A Novel Missense Mutation of the MEN1 Gene in a Patient with Multiple Endocrine Neoplasia Type 1 with Glucagonoma and Obesity

A 35-year-old obese diabetic man presented with recurrent primary hyperparathyroidism during a three-year outpatient follow-up. He was clinically diagnosed with multiple endocrine neoplasia type 1 (MEN1) due to the presence of a pituitary adenoma and multiple glucagonomas. The glucagonomas may have...

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Veröffentlicht in:	Internal Medicine 2015, Vol.54(19), pp.2475-2481
Hauptverfasser:	Murakami, Takaaki, Usui, Takeshi, Nakajima, Akio, Mochida, Yuki, Saito, Sumio, Nambu, Takuo, Kato, Tomoko, Matsuda, Yuki, Yonemitsu, Shin, Muro, Seiji, Oki, Shogo
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Amino Acid Substitution Diabetes Mellitus, Type 2 DNA Mutational Analysis Genetic Testing glucagonoma Glucagonoma - diagnosis Glucagonoma - genetics Glucagonoma - surgery Humans Hyperparathyroidism, Primary - diagnosis Hyperparathyroidism, Primary - etiology Hyperparathyroidism, Primary - genetics Male MEN1 menin missense mutation Multiple Endocrine Neoplasia Type 1 - diagnosis Multiple Endocrine Neoplasia Type 1 - genetics Multiple Endocrine Neoplasia Type 1 - surgery Mutation, Missense - genetics obesity Obesity - complications Pancreatic Neoplasms - diagnosis Pancreatic Neoplasms - genetics Pancreatic Neoplasms - surgery Proto-Oncogene Proteins secondary diabetes mellitus
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