley
Stress, Psychological - psychology
Subthreshold conditioning procedure
title Post-training corticosterone inhibits the return of fear evoked by platform stress and a subthreshold conditioning procedure in Sprague–Dawley rats
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