Synthesis of Unsymmetrical Sulfides and Their Oxidation to Sulfones to Discover Potent Antileishmanial Agents

Unsymmetrical sulfides were first synthesized using combinations of a 1,3-dicarbonyl, an aromatic aldehyde and a thiol in the presence of 10 mol % ethanolic piperidine. These sulfides derivatives were subsequently converted into corresponding sulfones via oxidation in the presence of m-chloroperoxyb...

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Veröffentlicht in:	ACS combinatorial science 2015-11, Vol.17 (11), p.671-681
Hauptverfasser:	Dar, Ajaz A, Enjamuri, Nagasuresh, Shadab, Md, Ali, Nahid, Khan, Abu T
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antiprotozoal Agents - chemical synthesis Antiprotozoal Agents - chemistry Antiprotozoal Agents - pharmacology Cell Survival - drug effects Cells, Cultured Combinatorial Chemistry Techniques Cricetinae Dose-Response Relationship, Drug Drug Discovery Humans Leishmania donovani - drug effects Macrophages - drug effects Macrophages - parasitology Mice Mice, Inbred BALB C Models, Molecular Molecular Structure Oxidation-Reduction Parasitic Sensitivity Tests Structure-Activity Relationship Sulfides - chemical synthesis Sulfides - chemistry Sulfides - pharmacology Sulfones - chemical synthesis Sulfones - chemistry Sulfones - pharmacology
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