The role of cyclooxygenase-2 and prostaglandin E2 in the pathogenesis of cutaneous lichen planus
Summary Background Lichen planus (LP) is an inflammatory disease of the skin and mucous membranes. Autoimmunity has been suggested as a possible cause of this disease. The cyclooxygenase enzymes (COX‐1, COX‐2) are the key enzymes in the conversion of arachidonic acid into prostaglandins. Prostagland...
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| Veröffentlicht in: | Clinical and experimental dermatology 2015-12, Vol.40 (8), p.903-907 |
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| container_title | Clinical and experimental dermatology |
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| creator | El-Rifaie, A. A. Rashed, L. A. Doss, R. W. |
| description | Summary
Background
Lichen planus (LP) is an inflammatory disease of the skin and mucous membranes. Autoimmunity has been suggested as a possible cause of this disease. The cyclooxygenase enzymes (COX‐1, COX‐2) are the key enzymes in the conversion of arachidonic acid into prostaglandins. Prostaglandin E2 (PGE2), a key product of COX‐2, has an immunomodulatory role.
Aim
To map levels of COX‐2 and PGE2 in cutaneous LP lesions and evaluate their role in the pathogenesis of the disease.
Methods
In total, 31 patients with classic cutaneous LP and 30 age‐ and sex‐matched healthy controls were enrolled. Skin biopsies were taken from the lesional and nonlesional skin of patients, and from the normal skin of controls. COX‐2 mRNA expression was detected by real‐time reverse transcription quantitative PCR, and PGE2 was detected by ELISA in skin biopsies from patients and controls.
Results
Our analysis revealed a significantly higher expression of COX‐2 mRNA and PGE2 in the LP skin biopsies compared with the control biopsies (P |
| doi_str_mv | 10.1111/ced.12663 |
| format | Article |
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Background
Lichen planus (LP) is an inflammatory disease of the skin and mucous membranes. Autoimmunity has been suggested as a possible cause of this disease. The cyclooxygenase enzymes (COX‐1, COX‐2) are the key enzymes in the conversion of arachidonic acid into prostaglandins. Prostaglandin E2 (PGE2), a key product of COX‐2, has an immunomodulatory role.
Aim
To map levels of COX‐2 and PGE2 in cutaneous LP lesions and evaluate their role in the pathogenesis of the disease.
Methods
In total, 31 patients with classic cutaneous LP and 30 age‐ and sex‐matched healthy controls were enrolled. Skin biopsies were taken from the lesional and nonlesional skin of patients, and from the normal skin of controls. COX‐2 mRNA expression was detected by real‐time reverse transcription quantitative PCR, and PGE2 was detected by ELISA in skin biopsies from patients and controls.
Results
Our analysis revealed a significantly higher expression of COX‐2 mRNA and PGE2 in the LP skin biopsies compared with the control biopsies (P < 0.001 and P < 0.001, respectively). Lesional biopsies showed significantly higher expression of COX‐2 mRNA and PGE2 compared with nonlesional biopsies. The levels of COX‐2 and PGE2 were not found to be correlated with age, sex or disease duration.
