Only humans have human placentas: molecular differences between mice and humans
Highlights • The mouse model does not reflect human placentation properly. • The structure of the human placenta is different from that of most animal species. • The human placenta has numerous primate- and human-specific genetic features. • MicroRNAs are often species- or clade-specific. • Conserve...
Gespeichert in:
| Veröffentlicht in: | Journal of reproductive immunology 2015-04, Vol.108, p.65-71 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 71 |
|---|---|
| container_issue | |
| container_start_page | 65 |
| container_title | Journal of reproductive immunology |
| container_volume | 108 |
| creator | Schmidt, André Morales-Prieto, Diana M Pastuschek, Jana Fröhlich, Karolin Markert, Udo R |
| description | Highlights • The mouse model does not reflect human placentation properly. • The structure of the human placenta is different from that of most animal species. • The human placenta has numerous primate- and human-specific genetic features. • MicroRNAs are often species- or clade-specific. • Conserved microRNAs show species-specific target repertoires. |
| doi_str_mv | 10.1016/j.jri.2015.03.001 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1732823100</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>1_s2_0_S0165037815000364</els_id><sourcerecordid>1672090605</sourcerecordid><originalsourceid>FETCH-LOGICAL-c577t-4b94091920d132a219818422feed93b588ee5e3fc94cac3ae5e015335f924c813</originalsourceid><addsrcrecordid>eNqFkU2r1DAUhoMo3vHqD3AjXbppPSdp2lRBkItfcGEW6jpk0lNuapqOSXtl_r0pM7pwoask8LwvOc9h7DlChYDNq7Eao6s4oKxAVAD4gO1QtbxsGxAP2S4zsgTRqiv2JKUxAy10-JhdcamwrRu5Y_t98Kfibp1MSMWduafzvTh6YyksJr0uptmTXb2JRe-GgSIFS6k40PKTKBSTs1SY0F86nrJHg_GJnl3Oa_btw_uvN5_K2_3Hzzfvbksr23Yp60NX5690HHoU3HDsFKqa84Go78RBKkUkSQy2q62xwuRHnlIIOXS8tgrFNXt57j3G-cdKadGTS5a8N4HmNWlsBVdcIMD_0abl0EEDMqN4Rm2cU4o06GN0k4knjaA35XrUWbnelGsQOhvNmReX-vUwUf8n8dtxBt6cAco-7h1FnazbJPYukl10P7t_1r_9K229C84a_51OlMZ5jSGL1qgT16C_bDvfVo4S8uxNLX4Bahek4Q</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1672090605</pqid></control><display><type>article</type><title>Only humans have human placentas: molecular differences between mice and humans</title><source>MEDLINE</source><source>Access via ScienceDirect (Elsevier)</source><creator>Schmidt, André ; Morales-Prieto, Diana M ; Pastuschek, Jana ; Fröhlich, Karolin ; Markert, Udo R</creator><creatorcontrib>Schmidt, André ; Morales-Prieto, Diana M ; Pastuschek, Jana ; Fröhlich, Karolin ; Markert, Udo R</creatorcontrib><description>Highlights • The mouse model does not reflect human placentation properly. • The structure of the human placenta is different from that of most animal species. • The human placenta has numerous primate- and human-specific genetic features. • MicroRNAs are often species- or clade-specific. • Conserved microRNAs show species-specific target repertoires.</description><identifier>ISSN: 0165-0378</identifier><identifier>EISSN: 1872-7603</identifier><identifier>DOI: 10.1016/j.jri.2015.03.001</identifier><identifier>PMID: 25817465</identifier><language>eng</language><publisher>Ireland: Elsevier Ireland Ltd</publisher><subject>Animals ; Chorionic Gonadotropin - metabolism ; Female ; Human chorionic gonadotropin ; Humans ; Mice ; microRNA ; Models, Animal ; Mouse model ; Obstetrics and Gynecology ; Placenta ; Placenta - physiology ; Pregnancy ; Primates ; Species Specificity ; Trophoblast</subject><ispartof>Journal of reproductive immunology, 2015-04, Vol.108, p.65-71</ispartof><rights>Elsevier Ireland Ltd</rights><rights>2015 Elsevier Ireland Ltd</rights><rights>Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c577t-4b94091920d132a219818422feed93b588ee5e3fc94cac3ae5e015335f924c813</citedby><cites>FETCH-LOGICAL-c577t-4b94091920d132a219818422feed93b588ee5e3fc94cac3ae5e015335f924c813</cites><orcidid>0000-0001-5299-595X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jri.2015.03.001$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,781,785,3551,27929,27930,46000</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25817465$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Schmidt, André</creatorcontrib><creatorcontrib>Morales-Prieto, Diana M</creatorcontrib><creatorcontrib>Pastuschek, Jana</creatorcontrib><creatorcontrib>Fröhlich, Karolin</creatorcontrib><creatorcontrib>Markert, Udo R</creatorcontrib><title>Only humans have human placentas: molecular differences between mice and humans</title><title>Journal of reproductive immunology</title><addtitle>J Reprod Immunol</addtitle><description>Highlights • The mouse model does not reflect human placentation properly. • The structure of the human placenta is different from that of most animal species. • The human placenta has numerous primate- and human-specific genetic features. • MicroRNAs are often species- or clade-specific. • Conserved microRNAs show species-specific target repertoires.