Synthetic biology design to display an 18 kDa rotavirus large antigen on a modular virus-like particle
Highlights • Molecular dynamics simulated large antigen modularization on virus-like particle. • Longer flanking linkers provided flexibility for the display of large antigen. • Modular virus-like particles obtained with module titration strategy.
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| Veröffentlicht in: | Vaccine 2015-11, Vol.33 (44), p.5937-5944 |
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| container_end_page | 5944 |
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| container_issue | 44 |
| container_start_page | 5937 |
| container_title | Vaccine |
| container_volume | 33 |
| creator | Lua, Linda H.L Fan, Yuanyuan Chang, Cindy Connors, Natalie K Middelberg, Anton P.J |
| description | Highlights • Molecular dynamics simulated large antigen modularization on virus-like particle. • Longer flanking linkers provided flexibility for the display of large antigen. • Modular virus-like particles obtained with module titration strategy. |
| doi_str_mv | 10.1016/j.vaccine.2015.09.017 |
| format | Article |
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| ispartof | Vaccine, 2015-11, Vol.33 (44), p.5937-5944 |
| issn | 0264-410X 1873-2518 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete; ProQuest Central |
| subjects | Allergy and Immunology Antigens, Viral - chemistry Antigens, Viral - genetics Genetic Vectors Molecular Dynamics Simulation Polyomavirus - genetics Protein Engineering - methods Rotavirus - genetics Rotavirus Vaccines - chemistry Rotavirus Vaccines - genetics Vaccines, Virus-Like Particle - chemistry Vaccines, Virus-Like Particle - genetics |
| title | Synthetic biology design to display an 18 kDa rotavirus large antigen on a modular virus-like particle |
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