Development of HIV-1 integrase inhibitors: recent molecular modeling perspectives

•Latest advances of HIV-1 integrase inhibitors focusing on molecular modeling.•Features and functionalities of these computational approaches.•Practices dealing with the ambiguities in drug discovery.•A general workflow of the discovery of novel inhibitors using virtual screening. Of the three viral...

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Veröffentlicht in:	Drug discovery today 2015-11, Vol.20 (11), p.1337-1348
Hauptverfasser:	Su, Min, Tan, Jianjun, Lin, Chun-Yuan
Format:	Artikel
Sprache:	eng
Schlagworte:	Computer Simulation Drug Approval Drug Design HIV Infections - drug therapy HIV Infections - enzymology HIV Integrase - drug effects HIV Integrase Inhibitors - pharmacology HIV-1 - drug effects Humans Models, Molecular Virus Replication - drug effects
Online-Zugang:	Volltext
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