Conclusions
COX‐2 and its product PGE2 are strongly expressed in LP skin lesions, indicating that they have a role in the pathogenesis of LP through their immunomodulatory effects.</description><identifier>ISSN: 0307-6938</identifier><identifier>EISSN: 1365-2230</identifier><identifier>DOI: 10.1111/ced.12663</identifier><identifier>PMID: 25980490</identifier><identifier>CODEN: CEDEDE</identifier><language>eng</language><publisher>England: Blackwell Publishing Ltd</publisher><subject>Adult ; Case-Control Studies ; Cyclooxygenase 2 - metabolism ; Dinoprostone - metabolism ; Female ; Humans ; Lichen Planus - etiology ; Lichen Planus - metabolism ; Male ; Middle Aged ; Real-Time Polymerase Chain Reaction ; RNA, Messenger - metabolism ; Skin - metabolism ; Young Adult</subject><ispartof>Clinical and experimental dermatology, 2015-12, Vol.40 (8), p.903-907</ispartof><rights>2015 British Association of Dermatologists</rights><rights>2015 British Association of Dermatologists.</rights><rights>Copyright © 2015 British Association of Dermatologists</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4613-935e7d1b73e9303353fbf1dd00685e55ef98909240b87a5f71dd289b931dac83</citedby><cites>FETCH-LOGICAL-c4613-935e7d1b73e9303353fbf1dd00685e55ef98909240b87a5f71dd289b931dac83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25980490$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>El-Rifaie, A. A.</creatorcontrib><creatorcontrib>Rashed, L. A.</creatorcontrib><creatorcontrib>Doss, R. W.</creatorcontrib><title>The role of cyclooxygenase-2 and prostaglandin E2 in the pathogenesis of cutaneous lichen planus</title><title>Clinical and experimental dermatology</title><addtitle>Clin Exp Dermatol</addtitle><description>Summary
Background
Lichen planus (LP) is an inflammatory disease of the skin and mucous membranes. Autoimmunity has been suggested as a possible cause of this disease. The cyclooxygenase enzymes (COX‐1, COX‐2) are the key enzymes in the conversion of arachidonic acid into prostaglandins. Prostaglandin E2 (PGE2), a key product of COX‐2, has an immunomodulatory role.
Aim
To map levels of COX‐2 and PGE2 in cutaneous LP lesions and evaluate their role in the pathogenesis of the disease.
Methods
In total, 31 patients with classic cutaneous LP and 30 age‐ and sex‐matched healthy controls were enrolled. Skin biopsies were taken from the lesional and nonlesional skin of patients, and from the normal skin of controls. COX‐2 mRNA expression was detected by real‐time reverse transcription quantitative PCR, and PGE2 was detected by ELISA in skin biopsies from patients and controls.
Results
Our analysis revealed a significantly higher expression of COX‐2 mRNA and PGE2 in the LP skin biopsies compared with the control biopsies (P < 0.001 and P < 0.001, respectively). Lesional biopsies showed significantly higher expression of COX‐2 mRNA and PGE2 compared with nonlesional biopsies. The levels of COX‐2 and PGE2 were not found to be correlated with age, sex or disease duration.
Conclusions
COX‐2 and its product PGE2 are strongly expressed in LP skin lesions, indicating that they have a role in the pathogenesis of LP through their immunomodulatory effects.</description><subject>Adult</subject><subject>Case-Control Studies</subject><subject>Cyclooxygenase 2 - metabolism</subject><subject>Dinoprostone - metabolism</subject><subject>Female</subject><subject>Humans</subject><subject>Lichen Planus - etiology</subject><subject>Lichen Planus - metabolism</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Real-Time Polymerase Chain Reaction</subject><subject>RNA, Messenger - metabolism</subject><subject>Skin - metabolism</subject><subject>Young Adult</subject><issn>0307-6938</issn><issn>1365-2230</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kMFP2zAUxq0JNDq2w_4BZInLOKTYfrUdH6euMCQol0rbzXOSFxpIkxIngv73eyOUwyR8sC3793363sfYVymmktZ5jsVUKmPgA5tIMDpRCsQBmwgQNjEO0iP2KcZ7ISRIqz-yI6VdKmZOTNif1Rp519bI25Lnu7xu2-fdHTYhYqJ4aAq-7drYh7ua7lXDF4rT3pNoG_p1SyTGKr6Ihz402A6R11W-xoZvSTLEz-ywDHXEL6_nMVtdLFbzn8n17eXV_Pt1ks-MhMSBRlvIzAI6EAAayqyURSGESTVqjaVLnXBqJrLUBl1a-lOpyxzIIuQpHLNvoy3FfRww9n5TxRzreszkpaXRHSg1I_T0P_S-HbqGwhGlHIEUhqizkcpp_thh6bddtQndzkvh_7XuqXX_0jqxJ6-OQ7ah1z25r5mA8xF4qmrcve_k54sfe8tkVFSxx-c3RegevLFgtf-1vPTmwix_O7jxK_gLRNOZNw</recordid><startdate>201512</startdate><enddate>201512</enddate><creator>El-Rifaie, A. A.