Promising MS2 mediated virus-like particle vaccine against foot-and-mouth disease

•We generated a recombinant VLP vaccine against FMDV.•VLP can produce high neutralizing antibody against FMDV.•The enhanced protection effect was demonstrated in pigs, mice and guinea pigs. Foot-and-mouth disease (FMD) has caused severe economic losses to millions of farmers worldwide. In this work,...

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Veröffentlicht in:	Antiviral research 2015-05, Vol.117, p.39-43
Hauptverfasser:	Dong, Yan-mei, Zhang, Guo-guang, Huang, Xiao-jun, Chen, Liang, Chen, Hao-tai
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Neutralizing - biosynthesis Antibodies, Viral - biosynthesis Antibodies, Viral - immunology Capsid Proteins - genetics Capsid Proteins - immunology Enzyme-Linked Immunosorbent Assay Epitopes Foot-and-mouth disease (FMD) Foot-and-Mouth Disease - immunology Foot-and-Mouth Disease - prevention & control Foot-and-mouth disease virus Foot-and-Mouth Disease Virus - genetics Foot-and-Mouth Disease Virus - immunology Freund's Adjuvant Guinea Pigs Immunity Levivirus - genetics Mice Neutralization Tests Swine Vaccine Vaccines, Virus-Like Particle - administration & dosage Vaccines, Virus-Like Particle - immunology Viral Vaccines - administration & dosage Viral Vaccines - immunology Virus-like particles (VLP)
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