Paediatric bone and joint infections are more common in boys and toddlers: a national epidemiology study
Aim Little is known about bone and joint infections (BJIs) in children, despite the risk of growth disturbance. This study examined BJIs epidemiology using the French National Hospital Discharge Database (HD). Methods Any child
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| Veröffentlicht in: | Acta Paediatrica 2013-03, Vol.102 (3), p.e120-e125 |
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| container_title | Acta Paediatrica |
| container_volume | 102 |
| creator | Grammatico-Guillon, L Maakaroun Vermesse, Z Baron, S Gettner, S Rusch, E Bernard, L |
| description | Aim
Little is known about bone and joint infections (BJIs) in children, despite the risk of growth disturbance. This study examined BJIs epidemiology using the French National Hospital Discharge Database (HD).
Methods
Any child |
| doi_str_mv | 10.1111/apa.12115 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1732820169</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1732820169</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4245-75764302c19eabc03a0a079f78f1d95574e37ee7e71f95a560d9a03511ba2f7c3</originalsourceid><addsrcrecordid>eNqF0cFu1DAQBmALUdGlcOAFkCUucEjrseM44basoEWqSg-gPVqzyQS8JPHWTgR5e9zdtgekqj7YB3_zS6OfsTcgTiGdM9zhKUgA_YwtoNCQSSnNc7YQpVCZllods5cxboWQqsqLF-xYKil0mcOC_bpGahyOwdV84wfiODR8690wcje0VI_OD5FjIN77dNW-7_2QvhKe4x6Pvmk6CvEjRz7grceO08411Dvf-Z8zj-PUzK_YUYtdpNd37wn78eXz99VFdvnt_OtqeZnVucx1ZrQpciVkDRXhphYKBQpTtaZsoam0NjkpQ2TIQFtp1IVoKhRKA2xQtqZWJ-z9IXcX_M1EcbS9izV1HQ7kp2jBKFlKAUX1NJWlFqWCChJ99x_d-imkTfcqh7IAJZL6cFB18DEGau0uuB7DbEHY26Zsasrum0r27V3itOmpeZD31SRwdgB_XEfz40l2eb28j8wOEy6O9PdhAsNvWxhltF1fnduL9Up-WlVra9Q_F5CqXg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1284186130</pqid></control><display><type>article</type><title>Paediatric bone and joint infections are more common in boys and toddlers: a national epidemiology study</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><source>Alma/SFX Local Collection</source><creator>Grammatico-Guillon, L ; Maakaroun Vermesse, Z ; Baron, S ; Gettner, S ; Rusch, E ; Bernard, L</creator><creatorcontrib>Grammatico-Guillon, L ; Maakaroun Vermesse, Z ; Baron, S ; Gettner, S ; Rusch, E ; Bernard, L</creatorcontrib><description>Aim
Little is known about bone and joint infections (BJIs) in children, despite the risk of growth disturbance. This study examined BJIs epidemiology using the French National Hospital Discharge Database (HD).
Methods
Any child <15 years hospitalized with an HD diagnosis of BJI, alone or in combination with sepsis or orthopaedic procedure, was included. The majority of BJIs (96%) were haematogenic infections. We conducted descriptive analyses to evaluate epidemiological and economic outcomes of paediatric haematogenic BJIs.
Results
There were 2592 paediatric patients with 2911 BJI hospitalizations and an overall incidence of 22 per 100 000. BJIs occurred more frequently in boys than girls (24 vs 19 per 100 000) and in toddlers. Septic arthritis (52%) and osteomyelitis (44%) were the most frequent infections, 16.6% of patients had a micro‐organism coded (61% were Staphylococci) and 13% of had comorbidities. The mean hospital stay was 8.6 days, costing approximately €5200 per BJI stay.
