Long-Term Dietary Fructose Causes Gender-Different Metabolic and Vascular Dysfunction in Rats: Modulatory Effects of Resveratrol

Background/Aims: There is limited knowledge on the gender differences in the effects of dietary fructose. In the current study, we investigated whether long-term fructose intake impacts metabolic parameters and vascular reactivity differently between male and female rats. Moreover, we tested whether...

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Veröffentlicht in:	Cellular Physiology and Biochemistry 2015-01, Vol.37 (4), p.1407-1420
Hauptverfasser:	Pektaş, Mehmet Bilgehan, Sadi, Gökhan, Akar, Fatma
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholine - metabolism Animals Antioxidants - pharmacology Aorta - drug effects Aorta - metabolism Blood circulation disorders Body Weight - drug effects Care and treatment Diet eNOS Female Fructose Fructose - pharmacology Gender Health aspects iNOS Insulin Insulin - blood Insulin Receptor Substrate Proteins - genetics Insulin Receptor Substrate Proteins - metabolism Lipoproteins, VLDL - blood Male Metabolic and vascular function Nitric Oxide Synthase Type II - genetics Nitric Oxide Synthase Type II - metabolism Nitric Oxide Synthase Type III - genetics Nitric Oxide Synthase Type III - metabolism Original Paper Phenylephrine - metabolism Physiological aspects Rats Rats, Wistar Real-Time Polymerase Chain Reaction Resveratrol Sex Factors SIRT1 Sirtuin 1 - genetics Sirtuin 1 - metabolism Stilbenes - pharmacology Triglycerides - blood
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