</description><subject>Animals</subject><subject>Chorionic Gonadotropin - metabolism</subject><subject>Female</subject><subject>Human chorionic gonadotropin</subject><subject>Humans</subject><subject>Mice</subject><subject>microRNA</subject><subject>Models, Animal</subject><subject>Mouse model</subject><subject>Obstetrics and Gynecology</subject><subject>Placenta</subject><subject>Placenta - physiology</subject><subject>Pregnancy</subject><subject>Primates</subject><subject>Species Specificity</subject><subject>Trophoblast</subject><issn>0165-0378</issn><issn>1872-7603</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU2r1DAUhoMo3vHqD3AjXbppPSdp2lRBkItfcGEW6jpk0lNuapqOSXtl_r0pM7pwoask8LwvOc9h7DlChYDNq7Eao6s4oKxAVAD4gO1QtbxsGxAP2S4zsgTRqiv2JKUxAy10-JhdcamwrRu5Y_t98Kfibp1MSMWduafzvTh6YyksJr0uptmTXb2JRe-GgSIFS6k40PKTKBSTs1SY0F86nrJHg_GJnl3Oa_btw_uvN5_K2_3Hzzfvbksr23Yp60NX5690HHoU3HDsFKqa84Go78RBKkUkSQy2q62xwuRHnlIIOXS8tgrFNXt57j3G-cdKadGTS5a8N4HmNWlsBVdcIMD_0abl0EEDMqN4Rm2cU4o06GN0k4knjaA35XrUWbnelGsQOhvNmReX-vUwUf8n8dtxBt6cAco-7h1FnazbJPYukl10P7t_1r_9K229C84a_51OlMZ5jSGL1qgT16C_bDvfVo4S8uxNLX4Bahek4Q</recordid><startdate>20150401</startdate><enddate>20150401</enddate><creator>Schmidt, André</creator><creator>Morales-Prieto, Diana M</creator><creator>Pastuschek, Jana</creator><creator>Fröhlich, Karolin</creator><creator>Markert, Udo R</creator><general>Elsevier Ireland Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7T5</scope><scope>H94</scope><orcidid>https://orcid.org/0000-0001-5299-595X</orcidid></search><sort><creationdate>20150401</creationdate><title>Only humans have human placentas: molecular differences between mice and humans</title><author>Schmidt, André ; Morales-Prieto, Diana M ; Pastuschek, Jana ; Fröhlich, Karolin ; Markert, Udo R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c577t-4b94091920d132a219818422feed93b588ee5e3fc94cac3ae5e015335f924c813</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Animals</topic><topic>Chorionic Gonadotropin - metabolism</topic><topic>Female</topic><topic>Human chorionic gonadotropin</topic><topic>Humans</topic><topic>Mice</topic><topic>microRNA</topic><topic>Models, Animal</topic><topic>Mouse model</topic><topic>Obstetrics and Gynecology</topic><topic>Placenta</topic><topic>Placenta - physiology</topic><topic>Pregnancy</topic><topic>Primates</topic><topic>Species Specificity</topic><topic>Trophoblast</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Schmidt, André</creatorcontrib><creatorcontrib>Morales-Prieto, Diana M</creatorcontrib><creatorcontrib>Pastuschek, Jana</creatorcontrib><creatorcontrib>Fröhlich, Karolin</creatorcontrib><creatorcontrib>Markert, Udo R</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>Journal of reproductive immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Schmidt, André</au><au>Morales-Prieto, Diana M</au><au>Pastuschek, Jana</au><au>Fröhlich, Karolin</au><au>Markert, Udo R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Only humans have human placentas: molecular differences between mice and humans</atitle><jtitle>Journal of reproductive immunology</jtitle><addtitle>J Reprod Immunol</addtitle><date>2015-04-01</date><risdate>2015</risdate><volume>108</volume><spage>65</spage><epage>71</epage><pages>65-71</pages><issn>0165-0378</issn><eissn>1872-7603</eissn><abstract>Highlights • The mouse model does not reflect human placentation properly. • The structure of the human placenta is different from that of most animal species. • The human placenta has numerous primate- and human-specific genetic features. • MicroRNAs are often species- or clade-specific. • Conserved microRNAs show species-specific target repertoires.</abstract><cop>Ireland</cop><pub>Elsevier Ireland Ltd</pub><pmid>25817465</pmid><doi>10.1016/j.jri.2015.03.001</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0001-5299-595X</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0165-0378 |
| ispartof | Journal of reproductive immunology, 2015-04, Vol.108, p.65-71 |
| issn | 0165-0378 1872-7603 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1732823100 |
| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Animals Chorionic Gonadotropin - metabolism Female Human chorionic gonadotropin Humans Mice microRNA Models, Animal Mouse model Obstetrics and Gynecology Placenta Placenta - physiology Pregnancy Primates Species Specificity Trophoblast |
| title | Only humans have human placentas: molecular differences between mice and humans |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-13T03%3A34%3A40IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Only%20humans%20have%20human%20placentas:%20molecular%20differences%20between%20mice%20and%20humans&rft.jtitle=Journal%20of%20reproductive%20immunology&rft.au=Schmidt,%20Andr%C3%A9&rft.date=2015-04-01&rft.volume=108&rft.spage=65&rft.epage=71&rft.pages=65-71&rft.issn=0165-0378&rft.eissn=1872-7603&rft_id=info:doi/10.1016/j.jri.2015.03.001&rft_dat=%3Cproquest_cross%3E1672090605%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1672090605&rft_id=info:pmid/25817465&rft_els_id=1_s2_0_S0165037815000364&rfr_iscdi=true |