c-Jun N-terminal kinases (JNKs) mediate pro-inflammatory actions of microglia

The activation and function of c‐Jun N‐terminal kinases (JNKs) were investigated in primary microglia cultures from neonatal rat brain, which express all three JNK isoforms. Lipopolysaccharide (LPS), tumor necrosis factor‐α (TNF‐α), and thrombin preparations induced a rapid and lasting activation of...

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Veröffentlicht in:	Glia 2005-05, Vol.50 (3), p.235-246
Hauptverfasser:	Waetzig, Vicki, Czeloth, Karen, Hidding, Ute, Mielke, Kirsten, Kanzow, Moritz, Brecht, Stephan, Goetz, Mario, Lucius, Ralph, Herdegen, Thomas, Hanisch, Uwe-Karsten
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Newborn Biological and medical sciences c-Jun Cell Nucleus - drug effects Cell Nucleus - enzymology Cells, Cultured Chemokines - metabolism cyclooxygenase Cytoplasm - drug effects Cytoplasm - enzymology Encephalitis - chemically induced Encephalitis - enzymology Encephalitis - physiopathology Enzyme Activation - drug effects Enzyme Activation - physiology Enzyme Inhibitors - pharmacology ERK Extracellular Signal-Regulated MAP Kinases - metabolism Extracellular Signal-Regulated MAP Kinases - pharmacology Fundamental and applied biological sciences. Psychology Gliosis - chemically induced Gliosis - enzymology Gliosis - physiopathology IL-6 Inflammation Mediators - metabolism Isolated neuron and nerve. Neuroglia JNK Mitogen-Activated Protein Kinases - drug effects JNK Mitogen-Activated Protein Kinases - metabolism Lipopolysaccharides - pharmacology LPS Microglia - drug effects Microglia - enzymology Mitogen-Activated Protein Kinase 8 - metabolism Mitogen-Activated Protein Kinase 9 - metabolism p38 p38 Mitogen-Activated Protein Kinases - metabolism p38 Mitogen-Activated Protein Kinases - pharmacology Proto-Oncogene Proteins c-jun - metabolism Rats thrombin Thrombin - pharmacology TNF-α Tumor Necrosis Factor-alpha - pharmacology Vertebrates: nervous system and sense organs
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