Prospective evaluation of gut mucosal barrier injury following various myeloablative regimens for haematopoietic stem cell transplant
We determined gut mucosal barrier injury (MBI) among 129 recipients of an allogeneic or autologous haematopoietic stem cell transplant (HSCT) who had been given different myeloablative regimens by measuring integrity using the lactulose/rhamnose (RHA) ratio and absorption using the ratios of rhamnos...
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| Veröffentlicht in: | Bone marrow transplantation (Basingstoke) 2005-04, Vol.35 (7), p.707-711 |
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| creator | BLIJLEVENS, N. M. A DONNELLY, J. P DE PAUW, B. E |
| description | We determined gut mucosal barrier injury (MBI) among 129 recipients of an allogeneic or autologous haematopoietic stem cell transplant (HSCT) who had been given different myeloablative regimens by measuring integrity using the lactulose/rhamnose (RHA) ratio and absorption using the ratios of rhamnose/3-O-methylglucose and xylose/3-O-methylglucose. Regimens that did not contain idarubicin induced oral mucositis and disturbed gut integrity and absorption earlier than did those containing the anthracycline. By contrast, regimens containing idarubicin induced more severe and prolonged oral and gut MBI. Gut integrity and absorption of most patients were still abnormal at discharge from hospital. These results confirm that the integrity and absorptive capacity of the gut is affected adversely by myeloablative regimens in general, although only two patterns of mucosal injury emerged depending on whether or not idarubicin was used. |
| doi_str_mv | 10.1038/sj.bmt.1704863 |
| format | Article |
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M. A ; DONNELLY, J. P ; DE PAUW, B. E</creator><creatorcontrib>BLIJLEVENS, N. M. A ; DONNELLY, J. P ; DE PAUW, B. E</creatorcontrib><description>We determined gut mucosal barrier injury (MBI) among 129 recipients of an allogeneic or autologous haematopoietic stem cell transplant (HSCT) who had been given different myeloablative regimens by measuring integrity using the lactulose/rhamnose (RHA) ratio and absorption using the ratios of rhamnose/3-O-methylglucose and xylose/3-O-methylglucose. Regimens that did not contain idarubicin induced oral mucositis and disturbed gut integrity and absorption earlier than did those containing the anthracycline. By contrast, regimens containing idarubicin induced more severe and prolonged oral and gut MBI. Gut integrity and absorption of most patients were still abnormal at discharge from hospital. These results confirm that the integrity and absorptive capacity of the gut is affected adversely by myeloablative regimens in general, although only two patterns of mucosal injury emerged depending on whether or not idarubicin was used.</description><identifier>ISSN: 0268-3369</identifier><identifier>EISSN: 1476-5365</identifier><identifier>DOI: 10.1038/sj.bmt.1704863</identifier><identifier>PMID: 15785771</identifier><identifier>CODEN: BMTRE9</identifier><language>eng</language><publisher>Basingstoke: Nature Publishing Group</publisher><subject>Absorption ; Absorptivity ; Adult ; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Anthracycline ; Anthracyclines - adverse effects ; Antineoplastic Agents - adverse effects ; Autografts ; Biological and medical sciences ; Bone marrow ; Bone marrow, stem cells transplantation. Graft versus host reaction ; Causes of ; Complications and side effects ; Dosage and administration ; Female ; Hematologic Neoplasms - complications ; Hematologic Neoplasms - therapy ; Hematopoietic Stem Cell Transplantation - adverse effects ; Hematopoietic Stem Cell Transplantation - methods ; Hematopoietic stem cells ; Humans ; Idarubicin ; Idarubicin - adverse effects ; Injuries ; Integrity ; Intestinal Mucosa - drug effects ; Intestinal Mucosa - metabolism ; Intestinal Mucosa - pathology ; Lactulose ; Lactulose - metabolism ; Lactulose - urine ; Male ; Medical sciences ; Middle Aged ; Mucosa ; Mucositis ; Myeloablative Agonists - adverse effects ; Permeability - drug effects ; Prevention ; Prospective Studies ; Rhamnose ; Rhamnose - metabolism ; Rhamnose - urine ; Stem cell transplantation ; Stem cells ; Stomatitis ; Stomatitis - chemically induced ; Transfusions. Complications. Transfusion reactions. Cell and gene therapy ; Transplantation ; Transplantation Conditioning - adverse effects</subject><ispartof>Bone marrow transplantation (Basingstoke), 2005-04, Vol.35 (7), p.707-711</ispartof><rights>2005 INIST-CNRS</rights><rights>COPYRIGHT 2005 Nature Publishing Group</rights><rights>Copyright Nature Publishing Group Apr 2005</rights><rights>Nature Publishing Group 2005.