MuSK autoantibodies in myasthenia gravis detected by cell based assay — A multinational study
Abstract Seronegative myasthenia gravis (MG) presents a serious gap in MG diagnosis and understanding. We applied a cell based assay (CBA) for the detection of muscle specific kinase (MuSK) antibodies undetectable by radioimmunoassay. We tested 633 triple-seronegative MG patients' sera from 13...
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| Veröffentlicht in: | Journal of neuroimmunology 2015-07, Vol.284, p.10-17 |
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| creator | Tsonis, A.I Zisimopoulou, P Lazaridis, K Tzartos, J Matsigkou, E Zouvelou, V Mantegazza, R Antozzi, C Andreetta, F Evoli, A Deymeer, F Saruhan-Direskeneli, G Durmus, H Brenner, T Vaknin, A Berrih-Aknin, S Behin, A Sharshar, T De Baets, M Losen, M Martinez-Martinez, P Kleopa, K.A Zamba-Papanicolaou, E Kyriakides, T Kostera-Pruszczyk, A Szczudlik, P Szyluk, B Lavrnic, D Basta, I Peric, S Tallaksen, C Maniaol, A Casasnovas Pons, C Pitha, J Jakubíkova, M Hanisch, F Tzartos, S.J |
| description | Abstract Seronegative myasthenia gravis (MG) presents a serious gap in MG diagnosis and understanding. We applied a cell based assay (CBA) for the detection of muscle specific kinase (MuSK) antibodies undetectable by radioimmunoassay. We tested 633 triple-seronegative MG patients' sera from 13 countries, detecting 13% as positive. MuSK antibodies were found, at significantly lower frequencies, in 1.9% of healthy controls and 5.1% of other neuroimmune disease patients, including multiple sclerosis and neuromyelitis optica. The clinical data of the newly diagnosed MuSK-MG patients are presented. 27% of ocular seronegative patients were MuSK antibody positive. Moreover, 23% had thymic hyperplasia suggesting that thymic abnormalities are more common than believed. |
| doi_str_mv | 10.1016/j.jneuroim.2015.04.015 |
| format | Article |
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We applied a cell based assay (CBA) for the detection of muscle specific kinase (MuSK) antibodies undetectable by radioimmunoassay. We tested 633 triple-seronegative MG patients' sera from 13 countries, detecting 13% as positive. MuSK antibodies were found, at significantly lower frequencies, in 1.9% of healthy controls and 5.1% of other neuroimmune disease patients, including multiple sclerosis and neuromyelitis optica. The clinical data of the newly diagnosed MuSK-MG patients are presented. 27% of ocular seronegative patients were MuSK antibody positive. Moreover, 23% had thymic hyperplasia suggesting that thymic abnormalities are more common than believed.</description><identifier>ISSN: 0165-5728</identifier><identifier>EISSN: 1872-8421</identifier><identifier>DOI: 10.1016/j.jneuroim.2015.04.015</identifier><identifier>PMID: 26025053</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Adult ; Aged ; Allergy and Immunology ; Autoantibodies ; Autoantibodies - blood ; Cell based assay ; Diagnosis ; Female ; Flow Cytometry ; Humans ; International Cooperation ; LDL-Receptor Related Proteins - immunology ; Male ; Middle Aged ; MuSK ; Myasthenia gravis ; Myasthenia Gravis - blood ; Myasthenia Gravis - diagnosis ; Myasthenia Gravis - pathology ; Neurology ; Neuromyelitis Optica - diagnosis ; Radioimmunoassay ; Receptor Protein-Tyrosine Kinases - immunology ; Receptors, Cholinergic - immunology ; Thymus Gland - pathology ; Thymus Hyperplasia - diagnosis</subject><ispartof>Journal of neuroimmunology, 2015-07, Vol.284, p.10-17</ispartof><rights>Elsevier B.V.</rights><rights>2015 Elsevier B.V.