Small-size Microparticles as Indicators of Acute Decompensated State in Ischemic Heart Failure
Abstract Introduction and objectives Microparticles are markers for cell activation and apoptosis and could provide valuable information that is not available from clinical data. This study assesses the clinical and biological relationship of small-sized microparticles in different forms of ischemic...
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| Veröffentlicht in: | Revista española de cardiología (English ed.) 2015-11, Vol.68 (11), p.951-958 |
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| creator | Montoro-García, Silvia Shantsila, Eduard Wrigley, Benjamin J Tapp, Luke D Abellán Alemán, José Lip, Gregory Y.H |
| description | Abstract Introduction and objectives Microparticles are markers for cell activation and apoptosis and could provide valuable information that is not available from clinical data. This study assesses the clinical and biological relationship of small-sized microparticles in different forms of ischemic systolic heart failure and their relation to markers of inflammation and repair. Methods We compared 49 patients with acute heart failure, 39 with stable heart failure and 25 patients with stable coronary artery disease. Small-size microparticles counts were determined by high-resolution flow cytometry. Moreover, 3 different monocyte subpopulations and their expression of inflammatory and adhesive scavenger receptors were analyzed using a conventional flow cytometer. Results Endothelial CD144+ microparticle counts were decreased in heart failure groups ( P = .008). Annexin V-binding microparticle counts were found increased in heart failure ( P = .024) and in patients with lower functional class ( P = .013). Platelet CD42b+ microparticle counts positively correlated with left ventricular ejection fraction ( P = .006), and annexin V-binding microparticle counts with interleukin-6 levels in stable heart failure ( P = .034). Annexin V-binding microparticle counts in the acute status strongly correlated with toll-like receptor-4 expression on all monocyte subsets (all P < .01). Three months after admission with acute heart failure, annexin V-binding microparticle counts were positively correlated with receptors for interleukin-6, CD163 and CD204 (all P < .05). Conclusions Annexin V-binding microparticle counts constitute valuable hallmarks of acute decompensated state in systolic heart failure. The observed relationship between small-size annexin V-binding microparticles and scavenger receptors supports their involvement in the progression of the acute response to injury, and thus their contribution to the pathogenesis of acute decompensated heart failure. |
| doi_str_mv | 10.1016/j.rec.2014.11.016 |
| format | Article |
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This study assesses the clinical and biological relationship of small-sized microparticles in different forms of ischemic systolic heart failure and their relation to markers of inflammation and repair. Methods We compared 49 patients with acute heart failure, 39 with stable heart failure and 25 patients with stable coronary artery disease. Small-size microparticles counts were determined by high-resolution flow cytometry. Moreover, 3 different monocyte subpopulations and their expression of inflammatory and adhesive scavenger receptors were analyzed using a conventional flow cytometer. Results Endothelial CD144+ microparticle counts were decreased in heart failure groups ( P = .008). Annexin V-binding microparticle counts were found increased in heart failure ( P = .024) and in patients with lower functional class ( P = .013). Platelet CD42b+ microparticle counts positively correlated with left ventricular ejection fraction ( P = .006), and annexin V-binding microparticle counts with interleukin-6 levels in stable heart failure ( P = .034). Annexin V-binding microparticle counts in the acute status strongly correlated with toll-like receptor-4 expression on all monocyte subsets (all P < .01). Three months after admission with acute heart failure, annexin V-binding microparticle counts were positively correlated with receptors for interleukin-6, CD163 and CD204 (all P < .05). Conclusions Annexin V-binding microparticle counts constitute valuable hallmarks of acute decompensated state in systolic heart failure. The observed relationship between small-size annexin V-binding microparticles and scavenger receptors supports their involvement in the progression of the acute response to injury, and thus their contribution to the pathogenesis of acute decompensated heart failure.