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c613t-1f1f89fdd6fecc8020b202184cf72789f4a9aad2bc3d0045f523f31dcd1762bb3</citedby><cites>FETCH-LOGICAL-c613t-1f1f89fdd6fecc8020b202184cf72789f4a9aad2bc3d0045f523f31dcd1762bb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16649601$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15785771$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>BLIJLEVENS, N. M. A</creatorcontrib><creatorcontrib>DONNELLY, J. P</creatorcontrib><creatorcontrib>DE PAUW, B. E</creatorcontrib><title>Prospective evaluation of gut mucosal barrier injury following various myeloablative regimens for haematopoietic stem cell transplant</title><title>Bone marrow transplantation (Basingstoke)</title><addtitle>Bone Marrow Transplant</addtitle><description>We determined gut mucosal barrier injury (MBI) among 129 recipients of an allogeneic or autologous haematopoietic stem cell transplant (HSCT) who had been given different myeloablative regimens by measuring integrity using the lactulose/rhamnose (RHA) ratio and absorption using the ratios of rhamnose/3-O-methylglucose and xylose/3-O-methylglucose. Regimens that did not contain idarubicin induced oral mucositis and disturbed gut integrity and absorption earlier than did those containing the anthracycline. By contrast, regimens containing idarubicin induced more severe and prolonged oral and gut MBI. Gut integrity and absorption of most patients were still abnormal at discharge from hospital. These results confirm that the integrity and absorptive capacity of the gut is affected adversely by myeloablative regimens in general, although only two patterns of mucosal injury emerged depending on whether or not idarubicin was used.</description><subject>Absorption</subject><subject>Absorptivity</subject><subject>Adult</subject><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Anthracycline</subject><subject>Anthracyclines - adverse effects</subject><subject>Antineoplastic Agents - adverse effects</subject><subject>Autografts</subject><subject>Biological and medical sciences</subject><subject>Bone marrow</subject><subject>Bone marrow, stem cells transplantation. Graft versus host reaction</subject><subject>Causes of</subject><subject>Complications and side effects</subject><subject>Dosage and administration</subject><subject>Female</subject><subject>Hematologic Neoplasms - complications</subject><subject>Hematologic Neoplasms - therapy</subject><subject>Hematopoietic Stem Cell Transplantation - adverse effects</subject><subject>Hematopoietic Stem Cell Transplantation - methods</subject><subject>Hematopoietic stem cells</subject><subject>Humans</subject><subject>Idarubicin</subject><subject>Idarubicin - adverse effects</subject><subject>Injuries</subject><subject>Integrity</subject><subject>Intestinal Mucosa - drug effects</subject><subject>Intestinal Mucosa - metabolism</subject><subject>Intestinal Mucosa - pathology</subject><subject>Lactulose</subject><subject>Lactulose - metabolism</subject><subject>Lactulose - urine</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Mucosa</subject><subject>Mucositis</subject><subject>Myeloablative Agonists - adverse effects</subject><subject>Permeability - drug effects</subject><subject>Prevention</subject><subject>Prospective Studies</subject><subject>Rhamnose</subject><subject>Rhamnose - metabolism</subject><subject>Rhamnose - urine</subject><subject>Stem cell transplantation</subject><subject>Stem cells</subject><subject>Stomatitis</subject><subject>Stomatitis - chemically induced</subject><subject>Transfusions. 