HLA-G-mediated inhibition of antigen-specific cytotoxic T lymphocytes
In the present study, we demonstrate that the non-classical MHC class I molecule HLA-G impairs specific cytolytic T cell functions in addition to its well-established inhibition of NK lysis. The antigen-specific cytotoxic T lymphocyte (CTL) response analyzed was mediated by CD8+ T cells specific for...
Gespeichert in:
| Veröffentlicht in: | International immunology 1999-08, Vol.11 (8), p.1351-1356 |
|---|---|
| Hauptverfasser: | , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1356 |
|---|---|
| container_issue | 8 |
| container_start_page | 1351 |
| container_title | International immunology |
| container_volume | 11 |
| creator | Le Gal, Frédérique-Anne Riteau, Béatrice Sedlik, Christine Khalil-Daher, Iman Menier, Catherine Dausset, Jean Guillet, Jean-Gérard Carosella, Edgardo D. Rouas-Freiss, Nathalie |
| description | In the present study, we demonstrate that the non-classical MHC class I molecule HLA-G impairs specific cytolytic T cell functions in addition to its well-established inhibition of NK lysis. The antigen-specific cytotoxic T lymphocyte (CTL) response analyzed was mediated by CD8+ T cells specific for the influenza virus matrix epitope, M58–66, presented by HLA-A2. The transfection of HLA-G1 cDNA in target cells carrying the M58–66 epitope reduced their lysis by these virus-specific CTL. This HLA-G-mediated inhibition of antigen-specific CTL lysis was (i) peptide dose dependent, (ii) reversed by blocking HLA-G with a specific mAb and (iii) still observed despite the blockade of HLA-E/CD94/NKG2A interaction. By inhibiting both CTL and NK functions, HLA-G appears to have an extensive role in immune tolerance. |
| doi_str_mv | 10.1093/intimm/11.8.1351 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_17319477</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>43820440</sourcerecordid><originalsourceid>FETCH-LOGICAL-c462t-50fee4673522bf070fb87ac69fbf8e0aa4fb51b294f9daf79478b23aaea3200e3</originalsourceid><addsrcrecordid>eNpdkDtPwzAURi0EgvLYmVDEwOZyr53E8cirLaKIpUiIxXJSGwxNXOJUav89roIQYvKV7_k-2YeQU4QhguSXrulcXV8iDosh8gx3yADTHCjjQuySAciM0wJFcUAOQ_gAAM4k3ycHCClDIdmA3E2mV3RMazN3ujPzxDXvrnSd803ibaJj_5tpaFiayllXJdWm851fx2mWLDb18t3HGxOOyZ7Vi2BOfs4j8jy6m91M6PRpfH9zNaVVmrOOZmCNSXPBM8ZKCwJsWQhd5dKWtjCgdWrLDEsmUyvn2gqZiqJkXGujOQMw_Ihc9L3L1n-tTOhU7UJlFgvdGL8KCgXHGBIRPP8HfvhV28S3KZQZYJ6lMkLQQ1XrQ2iNVcvW1brdKAS19at6vwpRFWrrN0bOfnpXZXT2J9ALjQDtARc6s_7d6_ZTxX-LTE1eXtVUytHjw_WtGvNvjZqGrQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>195016549</pqid></control><display><type>article</type><title>HLA-G-mediated inhibition of antigen-specific cytotoxic T lymphocytes</title><source>MEDLINE</source><source>Oxford University Press Journals All Titles (1996-Current)</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Alma/SFX Local Collection</source><creator>Le Gal, Frédérique-Anne ; Riteau, Béatrice ; Sedlik, Christine ; Khalil-Daher, Iman ; Menier, Catherine ; Dausset, Jean ; Guillet, Jean-Gérard ; Carosella, Edgardo D. ; Rouas-Freiss, Nathalie</creator><creatorcontrib>Le Gal, Frédérique-Anne ; Riteau, Béatrice ; Sedlik, Christine ; Khalil-Daher, Iman ; Menier, Catherine ; Dausset, Jean ; Guillet, Jean-Gérard ; Carosella, Edgardo D. ; Rouas-Freiss, Nathalie</creatorcontrib><description>In the present study, we demonstrate that the non-classical MHC class I molecule HLA-G impairs specific cytolytic T cell functions in addition to its well-established inhibition of NK lysis. The antigen-specific cytotoxic T lymphocyte (CTL) response analyzed was mediated by CD8+ T cells specific for the influenza virus matrix epitope, M58–66, presented by HLA-A2. The transfection of HLA-G1 cDNA in target cells carrying the M58–66 epitope reduced their lysis by these virus-specific CTL. This HLA-G-mediated inhibition of antigen-specific CTL lysis was (i) peptide dose dependent, (ii) reversed by blocking HLA-G with a specific mAb and (iii) still observed despite the blockade of HLA-E/CD94/NKG2A interaction. By inhibiting both CTL and NK functions, HLA-G appears to have an extensive role in immune tolerance.