</description><identifier>ISSN: 1885-5857</identifier><identifier>EISSN: 1885-5857</identifier><identifier>DOI: 10.1016/j.rec.2014.11.016</identifier><identifier>PMID: 25819989</identifier><language>eng</language><publisher>Spain</publisher><subject>Aged ; Annexin A5 ; Antigens, CD ; Antigens, Differentiation, Myelomonocytic ; Apoptosis ; Biomarkers ; Blood Platelets - cytology ; Blood Platelets - metabolism ; Cadherins ; Cardiovascular ; Case-Control Studies ; Cell-Derived Microparticles - metabolism ; Coronary Artery Disease - metabolism ; Endothelial Cells - cytology ; Endothelial Cells - metabolism ; Female ; Flow Cytometry ; Heart Failure - etiology ; Heart Failure - metabolism ; Humans ; Internal Medicine ; Male ; Middle Aged ; Monocytes - cytology ; Monocytes - metabolism ; Myocardial Ischemia - complications ; Myocardial Ischemia - metabolism ; Platelet Glycoprotein GPIb-IX Complex ; Prospective Studies ; Receptors, Cell Surface ; Receptors, Interleukin-6 ; Receptors, Scavenger ; Scavenger Receptors, Class A ; Stroke Volume ; Toll-Like Receptor 4</subject><ispartof>Revista española de cardiología (English ed.), 2015-11, Vol.68 (11), p.951-958</ispartof><rights>Sociedad Española de Cardiología</rights><rights>Copyright © 2014 Sociedad Española de Cardiología. Published by Elsevier España, S.L.U. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c286t-6cafb562b808ba0d8ac4f4bc269f13c1db3b7f755f1a35ed51098dee89f08f483</citedby><cites>FETCH-LOGICAL-c286t-6cafb562b808ba0d8ac4f4bc269f13c1db3b7f755f1a35ed51098dee89f08f483</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25819989$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Montoro-García, Silvia</creatorcontrib><creatorcontrib>Shantsila, Eduard</creatorcontrib><creatorcontrib>Wrigley, Benjamin J</creatorcontrib><creatorcontrib>Tapp, Luke D</creatorcontrib><creatorcontrib>Abellán Alemán, José</creatorcontrib><creatorcontrib>Lip, Gregory Y.H</creatorcontrib><title>Small-size Microparticles as Indicators of Acute Decompensated State in Ischemic Heart Failure</title><title>Revista española de cardiología (English ed.)</title><addtitle>Rev Esp Cardiol (Engl Ed)</addtitle><description>Abstract Introduction and objectives Microparticles are markers for cell activation and apoptosis and could provide valuable information that is not available from clinical data. This study assesses the clinical and biological relationship of small-sized microparticles in different forms of ischemic systolic heart failure and their relation to markers of inflammation and repair. Methods We compared 49 patients with acute heart failure, 39 with stable heart failure and 25 patients with stable coronary artery disease. Small-size microparticles counts were determined by high-resolution flow cytometry. Moreover, 3 different monocyte subpopulations and their expression of inflammatory and adhesive scavenger receptors were analyzed using a conventional flow cytometer. Results Endothelial CD144+ microparticle counts were decreased in heart failure groups ( P = .008). Annexin V-binding microparticle counts were found increased in heart failure ( P = .024) and in patients with lower functional class ( P = .013). Platelet CD42b+ microparticle counts positively correlated with left ventricular ejection fraction ( P = .006), and annexin V-binding microparticle counts with interleukin-6 levels in stable heart failure ( P = .034). Annexin V-binding microparticle counts in the acute status strongly correlated with toll-like receptor-4 expression on all monocyte subsets (all P < .01). Three months after admission with acute heart failure, annexin V-binding microparticle counts were positively correlated with receptors for interleukin-6, CD163 and CD204 (all P < .05). Conclusions Annexin V-binding microparticle counts constitute valuable hallmarks of acute decompensated state in systolic heart failure. The observed relationship between small-size annexin V-binding microparticles and scavenger receptors supports their involvement in the progression of the acute response to injury, and thus their contribution to the pathogenesis of acute decompensated heart failure.