Abnormal regulation of DNA methyltransferase expression during colorectal carcinogenesis

Somatic changes in CpG dinucleotide methylation occur quite commonly in human cancer cell DNA. Relative to DNA from normal human colonic cells, DNA from human colorectal cancer cells typically displays regional CpG dinucleotide hypermethylation amid global CpG dinucleotide hypomethylation. The role...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 1999-08, Vol.59 (16), p.3855-3860
Hauptverfasser:	DE MARZO, A. M, MARCHI, V. L, YANG, E. S, VEERASWAMY, R, XIAOHUI LIN, NELSON, W. G
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Colon - enzymology Colorectal Neoplasms - enzymology Colorectal Neoplasms - genetics DNA Methylation DNA Modification Methylases - biosynthesis DNA Modification Methylases - genetics DNA Replication DNA, Neoplasm - genetics Gastroenterology. Liver. Pancreas. Abdomen Gene Expression Regulation, Enzymologic Gene Expression Regulation, Neoplastic Humans Immunohistochemistry Medical sciences Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Tumors
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