Conclusion
This national study of paediatric BJIs in France showed a higher prevalence in toddlers and boys and demonstrated that the HD database can be used to study BJIs. However, the number of BJI cases was maybe overestimated by coding reactive arthritis as septic arthritis in the absence of bacterial evidence.</description><identifier>ISSN: 0803-5253</identifier><identifier>EISSN: 1651-2227</identifier><identifier>DOI: 10.1111/apa.12115</identifier><identifier>PMID: 23205841</identifier><language>eng</language><publisher>Norway: Blackwell Publishing Ltd</publisher><subject>Adolescent ; Bone Diseases, Infectious - epidemiology ; Bone Diseases, Infectious - microbiology ; Bone Diseases, Infectious - therapy ; Child ; Child, Preschool ; Cost of Illness ; Databases, Factual ; Epidemiology ; Female ; France - epidemiology ; Hospital discharge database ; Hospitalization - statistics & numerical data ; Humans ; Incidence ; Infant ; Joint Diseases - epidemiology ; Joint Diseases - microbiology ; Joint Diseases - therapy ; Male ; Osteomyelitis ; Paediatric ; Retrospective Studies ; Risk Factors ; Septic arthritis</subject><ispartof>Acta Paediatrica, 2013-03, Vol.102 (3), p.e120-e125</ispartof><rights>2012 The Author(s)/Acta Pædiatrica ©2012 Foundation Acta Pædiatrica</rights><rights>2012 The Author(s)/Acta Paediatrica ©2012 Foundation Acta Paediatrica.</rights><rights>Copyright © 2013 Foundation Acta Pædiatrica</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4245-75764302c19eabc03a0a079f78f1d95574e37ee7e71f95a560d9a03511ba2f7c3</citedby><cites>FETCH-LOGICAL-c4245-75764302c19eabc03a0a079f78f1d95574e37ee7e71f95a560d9a03511ba2f7c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fapa.12115$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fapa.12115$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23205841$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Grammatico-Guillon, L</creatorcontrib><creatorcontrib>Maakaroun Vermesse, Z</creatorcontrib><creatorcontrib>Baron, S</creatorcontrib><creatorcontrib>Gettner, S</creatorcontrib><creatorcontrib>Rusch, E</creatorcontrib><creatorcontrib>Bernard, L</creatorcontrib><title>Paediatric bone and joint infections are more common in boys and toddlers: a national epidemiology study</title><title>Acta Paediatrica</title><addtitle>Acta Paediatr</addtitle><description>Aim
Little is known about bone and joint infections (BJIs) in children, despite the risk of growth disturbance. This study examined BJIs epidemiology using the French National Hospital Discharge Database (HD).
Methods
Any child <15 years hospitalized with an HD diagnosis of BJI, alone or in combination with sepsis or orthopaedic procedure, was included. The majority of BJIs (96%) were haematogenic infections. We conducted descriptive analyses to evaluate epidemiological and economic outcomes of paediatric haematogenic BJIs.
Results
There were 2592 paediatric patients with 2911 BJI hospitalizations and an overall incidence of 22 per 100 000. BJIs occurred more frequently in boys than girls (24 vs 19 per 100 000) and in toddlers. Septic arthritis (52%) and osteomyelitis (44%) were the most frequent infections, 16.6% of patients had a micro‐organism coded (61% were Staphylococci) and 13% of had comorbidities. The mean hospital stay was 8.6 days, costing approximately €5200 per BJI stay.
Conclusion
This national study of paediatric BJIs in France showed a higher prevalence in toddlers and boys and demonstrated that the HD database can be used to study BJIs. However, the number of BJI cases was maybe overestimated by coding reactive arthritis as septic arthritis in the absence of bacterial evidence.</description><subject>Adolescent</subject><subject>Bone Diseases, Infectious - epidemiology</subject><subject>Bone Diseases, Infectious - microbiology</subject><subject>Bone Diseases, Infectious - therapy</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Cost of Illness</subject><subject>Databases, Factual</subject><subject>Epidemiology</subject><subject>Female</subject><subject>France - epidemiology</subject><subject>Hospital discharge database</subject><subject>Hospitalization - statistics & numerical data</subject><subject>Humans</subject><subject>Incidence</subject><subject>Infant</subject><subject>Joint Diseases - epidemiology</subject><subject>Joint Diseases - microbiology</subject><subject>Joint Diseases - therapy</subject><subject>Male</subject><subject>Osteomyelitis</subject><subject>Paediatric</subject><subject>Retrospective Studies</subject><subject>Risk Factors</subject><subject>Septic arthritis</subject><issn>0803-5253</issn><issn>1651-2227</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0cFu1DAQBmALUdGlcOAFkCUucEjrseM44basoEWqSg-gPVqzyQS8JPHWTgR5e9zdtgekqj7YB3_zS6OfsTcgTiGdM9zhKUgA_YwtoNCQSSnNc7YQpVCZllods5cxboWQqsqLF-xYKil0mcOC_bpGahyOwdV84wfiODR8690wcje0VI_OD5FjIN77dNW-7_2QvhKe4x6Pvmk6CvEjRz7grceO08411Dvf-Z8zj-PUzK_YUYtdpNd37wn78eXz99VFdvnt_OtqeZnVucx1ZrQpciVkDRXhphYKBQpTtaZsoam0NjkpQ2TIQFtp1IVoKhRKA2xQtqZWJ-z9IXcX_M1EcbS9izV1HQ7kp2jBKFlKAUX1NJWlFqWCChJ99x_d-imkTfcqh7IAJZL6cFB18DEGau0uuB7DbEHY26Zsasrum0r27V3itOmpeZD31SRwdgB_XEfz40l2eb28j8wOEy6O9PdhAsNvWxhltF1fnduL9Up-WlVra9Q_F5CqXg</recordid><startdate>201303</startdate><enddate>201303</enddate><creator>Grammatico-Guillon, L</creator><creator>Maakaroun