Minocycline enhances hippocampal memory, neuroplasticity and synapse-associated proteins in aged C57 BL/6 mice

•Minocycline ameliorates cognitive deficit, enhances synaptic plasticity in aged mice.•Minocycline activates BDNF-ERKs signaling in aged mice.•Minocycline increases immediate early genes or synaptic proteins in aged mice.•Minocycline mediates improvement in cognition during aging. Previous studies h...

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Veröffentlicht in:	Neurobiology of learning and memory 2015-05, Vol.121, p.20-29
Hauptverfasser:	Jiang, Ying, Liu, Yingying, Zhu, Cansheng, Ma, Xiaomeng, Ma, Lili, Zhou, Linli, Huang, Qiling, Cen, Lei, Pi, Rongbiao, Chen, Xiaohong
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging Animal cognition Animals Avoidance Learning - drug effects Avoidance Learning - physiology Brain Brain-derived neurotrophic factor Brain-Derived Neurotrophic Factor - metabolism Cognitive deficit Cytoskeletal Proteins - metabolism Dendritic Spines - drug effects Early Growth Response Protein 1 - metabolism Gene expression Hippocampus - drug effects Hippocampus - physiology Hippocampus - ultrastructure Indans - administration & dosage Long-Term Potentiation - drug effects Male MAP Kinase Signaling System - drug effects Maze Learning - drug effects Maze Learning - physiology Memory Memory - drug effects Memory - physiology Mice Mice, Inbred C57BL Minocycline Minocycline - administration & dosage Nerve Tissue Proteins - metabolism Neurons Neurons - physiology Neurons - ultrastructure Nootropic Agents - administration & dosage Piperidines - administration & dosage Proteins Rodents Synapses - metabolism Synaptic plasticity
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