Transcellular spreading of huntingtin aggregates in the Drosophila brain

A key feature of many neurodegenerative diseases is the accumulation and subsequent aggregation of misfolded proteins. Recent studies have highlighted the transcellular propagation of protein aggregates in several major neurodegenerative diseases, although the precise mechanisms underlying this spre...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2015-09, Vol.112 (39), p.E5427-E5433
Hauptverfasser:	Babcock, Daniel T, Ganetzky, Barry
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological Sciences Brain - physiology Drosophila Drosophila - physiology Huntingtin Protein Huntingtons disease Immunohistochemistry Insects Microscopy, Confocal Microtubule-Associated Proteins - genetics Microtubule-Associated Proteins - physiology Neurodegenerative Diseases - physiopathology Neurology Neurons Pathology Peptides - genetics PNAS Plus Protein Aggregates - physiology Protein expression Protein folding Transcytosis - physiology Trinucleotide Repeat Expansion - genetics
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