What adaptive changes in hemagglutinin and neuraminidase are necessary for emergence of pandemic influenza virus from its avian precursor?
Wild ducks serve as the primary host for numerous and various influenza type A viruses. Occasionally, viruses from this reservoir can be transferred to other host species and cause outbreaks of influenza in fowl, swine, and horses, as well as result in novel human pandemics. Cellular tropism and ran...
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| Veröffentlicht in: | Biochemistry (Moscow) 2015-07, Vol.80 (7), p.872-880 |
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| creator | Gambaryan, A. S. Matrosovich, M. N. |
| description | Wild ducks serve as the primary host for numerous and various influenza type A viruses. Occasionally, viruses from this reservoir can be transferred to other host species and cause outbreaks of influenza in fowl, swine, and horses, as well as result in novel human pandemics. Cellular tropism and range of susceptible host species are determined by interaction between virus and receptor molecules on cells. Here we discuss modern data regarding molecular features underlying interactions of influenza viruses with cellular receptors as well as a role for receptor specificity in interspecies transmission. By analyzing the earliest available pandemic influenza viruses (1918, 1957, 1968, 2009), we found that hemagglutinin reconfigured to recognize 2-6 sialic acid-containing receptors in the human upper airway tract together with altered enzymatic activity of neuraminidase necessary for maintaining functional balance with hemagglutinin are responsible for effective spread of influenza viruses in human populations. Resistance to low pH also contributes to this. Thus, a combination of such parameters makes it possible that influenza viruses give rise to novel pandemics. |
| doi_str_mv | 10.1134/S000629791507007X |
| format | Article |
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By analyzing the earliest available pandemic influenza viruses (1918, 1957, 1968, 2009), we found that hemagglutinin reconfigured to recognize 2-6 sialic acid-containing receptors in the human upper airway tract together with altered enzymatic activity of neuraminidase necessary for maintaining functional balance with hemagglutinin are responsible for effective spread of influenza viruses in human populations. Resistance to low pH also contributes to this. 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S.</creatorcontrib><creatorcontrib>Matrosovich, M. N.</creatorcontrib><title>What adaptive changes in hemagglutinin and neuraminidase are necessary for emergence of pandemic influenza virus from its avian precursor?</title><title>Biochemistry (Moscow)</title><addtitle>Biochemistry Moscow</addtitle><addtitle>Biochemistry (Mosc)</addtitle><description>Wild ducks serve as the primary host for numerous and various influenza type A viruses. Occasionally, viruses from this reservoir can be transferred to other host species and cause outbreaks of influenza in fowl, swine, and horses, as well as result in novel human pandemics. Cellular tropism and range of susceptible host species are determined by interaction between virus and receptor molecules on cells. Here we discuss modern data regarding molecular features underlying interactions of influenza viruses with cellular receptors as well as a role for receptor specificity in interspecies transmission. By analyzing the earliest available pandemic influenza viruses (1918, 1957, 1968, 2009), we found that hemagglutinin reconfigured to recognize 2-6 sialic acid-containing receptors in the human upper airway tract together with altered enzymatic activity of neuraminidase necessary for maintaining functional balance with hemagglutinin are responsible for effective spread of influenza viruses in human populations. Resistance to low pH also contributes to this. Thus, a combination of such parameters makes it possible that influenza viruses give rise to novel pandemics.