</description><identifier>ISSN: 0953-8178</identifier><identifier>EISSN: 1460-2377</identifier><identifier>DOI: 10.1093/intimm/11.8.1351</identifier><identifier>PMID: 10421792</identifier><language>eng</language><publisher>England: Oxford University Press</publisher><subject>Blotting, Western ; CD8-Positive T-Lymphocytes - immunology ; CTL cytotoxic T lymphocyte ; Cytotoxicity Tests, Immunologic ; Epitopes ; Flow Cytometry ; Histocompatibility Antigens Class I - immunology ; HLA Antigens - immunology ; HLA-G Antigens ; HLA human leukocyte antigen ; Humans ; Immune Tolerance ; immunotolerance ; Influenza A virus - chemistry ; Influenza A virus - immunology ; Killer Cells, Natural - immunology ; killer inhibitory receptor ; KIR killer inhibitory receptor ; Peptide Fragments - immunology ; Receptors, Immunologic - immunology ; Receptors, Immunologic - metabolism ; T-Lymphocytes, Cytotoxic - immunology ; Tumor Cells, Cultured ; Viral Matrix Proteins - immunology</subject><ispartof>International immunology, 1999-08, Vol.11 (8), p.1351-1356</ispartof><rights>Copyright Oxford University Press Aug 1999</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c462t-50fee4673522bf070fb87ac69fbf8e0aa4fb51b294f9daf79478b23aaea3200e3</citedby><cites>FETCH-LOGICAL-c462t-50fee4673522bf070fb87ac69fbf8e0aa4fb51b294f9daf79478b23aaea3200e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10421792$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Le Gal, Frédérique-Anne</creatorcontrib><creatorcontrib>Riteau, Béatrice</creatorcontrib><creatorcontrib>Sedlik, Christine</creatorcontrib><creatorcontrib>Khalil-Daher, Iman</creatorcontrib><creatorcontrib>Menier, Catherine</creatorcontrib><creatorcontrib>Dausset, Jean</creatorcontrib><creatorcontrib>Guillet, Jean-Gérard</creatorcontrib><creatorcontrib>Carosella, Edgardo D.</creatorcontrib><creatorcontrib>Rouas-Freiss, Nathalie</creatorcontrib><title>HLA-G-mediated inhibition of antigen-specific cytotoxic T lymphocytes</title><title>International immunology</title><addtitle>Int. Immunol</addtitle><description>In the present study, we demonstrate that the non-classical MHC class I molecule HLA-G impairs specific cytolytic T cell functions in addition to its well-established inhibition of NK lysis. The antigen-specific cytotoxic T lymphocyte (CTL) response analyzed was mediated by CD8+ T cells specific for the influenza virus matrix epitope, M58–66, presented by HLA-A2. The transfection of HLA-G1 cDNA in target cells carrying the M58–66 epitope reduced their lysis by these virus-specific CTL. This HLA-G-mediated inhibition of antigen-specific CTL lysis was (i) peptide dose dependent, (ii) reversed by blocking HLA-G with a specific mAb and (iii) still observed despite the blockade of HLA-E/CD94/NKG2A interaction. By inhibiting both CTL and NK functions, HLA-G appears to have an extensive role in immune tolerance.