Nigro-caudate dopaminergic deafferentation: a marker of REM sleep behavior disorder?
Abstract Forty-nine consecutive, drug naïve outpatients with de novo Parkinson's disease (PD) and 12 patients with idiopathic rapid eye movement sleep behavior disorder (iRBD) underwent clinical examination and dopamine transporter single photon emission computed tomography with [123 I]-2β-carb...
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| Veröffentlicht in: | Neurobiology of aging 2015-12, Vol.36 (12), p.3300-3305 |
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| creator | Arnaldi, Dario De Carli, Fabrizio Picco, Agnese Ferrara, Michela Accardo, Jennifer Bossert, Irene Famà, Francesco Girtler, Nicola Morbelli, Silvia Sambuceti, Gianmario Nobili, Flavio |
| description | Abstract Forty-nine consecutive, drug naïve outpatients with de novo Parkinson's disease (PD) and 12 patients with idiopathic rapid eye movement sleep behavior disorder (iRBD) underwent clinical examination and dopamine transporter single photon emission computed tomography with [123 I]-2β-carbomethoxy-3β-(4-iodophenyl)- N -(3-fluoropropyl)nortropane as a biomarker of nigro-striatal function. PD patients were grouped into rapid eye movement sleep behavior disorder (RBD) negative (PD-RBD−) and RBD positive (PD-RBD+). Repeated measures and univariate analysis of variance were used to compare dopaminergic and clinical impairment among groups. The variations of dopamine transporter–single photon emission computed tomography specific binding ratios (SBR) as a function of group belonging were significantly different ( p = 0.0013) at caudate with respect to putamen level. Indeed, putamen SBR progressively decreased from iRBD to PD-RBD− and PD-RBD+ groups while caudate SBR were higher in PD-RBD− group than in PD-RBD+ and even than in iRBD group. Motor impairment was more severe in PD patients with RBD than in those without RBD. Our data suggest that a more severe nigro-caudate dopaminergic deafferentation is related to RBD, both in its idiopathic form and in PD patients. |
| doi_str_mv | 10.1016/j.neurobiolaging.2015.08.025 |
| format | Article |
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PD patients were grouped into rapid eye movement sleep behavior disorder (RBD) negative (PD-RBD−) and RBD positive (PD-RBD+). Repeated measures and univariate analysis of variance were used to compare dopaminergic and clinical impairment among groups. The variations of dopamine transporter–single photon emission computed tomography specific binding ratios (SBR) as a function of group belonging were significantly different ( p = 0.0013) at caudate with respect to putamen level. Indeed, putamen SBR progressively decreased from iRBD to PD-RBD− and PD-RBD+ groups while caudate SBR were higher in PD-RBD− group than in PD-RBD+ and even than in iRBD group. Motor impairment was more severe in PD patients with RBD than in those without RBD. Our data suggest that a more severe nigro-caudate dopaminergic deafferentation is related to RBD, both in its idiopathic form and in PD patients.</description><identifier>ISSN: 0197-4580</identifier><identifier>EISSN: 1558-1497</identifier><identifier>DOI: 10.1016/j.neurobiolaging.2015.08.025</identifier><identifier>PMID: 26410306</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Aged ; Aged, 80 and over ; Biomarkers - metabolism ; Caudate Nucleus - metabolism ; Dopamine - metabolism ; Dopamine Plasma Membrane Transport Proteins - metabolism ; Female ; Humans ; Internal Medicine ; Male ; Middle Aged ; Neurology ; Parkinson Disease - complications ; Parkinson's disease ; REM sleep behavior disorder ; REM Sleep Behavior Disorder - complications ; REM Sleep Behavior Disorder - diagnosis ; Severity of Illness Index ; SPECT ; Substantia Nigra - metabolism ; Tomography, Emission-Computed, Single-Photon</subject><ispartof>Neurobiology of aging, 2015-12, Vol.36 (12), p.3300-3305</ispartof><rights>Elsevier Inc.</rights><rights>2015 Elsevier Inc.