Associations of cadmium, bisphenol A and polychlorinated biphenyl co-exposure in utero with placental gene expression and neonatal outcomes

•Birth weight was negatively correlated with placental Cd and cord blood PCB levels.•Positive associations were found between KISS1 expression and Cd, BPA, and PCBs.•Gender effects on the expressions of KISS1 and leptin receptor were observed.•Birth weight was negatively associated with KISS1 expres...

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Veröffentlicht in:	Reproductive toxicology (Elmsford, N.Y.) N.Y.), 2015-04, Vol.52, p.62-70
Hauptverfasser:	Xu, Xijin, Chiung, Yin Mei, Lu, Fangfang, Qiu, Shaoshan, Ji, Minhui, Huo, Xia
Format:	Artikel
Sprache:	eng
Schlagworte:	Benzhydryl Compounds - blood Benzhydryl Compounds - toxicity Birth outcomes Cadmium - blood Cadmium - toxicity Endocrine disrupting compounds Environmental Exposure - adverse effects Female Fetal Blood - chemistry Gene Expression - drug effects Humans Infant, Low Birth Weight Infant, Newborn KISS1 expression Kisspeptins - genetics Leptin - genetics Male Phenols - blood Phenols - toxicity Placenta - chemistry Placenta - drug effects Placenta - metabolism Polychlorinated Biphenyls - blood Polychlorinated Biphenyls - toxicity Pregnancy Pregnancy Outcome Prenatal exposure Prospective Studies Receptors, Leptin - genetics RNA, Messenger - analysis
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