</description><subject>Blotting, Western</subject><subject>CD8-Positive T-Lymphocytes - immunology</subject><subject>CTL cytotoxic T lymphocyte</subject><subject>Cytotoxicity Tests, Immunologic</subject><subject>Epitopes</subject><subject>Flow Cytometry</subject><subject>Histocompatibility Antigens Class I - immunology</subject><subject>HLA Antigens - immunology</subject><subject>HLA-G Antigens</subject><subject>HLA human leukocyte antigen</subject><subject>Humans</subject><subject>Immune Tolerance</subject><subject>immunotolerance</subject><subject>Influenza A virus - chemistry</subject><subject>Influenza A virus - immunology</subject><subject>Killer Cells, Natural - immunology</subject><subject>killer inhibitory receptor</subject><subject>KIR killer inhibitory receptor</subject><subject>Peptide Fragments - immunology</subject><subject>Receptors, Immunologic - immunology</subject><subject>Receptors, Immunologic - metabolism</subject><subject>T-Lymphocytes, Cytotoxic - immunology</subject><subject>Tumor Cells, Cultured</subject><subject>Viral Matrix Proteins - immunology</subject><issn>0953-8178</issn><issn>1460-2377</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkDtPwzAURi0EgvLYmVDEwOZyr53E8cirLaKIpUiIxXJSGwxNXOJUav89roIQYvKV7_k-2YeQU4QhguSXrulcXV8iDosh8gx3yADTHCjjQuySAciM0wJFcUAOQ_gAAM4k3ycHCClDIdmA3E2mV3RMazN3ujPzxDXvrnSd803ibaJj_5tpaFiayllXJdWm851fx2mWLDb18t3HGxOOyZ7Vi2BOfs4j8jy6m91M6PRpfH9zNaVVmrOOZmCNSXPBM8ZKCwJsWQhd5dKWtjCgdWrLDEsmUyvn2gqZiqJkXGujOQMw_Ihc9L3L1n-tTOhU7UJlFgvdGL8KCgXHGBIRPP8HfvhV28S3KZQZYJ6lMkLQQ1XrQ2iNVcvW1brdKAS19at6vwpRFWrrN0bOfnpXZXT2J9ALjQDtARc6s_7d6_ZTxX-LTE1eXtVUytHjw_WtGvNvjZqGrQ</recordid><startdate>19990801</startdate><enddate>19990801</enddate><creator>Le Gal, Frédérique-Anne</creator><creator>Riteau, Béatrice</creator><creator>Sedlik, Christine</creator><creator>Khalil-Daher, Iman</creator><creator>Menier, Catherine</creator><creator>Dausset, Jean</creator><creator>Guillet, Jean-Gérard</creator><creator>Carosella, Edgardo D.</creator><creator>Rouas-Freiss, Nathalie</creator><general>Oxford University Press</general><general>Oxford Publishing Limited (England)</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7T5</scope><scope>7T7</scope><scope>7TK</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>P64</scope></search><sort><creationdate>19990801</creationdate><title>HLA-G-mediated inhibition of antigen-specific cytotoxic T lymphocytes</title><author>Le Gal, Frédérique-Anne ; Riteau, Béatrice ; Sedlik, Christine ; Khalil-Daher, Iman ; Menier, Catherine ; Dausset, Jean ; Guillet, Jean-Gérard ; Carosella, Edgardo D. ; Rouas-Freiss, Nathalie</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c462t-50fee4673522bf070fb87ac69fbf8e0aa4fb51b294f9daf79478b23aaea3200e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Blotting, Western</topic><topic>CD8-Positive T-Lymphocytes - immunology</topic><topic>CTL cytotoxic T lymphocyte</topic><topic>Cytotoxicity Tests, Immunologic</topic><topic>Epitopes</topic><topic>Flow Cytometry</topic><topic>Histocompatibility Antigens Class I - immunology</topic><topic>HLA Antigens - immunology</topic><topic>HLA-G Antigens</topic><topic>HLA human leukocyte antigen</topic><topic>Humans</topic><topic>Immune Tolerance</topic><topic>immunotolerance</topic><topic>Influenza A virus - chemistry</topic><topic>Influenza A virus - immunology</topic><topic>Killer Cells, Natural - immunology</topic><topic>killer inhibitory receptor</topic><topic>KIR killer inhibitory receptor</topic><topic>Peptide Fragments - immunology</topic><topic>Receptors, Immunologic - immunology</topic><topic>Receptors, Immunologic - metabolism</topic><topic>T-Lymphocytes, Cytotoxic - immunology</topic><topic>Tumor Cells, Cultured</topic><topic>Viral Matrix Proteins - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Le Gal, Frédérique-Anne</creatorcontrib><creatorcontrib>Riteau, Béatrice</creatorcontrib><creatorcontrib>Sedlik, Christine</creatorcontrib><creatorcontrib>Khalil-Daher, Iman</creatorcontrib><creatorcontrib>Menier, Catherine</creatorcontrib><creatorcontrib>Dausset, Jean</creatorcontrib><creatorcontrib>Guillet, Jean-Gérard</creatorcontrib><creatorcontrib>Carosella, Edgardo D.