</description><subject>Aged</subject><subject>Annexin A5</subject><subject>Antigens, CD</subject><subject>Antigens, Differentiation, Myelomonocytic</subject><subject>Apoptosis</subject><subject>Biomarkers</subject><subject>Blood Platelets - cytology</subject><subject>Blood Platelets - metabolism</subject><subject>Cadherins</subject><subject>Cardiovascular</subject><subject>Case-Control Studies</subject><subject>Cell-Derived Microparticles - metabolism</subject><subject>Coronary Artery Disease - metabolism</subject><subject>Endothelial Cells - cytology</subject><subject>Endothelial Cells - metabolism</subject><subject>Female</subject><subject>Flow Cytometry</subject><subject>Heart Failure - etiology</subject><subject>Heart Failure - metabolism</subject><subject>Humans</subject><subject>Internal Medicine</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Monocytes - cytology</subject><subject>Monocytes - metabolism</subject><subject>Myocardial Ischemia - complications</subject><subject>Myocardial Ischemia - metabolism</subject><subject>Platelet Glycoprotein GPIb-IX Complex</subject><subject>Prospective Studies</subject><subject>Receptors, Cell Surface</subject><subject>Receptors, Interleukin-6</subject><subject>Receptors, Scavenger</subject><subject>Scavenger Receptors, Class A</subject><subject>Stroke Volume</subject><subject>Toll-Like Receptor 4</subject><issn>1885-5857</issn><issn>1885-5857</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkc1r3DAQxUVpyFfzB_QSdOzFzoxt2fKlEPK5kNDDttcKWR5RbWV7K9mB9K-Plk1CTjMMbx6832PsK0KOgPXFJg9k8gKwyhHzdPnEjlFKkQkpms8f9iN2EuMGQJSyqQ7ZUSEktq1sj9nv9aC9z6L7T_zRmTBtdZid8RS5jnw19s7oeQqRT5ZfmmUmfk1mGrY0Rj1Tz9dzGtyNfBXNHxqc4feUHPitdn4J9IUdWO0jnb3OU_br9ubn1X328ONudXX5kJlC1nNWG207URedBNlp6KU2la06U9StxdJg35VdYxshLOpSUC8QWtkTydaCtJUsT9m3ve82TP8WirMaXDTkvR5pWqLCpixKaKCpkhT30hQ2xkBWbYMbdHhWCGqHVW1Uwqp2WBWiSpf0c_5qv3QD9e8fbxyT4PteQCnkk6OgjHdjYuf_0jPFzbSEMeVXqGKhQK13zeyKQQEAVQHlC1kgid8</recordid><startdate>20151101</startdate><enddate>20151101</enddate><creator>Montoro-García, Silvia</creator><creator>Shantsila, Eduard</creator><creator>Wrigley, Benjamin J</creator><creator>Tapp, Luke D</creator><creator>Abellán Alemán, José</creator><creator>Lip, Gregory Y.H</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20151101</creationdate><title>Small-size Microparticles as Indicators of Acute Decompensated State in Ischemic Heart Failure</title><author>Montoro-García, Silvia ; Shantsila, Eduard ; Wrigley, Benjamin J ; Tapp, Luke D ; Abellán Alemán, José ; Lip, Gregory Y.H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c286t-6cafb562b808ba0d8ac4f4bc269f13c1db3b7f755f1a35ed51098dee89f08f483</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Aged</topic><topic>Annexin A5</topic><topic>Antigens, CD</topic><topic>Antigens, Differentiation, Myelomonocytic</topic><topic>Apoptosis</topic><topic>Biomarkers</topic><topic>Blood Platelets - cytology</topic><topic>Blood Platelets - metabolism</topic><topic>Cadherins</topic><topic>Cardiovascular</topic><topic>Case-Control Studies</topic><topic>Cell-Derived Microparticles - metabolism</topic><topic>Coronary Artery Disease - metabolism</topic><topic>Endothelial Cells - cytology</topic><topic>Endothelial Cells - metabolism</topic><topic>Female</topic><topic>Flow Cytometry</topic><topic>Heart Failure - etiology</topic><topic>Heart Failure - metabolism</topic><topic>Humans</topic><topic>Internal Medicine</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Monocytes - cytology</topic><topic>Monocytes - metabolism</topic><topic>Myocardial Ischemia - complications</topic><topic>Myocardial Ischemia - metabolism</topic><topic>Platelet Glycoprotein GPIb-IX Complex</topic><topic>Prospective Studies</topic><topic>Receptors, Cell Surface</topic><topic>Receptors, Interleukin-6</topic><topic>Receptors, Scavenger</topic><topic>Scavenger Receptors, Class A</topic><topic>Stroke Volume</topic><topic>Toll-Like Receptor 4</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Montoro-García, Silvia</creatorcontrib><creatorcontrib>Shantsila, Eduard</creatorcontrib><creatorcontrib>Wrigley, Benjamin J</creatorcontrib><creatorcontrib>Tapp, Luke D</creatorcontrib><creatorcontrib>Abellán Alemán, José</creatorcontrib><creatorcontrib>Lip, Gregory Y.H</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Revista española de cardiología (English ed.