</creator><creator>Rashed, L. A.</creator><creator>Doss, R. W.</creator><general>Blackwell Publishing Ltd</general><general>Oxford University Press</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>201512</creationdate><title>The role of cyclooxygenase-2 and prostaglandin E2 in the pathogenesis of cutaneous lichen planus</title><author>El-Rifaie, A. A. ; Rashed, L. A. ; Doss, R. W.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4613-935e7d1b73e9303353fbf1dd00685e55ef98909240b87a5f71dd289b931dac83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adult</topic><topic>Case-Control Studies</topic><topic>Cyclooxygenase 2 - metabolism</topic><topic>Dinoprostone - metabolism</topic><topic>Female</topic><topic>Humans</topic><topic>Lichen Planus - etiology</topic><topic>Lichen Planus - metabolism</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Real-Time Polymerase Chain Reaction</topic><topic>RNA, Messenger - metabolism</topic><topic>Skin - metabolism</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>El-Rifaie, A. A.</creatorcontrib><creatorcontrib>Rashed, L. A.</creatorcontrib><creatorcontrib>Doss, R. W.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical and experimental dermatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>El-Rifaie, A. A.</au><au>Rashed, L. A.</au><au>Doss, R. W.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The role of cyclooxygenase-2 and prostaglandin E2 in the pathogenesis of cutaneous lichen planus</atitle><jtitle>Clinical and experimental dermatology</jtitle><addtitle>Clin Exp Dermatol</addtitle><date>2015-12</date><risdate>2015</risdate><volume>40</volume><issue>8</issue><spage>903</spage><epage>907</epage><pages>903-907</pages><issn>0307-6938</issn><eissn>1365-2230</eissn><coden>CEDEDE</coden><abstract>Summary
Background
Lichen planus (LP) is an inflammatory disease of the skin and mucous membranes. Autoimmunity has been suggested as a possible cause of this disease. The cyclooxygenase enzymes (COX‐1, COX‐2) are the key enzymes in the conversion of arachidonic acid into prostaglandins. Prostaglandin E2 (PGE2), a key product of COX‐2, has an immunomodulatory role.
Aim
To map levels of COX‐2 and PGE2 in cutaneous LP lesions and evaluate their role in the pathogenesis of the disease.
Methods
In total, 31 patients with classic cutaneous LP and 30 age‐ and sex‐matched healthy controls were enrolled. Skin biopsies were taken from the lesional and nonlesional skin of patients, and from the normal skin of controls. COX‐2 mRNA expression was detected by real‐time reverse transcription quantitative PCR, and PGE2 was detected by ELISA in skin biopsies from patients and controls.
Results
Our analysis revealed a significantly higher expression of COX‐2 mRNA and PGE2 in the LP skin biopsies compared with the control biopsies (P < 0.001 and P < 0.001, respectively). Lesional biopsies showed significantly higher expression of COX‐2 mRNA and PGE2 compared with nonlesional biopsies. The levels of COX‐2 and PGE2 were not found to be correlated with age, sex or disease duration.
Conclusions
COX‐2 and its product PGE2 are strongly expressed in LP skin lesions, indicating that they have a role in the pathogenesis of LP through their immunomodulatory effects.</abstract><cop>England</cop><pub>Blackwell Publishing Ltd</pub><pmid>25980490</pmid><doi>10.1111/ced.12663</doi><tpages>5</tpages></addata></record> |
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| ispartof | Clinical and experimental dermatology, 2015-12, Vol.40 (8), p.903-907 |
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| language | eng |
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| source | MEDLINE; Oxford University Press Journals All Titles (1996-Current); Alma/SFX Local Collection |
| subjects | Adult Case-Control Studies Cyclooxygenase 2 - metabolism Dinoprostone - metabolism Female Humans Lichen Planus - etiology Lichen Planus - metabolism Male Middle Aged Real-Time Polymerase Chain Reaction RNA, Messenger - metabolism Skin - metabolism Young Adult |
| title | The role of cyclooxygenase-2 and prostaglandin E2 in the pathogenesis of cutaneous lichen planus |
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