Vermesse, Z</creator><creator>Baron, S</creator><creator>Gettner, S</creator><creator>Rusch, E</creator><creator>Bernard, L</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TK</scope><scope>7TM</scope><scope>7TS</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>7X8</scope><scope>7QP</scope></search><sort><creationdate>201303</creationdate><title>Paediatric bone and joint infections are more common in boys and toddlers: a national epidemiology study</title><author>Grammatico-Guillon, L ; Maakaroun Vermesse, Z ; Baron, S ; Gettner, S ; Rusch, E ; Bernard, L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4245-75764302c19eabc03a0a079f78f1d95574e37ee7e71f95a560d9a03511ba2f7c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adolescent</topic><topic>Bone Diseases, Infectious - epidemiology</topic><topic>Bone Diseases, Infectious - microbiology</topic><topic>Bone Diseases, Infectious - therapy</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Cost of Illness</topic><topic>Databases, Factual</topic><topic>Epidemiology</topic><topic>Female</topic><topic>France - epidemiology</topic><topic>Hospital discharge database</topic><topic>Hospitalization - statistics & numerical data</topic><topic>Humans</topic><topic>Incidence</topic><topic>Infant</topic><topic>Joint Diseases - epidemiology</topic><topic>Joint Diseases - microbiology</topic><topic>Joint Diseases - therapy</topic><topic>Male</topic><topic>Osteomyelitis</topic><topic>Paediatric</topic><topic>Retrospective Studies</topic><topic>Risk Factors</topic><topic>Septic arthritis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Grammatico-Guillon, L</creatorcontrib><creatorcontrib>Maakaroun Vermesse, Z</creatorcontrib><creatorcontrib>Baron, S</creatorcontrib><creatorcontrib>Gettner, S</creatorcontrib><creatorcontrib>Rusch, E</creatorcontrib><creatorcontrib>Bernard, L</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Physical Education Index</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>MEDLINE - Academic</collection><collection>Calcium & Calcified Tissue Abstracts</collection><jtitle>Acta Paediatrica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Grammatico-Guillon, L</au><au>Maakaroun Vermesse, Z</au><au>Baron, S</au><au>Gettner, S</au><au>Rusch, E</au><au>Bernard, L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Paediatric bone and joint infections are more common in boys and toddlers: a national epidemiology study</atitle><jtitle>Acta Paediatrica</jtitle><addtitle>Acta Paediatr</addtitle><date>2013-03</date><risdate>2013</risdate><volume>102</volume><issue>3</issue><spage>e120</spage><epage>e125</epage><pages>e120-e125</pages><issn>0803-5253</issn><eissn>1651-2227</eissn><abstract>Aim
Little is known about bone and joint infections (BJIs) in children, despite the risk of growth disturbance. This study examined BJIs epidemiology using the French National Hospital Discharge Database (HD).
Methods
Any child <15 years hospitalized with an HD diagnosis of BJI, alone or in combination with sepsis or orthopaedic procedure, was included. The majority of BJIs (96%) were haematogenic infections. We conducted descriptive analyses to evaluate epidemiological and economic outcomes of paediatric haematogenic BJIs.
Results
There were 2592 paediatric patients with 2911 BJI hospitalizations and an overall incidence of 22 per 100 000. BJIs occurred more frequently in boys than girls (24 vs 19 per 100 000) and in toddlers. Septic arthritis (52%) and osteomyelitis (44%) were the most frequent infections, 16.6% of patients had a micro‐organism coded (61% were Staphylococci) and 13% of had comorbidities. The mean hospital stay was 8.6 days, costing approximately €5200 per BJI stay.
Conclusion
This national study of paediatric BJIs in France showed a higher prevalence in toddlers and boys and demonstrated that the HD database can be used to study BJIs. However, the number of BJI cases was maybe overestimated by coding reactive arthritis as septic arthritis in the absence of bacterial evidence.</abstract><cop>Norway</cop><pub>Blackwell Publishing Ltd</pub><pmid>23205841</pmid><doi>10.1111/apa.12115</doi><tpages>6</tpages></addata></record> |
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| subjects | Adolescent Bone Diseases, Infectious - epidemiology Bone Diseases, Infectious - microbiology Bone Diseases, Infectious - therapy Child Child, Preschool Cost of Illness Databases, Factual Epidemiology Female France - epidemiology Hospital discharge database Hospitalization - statistics & numerical data Humans Incidence Infant Joint Diseases - epidemiology Joint Diseases - microbiology Joint Diseases - therapy Male Osteomyelitis Paediatric Retrospective Studies Risk Factors Septic arthritis |
| title | Paediatric bone and joint infections are more common in boys and toddlers: a national epidemiology study |
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