Nucleotides maintain the activity of Cav1.2 channels in guinea-pig ventricular myocytes

The activity of Cav1.2 Ca2+ channels is maintained in the presence of calmodulin and ATP, even in cell-free patches, and thus a channel ATP-binding site has been suggested. In this study, we examined whether other nucleotides, such as GTP, UTP, CTP, ADP and AMP, could be substituted for ATP in guine...

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Veröffentlicht in:	Biochemical and biophysical research communications 2015-05, Vol.460 (3), p.813-818
Hauptverfasser:	Liu, Shu-yuan, Xu, Jian-jun, Minobe, Etsuko, Gao, Qing-hua, Feng, Rui, Zhao, Mei-mi, Guo, Feng, Yang, Lei, Hao, Li-ying, Kameyama, Masaki
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals ATP Binding site Ca2+ channel Calcium Channels - metabolism Cav1.2 Guinea Pigs Heart Ventricles - cytology Heart Ventricles - metabolism Muscle, Smooth, Vascular - cytology Muscle, Smooth, Vascular - metabolism Nucleotide Nucleotides - physiology
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