Elevated guanosine 5′-diphosphate 3′-diphosphate level inhibits bacterial growth and interferes with FtsZ assembly

FtsZ, a protein essential for prokaryotic cell division, forms a ring structure known as the Z-ring at the division site. FtsZ has a GTP binding site and is assembled into linear structures in a GTP-dependent manner in vitro. We assessed whether guanosine 5′-diphosphate 3′-diphosphate (ppGpp), a glo...

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