Cytotoxic Impact of Costunolide Isolated from Costus speciosus on Breast Cancer via Differential Regulation of Cell Cycle-An In-vitro and In-silico Approach

Costunolide, a sesquiterpene lactone, is a biologically active molecule found in most of the medicinally valuable plants. The present study aims to evaluate the anticancer property of costunolide isolated from Costus speciosus against breast cancer cell lines (MCF‐7 and MDA‐MB‐231). Costunolide effe...

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Veröffentlicht in:	Phytotherapy research 2015-10, Vol.29 (10), p.1532-1539
Hauptverfasser:	Roy, Anita, Manikkam, Rajalakshmi
Format:	Artikel
Sprache:	eng
Schlagworte:	anticancer apoptosis Apoptosis - drug effects Breast Breast Neoplasms - drug therapy Breast Neoplasms - metabolism Caspase 3 - metabolism Caspase 9 cell cycle Cell Cycle - drug effects Cell Cycle Checkpoints - drug effects Cell Division Cell Line, Tumor Cell Proliferation - drug effects Computer Simulation Costus docking Female G2 Phase - drug effects Humans Nitric Oxide Synthase - antagonists & inhibitors Phytotherapy Sesquiterpenes - pharmacology
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