</creatorcontrib><creatorcontrib>Rouas-Freiss, Nathalie</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Immunology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>International immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Le Gal, Frédérique-Anne</au><au>Riteau, Béatrice</au><au>Sedlik, Christine</au><au>Khalil-Daher, Iman</au><au>Menier, Catherine</au><au>Dausset, Jean</au><au>Guillet, Jean-Gérard</au><au>Carosella, Edgardo D.</au><au>Rouas-Freiss, Nathalie</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>HLA-G-mediated inhibition of antigen-specific cytotoxic T lymphocytes</atitle><jtitle>International immunology</jtitle><addtitle>Int. Immunol</addtitle><date>1999-08-01</date><risdate>1999</risdate><volume>11</volume><issue>8</issue><spage>1351</spage><epage>1356</epage><pages>1351-1356</pages><issn>0953-8178</issn><eissn>1460-2377</eissn><abstract>In the present study, we demonstrate that the non-classical MHC class I molecule HLA-G impairs specific cytolytic T cell functions in addition to its well-established inhibition of NK lysis. The antigen-specific cytotoxic T lymphocyte (CTL) response analyzed was mediated by CD8+ T cells specific for the influenza virus matrix epitope, M58–66, presented by HLA-A2. The transfection of HLA-G1 cDNA in target cells carrying the M58–66 epitope reduced their lysis by these virus-specific CTL. This HLA-G-mediated inhibition of antigen-specific CTL lysis was (i) peptide dose dependent, (ii) reversed by blocking HLA-G with a specific mAb and (iii) still observed despite the blockade of HLA-E/CD94/NKG2A interaction. By inhibiting both CTL and NK functions, HLA-G appears to have an extensive role in immune tolerance.</abstract><cop>England</cop><pub>Oxford University Press</pub><pmid>10421792</pmid><doi>10.1093/intimm/11.8.1351</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0953-8178 |
| ispartof | International immunology, 1999-08, Vol.11 (8), p.1351-1356 |
| issn | 0953-8178 1460-2377 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_17319477 |
| source | MEDLINE; Oxford University Press Journals All Titles (1996-Current); EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Blotting, Western CD8-Positive T-Lymphocytes - immunology CTL cytotoxic T lymphocyte Cytotoxicity Tests, Immunologic Epitopes Flow Cytometry Histocompatibility Antigens Class I - immunology HLA Antigens - immunology HLA-G Antigens HLA human leukocyte antigen Humans Immune Tolerance immunotolerance Influenza A virus - chemistry Influenza A virus - immunology Killer Cells, Natural - immunology killer inhibitory receptor KIR killer inhibitory receptor Peptide Fragments - immunology Receptors, Immunologic - immunology Receptors, Immunologic - metabolism T-Lymphocytes, Cytotoxic - immunology Tumor Cells, Cultured Viral Matrix Proteins - immunology |
| title | HLA-G-mediated inhibition of antigen-specific cytotoxic T lymphocytes |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-22T20%3A41%3A22IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=HLA-G-mediated%20inhibition%20of%20antigen-specific%20cytotoxic%20T%20lymphocytes&rft.jtitle=International%20immunology&rft.au=Le%20Gal,%20Fre%CC%81de%CC%81rique-Anne&rft.date=1999-08-01&rft.volume=11&rft.issue=8&rft.spage=1351&rft.epage=1356&rft.pages=1351-1356&rft.issn=0953-8178&rft.eissn=1460-2377&rft_id=info:doi/10.1093/intimm/11.8.1351&rft_dat=%3Cproquest_cross%3E43820440%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=195016549&rft_id=info:pmid/10421792&rfr_iscdi=true |