</rights><rights>Copyright © 2015 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c504t-80eb3ffc60bbf8724042c1f5b3c60da07d0aad0371caa00ef536f7f5a2bf77a53</citedby><cites>FETCH-LOGICAL-c504t-80eb3ffc60bbf8724042c1f5b3c60da07d0aad0371caa00ef536f7f5a2bf77a53</cites><orcidid>0000-0001-8239-8830</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0165572815001113$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26025053$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tsonis, A.I</creatorcontrib><creatorcontrib>Zisimopoulou, P</creatorcontrib><creatorcontrib>Lazaridis, K</creatorcontrib><creatorcontrib>Tzartos, J</creatorcontrib><creatorcontrib>Matsigkou, E</creatorcontrib><creatorcontrib>Zouvelou, V</creatorcontrib><creatorcontrib>Mantegazza, R</creatorcontrib><creatorcontrib>Antozzi, C</creatorcontrib><creatorcontrib>Andreetta, F</creatorcontrib><creatorcontrib>Evoli, A</creatorcontrib><creatorcontrib>Deymeer, F</creatorcontrib><creatorcontrib>Saruhan-Direskeneli, G</creatorcontrib><creatorcontrib>Durmus, H</creatorcontrib><creatorcontrib>Brenner, T</creatorcontrib><creatorcontrib>Vaknin, A</creatorcontrib><creatorcontrib>Berrih-Aknin, S</creatorcontrib><creatorcontrib>Behin, A</creatorcontrib><creatorcontrib>Sharshar, T</creatorcontrib><creatorcontrib>De Baets, M</creatorcontrib><creatorcontrib>Losen, M</creatorcontrib><creatorcontrib>Martinez-Martinez, P</creatorcontrib><creatorcontrib>Kleopa, K.A</creatorcontrib><creatorcontrib>Zamba-Papanicolaou, E</creatorcontrib><creatorcontrib>Kyriakides, T</creatorcontrib><creatorcontrib>Kostera-Pruszczyk, A</creatorcontrib><creatorcontrib>Szczudlik, P</creatorcontrib><creatorcontrib>Szyluk, B</creatorcontrib><creatorcontrib>Lavrnic, D</creatorcontrib><creatorcontrib>Basta, I</creatorcontrib><creatorcontrib>Peric, S</creatorcontrib><creatorcontrib>Tallaksen, C</creatorcontrib><creatorcontrib>Maniaol, A</creatorcontrib><creatorcontrib>Casasnovas Pons, C</creatorcontrib><creatorcontrib>Pitha, J</creatorcontrib><creatorcontrib>Jakubíkova, M</creatorcontrib><creatorcontrib>Hanisch, F</creatorcontrib><creatorcontrib>Tzartos, S.J</creatorcontrib><title>MuSK autoantibodies in myasthenia gravis detected by cell based assay — A multinational study</title><title>Journal of neuroimmunology</title><addtitle>J Neuroimmunol</addtitle><description>Abstract Seronegative myasthenia gravis (MG) presents a serious gap in MG diagnosis and understanding. We applied a cell based assay (CBA) for the detection of muscle specific kinase (MuSK) antibodies undetectable by radioimmunoassay. We tested 633 triple-seronegative MG patients' sera from 13 countries, detecting 13% as positive. MuSK antibodies were found, at significantly lower frequencies, in 1.9% of healthy controls and 5.1% of other neuroimmune disease patients, including multiple sclerosis and neuromyelitis optica. The clinical data of the newly diagnosed MuSK-MG patients are presented. 27% of ocular seronegative patients were MuSK antibody positive. Moreover, 23% had thymic hyperplasia suggesting that thymic abnormalities are more common than believed.</description><subject>Adult</subject><subject>Aged</subject><subject>Allergy and Immunology</subject><subject>Autoantibodies</subject><subject>Autoantibodies - blood</subject><subject>Cell based assay</subject><subject>Diagnosis</subject><subject>Female</subject><subject>Flow Cytometry</subject><subject>Humans</subject><subject>International Cooperation</subject><subject>LDL-Receptor Related Proteins - immunology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>MuSK</subject><subject>Myasthenia gravis</subject><subject>Myasthenia Gravis - blood</subject><subject>Myasthenia Gravis - diagnosis</subject><subject>Myasthenia Gravis - pathology</subject><subject>Neurology</subject><subject>Neuromyelitis Optica - diagnosis</subject><subject>Radioimmunoassay</subject><subject>Receptor Protein-Tyrosine Kinases - immunology</subject><subject>Receptors, Cholinergic - immunology</subject><subject>Thymus Gland - 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| subjects | Adult Aged Allergy and Immunology Autoantibodies Autoantibodies - blood Cell based assay Diagnosis Female Flow Cytometry Humans International Cooperation LDL-Receptor Related Proteins - immunology Male Middle Aged MuSK Myasthenia gravis Myasthenia Gravis - blood Myasthenia Gravis - diagnosis Myasthenia Gravis - pathology Neurology Neuromyelitis Optica - diagnosis Radioimmunoassay Receptor Protein-Tyrosine Kinases - immunology Receptors, Cholinergic - immunology Thymus Gland - pathology Thymus Hyperplasia - diagnosis |
| title | MuSK autoantibodies in myasthenia gravis detected by cell based assay — A multinational study |
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