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Montoro-García, Silvia</au><au>Shantsila, Eduard</au><au>Wrigley, Benjamin J</au><au>Tapp, Luke D</au><au>Abellán Alemán, José</au><au>Lip, Gregory Y.H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Small-size Microparticles as Indicators of Acute Decompensated State in Ischemic Heart Failure</atitle><jtitle>Revista española de cardiología (English ed.)</jtitle><addtitle>Rev Esp Cardiol (Engl Ed)</addtitle><date>2015-11-01</date><risdate>2015</risdate><volume>68</volume><issue>11</issue><spage>951</spage><epage>958</epage><pages>951-958</pages><issn>1885-5857</issn><eissn>1885-5857</eissn><abstract>Abstract Introduction and objectives Microparticles are markers for cell activation and apoptosis and could provide valuable information that is not available from clinical data. This study assesses the clinical and biological relationship of small-sized microparticles in different forms of ischemic systolic heart failure and their relation to markers of inflammation and repair. Methods We compared 49 patients with acute heart failure, 39 with stable heart failure and 25 patients with stable coronary artery disease. Small-size microparticles counts were determined by high-resolution flow cytometry. Moreover, 3 different monocyte subpopulations and their expression of inflammatory and adhesive scavenger receptors were analyzed using a conventional flow cytometer. Results Endothelial CD144+ microparticle counts were decreased in heart failure groups ( P = .008). Annexin V-binding microparticle counts were found increased in heart failure ( P = .024) and in patients with lower functional class ( P = .013). Platelet CD42b+ microparticle counts positively correlated with left ventricular ejection fraction ( P = .006), and annexin V-binding microparticle counts with interleukin-6 levels in stable heart failure ( P = .034). Annexin V-binding microparticle counts in the acute status strongly correlated with toll-like receptor-4 expression on all monocyte subsets (all P < .01). Three months after admission with acute heart failure, annexin V-binding microparticle counts were positively correlated with receptors for interleukin-6, CD163 and CD204 (all P < .05). Conclusions Annexin V-binding microparticle counts constitute valuable hallmarks of acute decompensated state in systolic heart failure. The observed relationship between small-size annexin V-binding microparticles and scavenger receptors supports their involvement in the progression of the acute response to injury, and thus their contribution to the pathogenesis of acute decompensated heart failure.</abstract><cop>Spain</cop><pmid>25819989</pmid><doi>10.1016/j.rec.2014.11.016</doi><tpages>8</tpages></addata></record> |
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| subjects | Aged Annexin A5 Antigens, CD Antigens, Differentiation, Myelomonocytic Apoptosis Biomarkers Blood Platelets - cytology Blood Platelets - metabolism Cadherins Cardiovascular Case-Control Studies Cell-Derived Microparticles - metabolism Coronary Artery Disease - metabolism Endothelial Cells - cytology Endothelial Cells - metabolism Female Flow Cytometry Heart Failure - etiology Heart Failure - metabolism Humans Internal Medicine Male Middle Aged Monocytes - cytology Monocytes - metabolism Myocardial Ischemia - complications Myocardial Ischemia - metabolism Platelet Glycoprotein GPIb-IX Complex Prospective Studies Receptors, Cell Surface Receptors, Interleukin-6 Receptors, Scavenger Scavenger Receptors, Class A Stroke Volume Toll-Like Receptor 4 |
| title | Small-size Microparticles as Indicators of Acute Decompensated State in Ischemic Heart Failure |
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