</description><subject>Amino acids</subject><subject>Analysis</subject><subject>Animals</subject><subject>Aquatic birds</subject><subject>Avian flu</subject><subject>Avian influenza viruses</subject><subject>Biochemistry</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Bioorganic Chemistry</subject><subject>Birds</subject><subject>Disease Transmission, Infectious</subject><subject>Ducks</subject><subject>Enzymatic activity</subject><subject>Epidemics</subject><subject>Health aspects</subject><subject>Hemagglutinins - genetics</subject><subject>Hemagglutinins - metabolism</subject><subject>Horses</subject><subject>Host-virus relationships</subject><subject>Human populations</subject><subject>Humans</subject><subject>Influenza</subject><subject>Influenza A virus - genetics</subject><subject>Influenza A virus - metabolism</subject><subject>Influenza A Virus, H1N1 Subtype - genetics</subject><subject>Influenza A Virus, H1N1 Subtype - metabolism</subject><subject>Influenza in Birds - transmission</subject><subject>Influenza in Birds - virology</subject><subject>Influenza virus</subject><subject>Influenza viruses</subject><subject>Influenza, Human - transmission</subject><subject>Influenza, Human - virology</subject><subject>Lectins</subject><subject>Life Sciences</subject><subject>Microbiology</subject><subject>Neuraminidase - genetics</subject><subject>Neuraminidase - metabolism</subject><subject>Observations</subject><subject>Pandemics</subject><subject>Review</subject><subject>Viral Proteins - genetics</subject><subject>Viral Proteins - metabolism</subject><subject>Viruses</subject><issn>0006-2979</issn><issn>1608-3040</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqNkstu1TAQhi0EoofCA7BBltiwSfEltpMVqipuUiUWgGAXTZxJjqvEPtjJkcoj8NQ4nALlqsoLazzf_1v-PYQ85OyEc1k-fcsY06I2NVfMMGY-3iIbrllVSFay22Sztou1f0TupXSRS8FqeZccCa1KwRjfkC8ftjBT6GA3uz1SuwU_YKLO0y1OMAzjMjufK_Ad9bhEmHLZQUIKEfOJxZQgXtI-RIoTxgG9RRp6ussKnJzNVv24oP8MdO_ikmgfw0TdnCjsHXi6i2iXmEJ8dp_c6WFM-OBqPybvXzx_d_aqOH_z8vXZ6XlhVSXmQvWt4rUttWkVtFyyrmPcQqm0EEwpzTW2RitVqlbWKJXlUAGvtDWdsKZS8pg8OfjuYvi0YJqbySWL4wgew5IabiQ3dQ6W3QBldWYlX9HHv6EXYYk-P6ThutZaaCOqn9QAIzY5mjBHsKtpc6orpo0SSv2XKqUytdLaZOrkL1Re33IPHnuXz3-xvZHg-g38ILAxpBSxb3bRTfm7G86adQKbPyYwax5d5bC0E3Y_FN9HLgPiAKTcysMWrwX1T9evoLjifA</recordid><startdate>20150701</startdate><enddate>20150701</enddate><creator>Gambaryan, A. 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Here we discuss modern data regarding molecular features underlying interactions of influenza viruses with cellular receptors as well as a role for receptor specificity in interspecies transmission. By analyzing the earliest available pandemic influenza viruses (1918, 1957, 1968, 2009), we found that hemagglutinin reconfigured to recognize 2-6 sialic acid-containing receptors in the human upper airway tract together with altered enzymatic activity of neuraminidase necessary for maintaining functional balance with hemagglutinin are responsible for effective spread of influenza viruses in human populations. Resistance to low pH also contributes to this. Thus, a combination of such parameters makes it possible that influenza viruses give rise to novel pandemics.</abstract><cop>Moscow</cop><pub>Pleiades Publishing</pub><pmid>26542001</pmid><doi>10.1134/S000629791507007X</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Biochemistry (Moscow), 2015-07, Vol.80 (7), p.872-880 |
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| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Amino acids Analysis Animals Aquatic birds Avian flu Avian influenza viruses Biochemistry Biomedical and Life Sciences Biomedicine Bioorganic Chemistry Birds Disease Transmission, Infectious Ducks Enzymatic activity Epidemics Health aspects Hemagglutinins - genetics Hemagglutinins - metabolism Horses Host-virus relationships Human populations Humans Influenza Influenza A virus - genetics Influenza A virus - metabolism Influenza A Virus, H1N1 Subtype - genetics Influenza A Virus, H1N1 Subtype - metabolism Influenza in Birds - transmission Influenza in Birds - virology Influenza virus Influenza viruses Influenza, Human - transmission Influenza, Human - virology Lectins Life Sciences Microbiology Neuraminidase - genetics Neuraminidase - metabolism Observations Pandemics Review Viral Proteins - genetics Viral Proteins - metabolism Viruses |
| title | What adaptive changes in hemagglutinin and neuraminidase are necessary for emergence of pandemic influenza virus from its avian precursor? |
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