Fluorescent Copolymer-Based Prodrug for pH-Triggered Intracellular Release of DOX

A novel water-soluble pH stimuli-responsive fluorescent copolymer of P(PEGMA-b-(MAH-co-Rh6GEAm)) was synthesized by two-step sequential RAFT polymerization. The prodrug with drug content of 0.1560 mg/mg was prepared by coupling doxorubicin (DOX) onto the copolymer via acid-cleavable hydrazone bond,...

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Veröffentlicht in:	Biomacromolecules 2015-11, Vol.16 (11), p.3624-3631
Hauptverfasser:	Jia, Xu, Zhao, Xubo, Tian, Kun, Zhou, Tingting, Li, Jiagen, Zhang, Ruinian, Liu, Peng
Format:	Artikel
Sprache:	eng
Schlagworte:	Biocompatible Materials - chemistry Biocompatible Materials - pharmacology Doxorubicin - chemistry Doxorubicin - pharmacology Drug Carriers - chemistry Fluorescence Hep G2 Cells Humans Hydrazones - chemistry Hydrogen-Ion Concentration Methacrylates - chemistry Methacrylates - pharmacology Micelles Molecular Weight Polyethylene Glycols - chemistry Polyethylene Glycols - pharmacology Polymerization Polymers - chemistry Polymers - pharmacology Prodrugs - chemistry Prodrugs - pharmacology
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