Mitomycin C modulates the circadian oscillation of clock gene period 2 expression through attenuating the glucocorticoid signaling in mouse fibroblasts

Clock gene regulates the circadian rhythm of various physiological functions. The expression of clock gene has been shown to be attenuated by certain drugs, resulting in a rhythm disorder. Mitomycin C (MMC) is often used in combination with ophthalmic surgery, especially in trabeculectomy, a glaucom...

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Veröffentlicht in:	Biochemical and biophysical research communications 2015-11, Vol.467 (1), p.157-163
Hauptverfasser:	Kusunose, Naoki, Matsunaga, Naoya, Kimoto, Kenichi, Akamine, Takahiro, Hamamura, Kengo, Koyanagi, Satoru, Ohdo, Shigehiro, Kubota, Toshiaki
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals ARNTL Transcription Factors - genetics Chronobiology Disorders - etiology Chronobiology Disorders - genetics Chronobiology Disorders - metabolism Circadian Clocks - drug effects Circadian Clocks - genetics Circadian Clocks - physiology Circadian rhythm Circadian Rhythm - drug effects Circadian Rhythm - genetics Clock gene CLOCK Proteins - genetics Dexamethasone - pharmacology DNA-Binding Proteins - genetics Eye - metabolism Gene Expression - drug effects Glucocorticoid receptor Mice Mice, Transgenic Mitomycin - adverse effects Mitomycin - pharmacology Mitomycin C NIH 3T3 Cells Nuclear Receptor Subfamily 1, Group D, Member 1 - genetics Period Circadian Proteins - genetics Receptors, Glucocorticoid - genetics RNA, Messenger - genetics RNA, Messenger - metabolism Signal Transduction - drug effects Trabeculectomy Trabeculectomy - adverse effects Transcription Factors - genetics
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