</rights><rights>Copyright © 2015 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c511t-47d274cfb725cdcbbe9557a61359b7e2a6c1a53dad37f2ddbe64157ab89935403</citedby><cites>FETCH-LOGICAL-c511t-47d274cfb725cdcbbe9557a61359b7e2a6c1a53dad37f2ddbe64157ab89935403</cites><orcidid>0000-0001-6823-6069</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.neurobiolaging.2015.08.025$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26410306$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Arnaldi, Dario</creatorcontrib><creatorcontrib>De Carli, Fabrizio</creatorcontrib><creatorcontrib>Picco, Agnese</creatorcontrib><creatorcontrib>Ferrara, Michela</creatorcontrib><creatorcontrib>Accardo, Jennifer</creatorcontrib><creatorcontrib>Bossert, Irene</creatorcontrib><creatorcontrib>Famà, Francesco</creatorcontrib><creatorcontrib>Girtler, Nicola</creatorcontrib><creatorcontrib>Morbelli, Silvia</creatorcontrib><creatorcontrib>Sambuceti, Gianmario</creatorcontrib><creatorcontrib>Nobili, Flavio</creatorcontrib><title>Nigro-caudate dopaminergic deafferentation: a marker of REM sleep behavior disorder?</title><title>Neurobiology of aging</title><addtitle>Neurobiol Aging</addtitle><description>Abstract Forty-nine consecutive, drug naïve outpatients with de novo Parkinson's disease (PD) and 12 patients with idiopathic rapid eye movement sleep behavior disorder (iRBD) underwent clinical examination and dopamine transporter single photon emission computed tomography with [123 I]-2β-carbomethoxy-3β-(4-iodophenyl)- N -(3-fluoropropyl)nortropane as a biomarker of nigro-striatal function. PD patients were grouped into rapid eye movement sleep behavior disorder (RBD) negative (PD-RBD−) and RBD positive (PD-RBD+). Repeated measures and univariate analysis of variance were used to compare dopaminergic and clinical impairment among groups. The variations of dopamine transporter–single photon emission computed tomography specific binding ratios (SBR) as a function of group belonging were significantly different ( p = 0.0013) at caudate with respect to putamen level. Indeed, putamen SBR progressively decreased from iRBD to PD-RBD− and PD-RBD+ groups while caudate SBR were higher in PD-RBD− group than in PD-RBD+ and even than in iRBD group. Motor impairment was more severe in PD patients with RBD than in those without RBD. Our data suggest that a more severe nigro-caudate dopaminergic deafferentation is related to RBD, both in its idiopathic form and in PD patients.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biomarkers - metabolism</subject><subject>Caudate Nucleus - metabolism</subject><subject>Dopamine - metabolism</subject><subject>Dopamine Plasma Membrane Transport Proteins - metabolism</subject><subject>Female</subject><subject>Humans</subject><subject>Internal Medicine</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Neurology</subject><subject>Parkinson Disease - complications</subject><subject>Parkinson's disease</subject><subject>REM sleep behavior disorder</subject><subject>REM Sleep Behavior Disorder - complications</subject><subject>REM Sleep Behavior Disorder - diagnosis</subject><subject>Severity of Illness Index</subject><subject>SPECT</subject><subject>Substantia Nigra - metabolism</subject><subject>Tomography, Emission-Computed, Single-Photon</subject><issn>0197-4580</issn><issn>1558-1497</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkU1v1DAQhi0EotvCX0A-cOCSMHbsOEEIVFUtIBWQoEjcLH9MFm-z8WInlfrv8WoLEj31NJdn3pl5hpCXDGoGrH29qSdcUrQhjmYdpnXNgckauhq4fERWTMquYqJXj8kKWK8qITs4Isc5bwBACdU-JUe8FQwaaFfk6ktYp1g5s3gzI_VxZ7ZhwrQOjno0w4AJp9nMIU5vqKFbk64x0TjQb-efaR4Rd9TiL3MTYqI-5Jg8pvfPyJPBjBmf39UT8uPi_OrsY3X59cOns9PLyknG5kooz5Vwg1VcOu-sxV5KZVrWyN4q5KZ1zMjGG9-ogXtvsaxdANv1fSMFNCfk1SF3l-LvBfOstyE7HEczYVyyZqrhsm-5kAV9e0BdijknHPQuhXLNrWag9171Rv_vVe-9auh08VraX9xNWuwW_b_mvyILcHEAsNx7EzDp7AJODn1I6GbtY3jopHf3gtwYpuDMeI23mDdxSVNxqpnOXIP-vv_x_sVMAgjBfzZ_AGqtp6Y</recordid><startdate>20151201</startdate><enddate>20151201</enddate><creator>Arnaldi, Dario</creator><creator>De Carli, Fabrizio</creator><creator>Picco, Agnese</creator><creator>Ferrara, Michela</creator><creator>Accardo, Jennifer</creator><creator>Bossert, Irene</creator><creator>Famà, Francesco</creator><creator>Girtler, Nicola</creator><creator>Morbelli, Silvia</creator><creator>Sambuceti, Gianmario</creator><creator>Nobili, Flavio</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-6823-6069</orcidid></search><sort><creationdate>20151201</creationdate><title>Nigro-caudate dopaminergic deafferentation: a marker of REM sleep behavior disorder?