De novo protein design: how do we expand into the universe of possible protein structures?

•The structural space explored by natural proteins is limited.•This raises questions: what protein folds are possible, and how do we access them?•Parametric protein-design methods are being developed that could explore these.•Designing symmetric α-helical bundles and coiled coils is particularly tra...

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Veröffentlicht in:	Current opinion in structural biology 2015-08, Vol.33, p.16-26
Hauptverfasser:	Woolfson, Derek N, Bartlett, Gail J, Burton, Antony J, Heal, Jack W, Niitsu, Ai, Thomson, Andrew R, Wood, Christopher W
Format:	Artikel
Sprache:	eng
Schlagworte:	Models, Molecular Protein Conformation Protein Engineering - methods Proteins - chemistry
Online-Zugang:	Volltext
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