Targeted Disruption of CDK4 Delays Cell Cycle Entry with Enhanced p27 super(Kip1) Activity

The mechanism by which cyclin-dependent kinase 4 (CDK4) regulates cell cycle progression is not entirely clear. Cyclin D/CDK4 appears to initiate phosphorylation of retinoblastoma protein (Rb) leading to inactivation of the S-phase-inhibitory action of Rb. However, cyclin D/CDK4 has been postulated...

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Veröffentlicht in:	Molecular and cellular biology 1999-10, Vol.19 (10), p.7011-7019
Hauptverfasser:	Tsutsui, T, Hesabi, B, Moons, D S, Pandolfi, P P, Hansel, K S, Koff, A, Kiyokawa, H
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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