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Graft versus host reaction</topic><topic>Causes of</topic><topic>Complications and side effects</topic><topic>Dosage and administration</topic><topic>Female</topic><topic>Hematologic Neoplasms - complications</topic><topic>Hematologic Neoplasms - therapy</topic><topic>Hematopoietic Stem Cell Transplantation - adverse effects</topic><topic>Hematopoietic Stem Cell Transplantation - methods</topic><topic>Hematopoietic stem cells</topic><topic>Humans</topic><topic>Idarubicin</topic><topic>Idarubicin - adverse effects</topic><topic>Injuries</topic><topic>Integrity</topic><topic>Intestinal Mucosa - drug effects</topic><topic>Intestinal Mucosa - metabolism</topic><topic>Intestinal Mucosa - pathology</topic><topic>Lactulose</topic><topic>Lactulose - metabolism</topic><topic>Lactulose - urine</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Mucosa</topic><topic>Mucositis</topic><topic>Myeloablative Agonists - adverse effects</topic><topic>Permeability - drug effects</topic><topic>Prevention</topic><topic>Prospective Studies</topic><topic>Rhamnose</topic><topic>Rhamnose - metabolism</topic><topic>Rhamnose - urine</topic><topic>Stem cell transplantation</topic><topic>Stem cells</topic><topic>Stomatitis</topic><topic>Stomatitis - chemically induced</topic><topic>Transfusions. 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M. A</au><au>DONNELLY, J. P</au><au>DE PAUW, B. E</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prospective evaluation of gut mucosal barrier injury following various myeloablative regimens for haematopoietic stem cell transplant</atitle><jtitle>Bone marrow transplantation (Basingstoke)</jtitle><addtitle>Bone Marrow Transplant</addtitle><date>2005-04-01</date><risdate>2005</risdate><volume>35</volume><issue>7</issue><spage>707</spage><epage>711</epage><pages>707-711</pages><issn>0268-3369</issn><eissn>1476-5365</eissn><coden>BMTRE9</coden><abstract>We determined gut mucosal barrier injury (MBI) among 129 recipients of an allogeneic or autologous haematopoietic stem cell transplant (HSCT) who had been given different myeloablative regimens by measuring integrity using the lactulose/rhamnose (RHA) ratio and absorption using the ratios of rhamnose/3-O-methylglucose and xylose/3-O-methylglucose. Regimens that did not contain idarubicin induced oral mucositis and disturbed gut integrity and absorption earlier than did those containing the anthracycline. By contrast, regimens containing idarubicin induced more severe and prolonged oral and gut MBI. Gut integrity and absorption of most patients were still abnormal at discharge from hospital. These results confirm that the integrity and absorptive capacity of the gut is affected adversely by myeloablative regimens in general, although only two patterns of mucosal injury emerged depending on whether or not idarubicin was used.</abstract><cop>Basingstoke</cop><pub>Nature Publishing Group</pub><pmid>15785771</pmid><doi>10.1038/sj.bmt.1704863</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Bone marrow transplantation (Basingstoke), 2005-04, Vol.35 (7), p.707-711 |
| issn | 0268-3369 1476-5365 |
| language | eng |
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| source | MEDLINE; Springer Nature - Complete Springer Journals; Nature Journals Online; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Absorption Absorptivity Adult Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Anthracycline Anthracyclines - adverse effects Antineoplastic Agents - adverse effects Autografts Biological and medical sciences Bone marrow Bone marrow, stem cells transplantation. Graft versus host reaction Causes of Complications and side effects Dosage and administration Female Hematologic Neoplasms - complications Hematologic Neoplasms - therapy Hematopoietic Stem Cell Transplantation - adverse effects Hematopoietic Stem Cell Transplantation - methods Hematopoietic stem cells Humans Idarubicin Idarubicin - adverse effects Injuries Integrity Intestinal Mucosa - drug effects Intestinal Mucosa - metabolism Intestinal Mucosa - pathology Lactulose Lactulose - metabolism Lactulose - urine Male Medical sciences Middle Aged Mucosa Mucositis Myeloablative Agonists - adverse effects Permeability - drug effects Prevention Prospective Studies Rhamnose Rhamnose - metabolism Rhamnose - urine Stem cell transplantation Stem cells Stomatitis Stomatitis - chemically induced Transfusions. Complications. Transfusion reactions. Cell and gene therapy Transplantation Transplantation Conditioning - adverse effects |
| title | Prospective evaluation of gut mucosal barrier injury following various myeloablative regimens for haematopoietic stem cell transplant |
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