Chemomimetic Biocatalysis: Exploiting the Synthetic Potential of Cofactor-Dependent Enzymes To Create New Catalysts

Despite the astonishing breadth of enzymes in nature, no enzymes are known for many of the valuable catalytic transformations discovered by chemists. Recent work in enzyme design and evolution, however, gives us good reason to think that this will change. We describe a chemomimetic biocatalysis appr...

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Veröffentlicht in:	Journal of the American Chemical Society 2015-11, Vol.137 (44), p.13992-14006
Hauptverfasser:	Prier, Christopher K, Arnold, Frances H
Format:	Artikel
Sprache:	eng
Schlagworte:	Biocatalysis - drug effects Coenzymes - chemical synthesis Coenzymes - chemistry Coenzymes - metabolism Coenzymes - pharmacology Enzymes - chemistry Enzymes - metabolism Models, Molecular Molecular Structure Small Molecule Libraries - chemical synthesis Small Molecule Libraries - chemistry Small Molecule Libraries - metabolism Small Molecule Libraries - pharmacology
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