</title><author>Arnaldi, Dario ; De Carli, Fabrizio ; Picco, Agnese ; Ferrara, Michela ; Accardo, Jennifer ; Bossert, Irene ; Famà, Francesco ; Girtler, Nicola ; Morbelli, Silvia ; Sambuceti, Gianmario ; Nobili, Flavio</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c511t-47d274cfb725cdcbbe9557a61359b7e2a6c1a53dad37f2ddbe64157ab89935403</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biomarkers - metabolism</topic><topic>Caudate Nucleus - metabolism</topic><topic>Dopamine - metabolism</topic><topic>Dopamine Plasma Membrane Transport Proteins - metabolism</topic><topic>Female</topic><topic>Humans</topic><topic>Internal Medicine</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Neurology</topic><topic>Parkinson Disease - complications</topic><topic>Parkinson's disease</topic><topic>REM sleep behavior disorder</topic><topic>REM Sleep Behavior Disorder - complications</topic><topic>REM Sleep Behavior Disorder - diagnosis</topic><topic>Severity of Illness Index</topic><topic>SPECT</topic><topic>Substantia Nigra - metabolism</topic><topic>Tomography, Emission-Computed, Single-Photon</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Arnaldi, Dario</creatorcontrib><creatorcontrib>De Carli, Fabrizio</creatorcontrib><creatorcontrib>Picco, Agnese</creatorcontrib><creatorcontrib>Ferrara, Michela</creatorcontrib><creatorcontrib>Accardo, Jennifer</creatorcontrib><creatorcontrib>Bossert, Irene</creatorcontrib><creatorcontrib>Famà, Francesco</creatorcontrib><creatorcontrib>Girtler, Nicola</creatorcontrib><creatorcontrib>Morbelli, Silvia</creatorcontrib><creatorcontrib>Sambuceti, Gianmario</creatorcontrib><creatorcontrib>Nobili, Flavio</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Neurobiology of aging</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Arnaldi, Dario</au><au>De Carli, Fabrizio</au><au>Picco, Agnese</au><au>Ferrara, Michela</au><au>Accardo, Jennifer</au><au>Bossert, Irene</au><au>Famà, Francesco</au><au>Girtler, Nicola</au><au>Morbelli, Silvia</au><au>Sambuceti, Gianmario</au><au>Nobili, Flavio</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Nigro-caudate dopaminergic deafferentation: a marker of REM sleep behavior disorder?</atitle><jtitle>Neurobiology of aging</jtitle><addtitle>Neurobiol Aging</addtitle><date>2015-12-01</date><risdate>2015</risdate><volume>36</volume><issue>12</issue><spage>3300</spage><epage>3305</epage><pages>3300-3305</pages><issn>0197-4580</issn><eissn>1558-1497</eissn><abstract>Abstract Forty-nine consecutive, drug naïve outpatients with de novo Parkinson's disease (PD) and 12 patients with idiopathic rapid eye movement sleep behavior disorder (iRBD) underwent clinical examination and dopamine transporter single photon emission computed tomography with [123 I]-2β-carbomethoxy-3β-(4-iodophenyl)- N -(3-fluoropropyl)nortropane as a biomarker of nigro-striatal function. PD patients were grouped into rapid eye movement sleep behavior disorder (RBD) negative (PD-RBD−) and RBD positive (PD-RBD+). Repeated measures and univariate analysis of variance were used to compare dopaminergic and clinical impairment among groups. The variations of dopamine transporter–single photon emission computed tomography specific binding ratios (SBR) as a function of group belonging were significantly different ( p = 0.0013) at caudate with respect to putamen level. Indeed, putamen SBR progressively decreased from iRBD to PD-RBD− and PD-RBD+ groups while caudate SBR were higher in PD-RBD− group than in PD-RBD+ and even than in iRBD group. Motor impairment was more severe in PD patients with RBD than in those without RBD. 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| subjects | Aged Aged, 80 and over Biomarkers - metabolism Caudate Nucleus - metabolism Dopamine - metabolism Dopamine Plasma Membrane Transport Proteins - metabolism Female Humans Internal Medicine Male Middle Aged Neurology Parkinson Disease - complications Parkinson's disease REM sleep behavior disorder REM Sleep Behavior Disorder - complications REM Sleep Behavior Disorder - diagnosis Severity of Illness Index SPECT Substantia Nigra - metabolism Tomography, Emission-Computed, Single-Photon |
| title | Nigro-caudate dopaminergic deafferentation: a marker of REM sleep behavior disorder? |
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