Antiandrogen Therapy with Hydroxyflutamide or Androgen Receptor Degradation Enhancer ASC-J9 Enhances BCG Efficacy to Better Suppress Bladder Cancer Progression

Recent studies suggest that the androgen receptor (AR) might play important roles in influencing bladder cancer progression, yet its clinical application remains unclear. Here, we developed a new combined therapy with Bacillus Calmette-Guérin (BCG) and the AR degradation enhancer ASC-J9 or antiandro...

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Veröffentlicht in:	Molecular cancer therapeutics 2015-11, Vol.14 (11), p.2586-2594
Hauptverfasser:	Shang, Zhiqun, Li, Yanjun, Zhang, Minghao, Tian, Jing, Han, Ruifa, Shyr, Chih-Rong, Messing, Edward, Yeh, Shuyuan, Niu, Yuanjie, Chang, Chawnshang
Format:	Artikel
Sprache:	eng
Schlagworte:	Androgen Antagonists - administration & dosage Androgen Antagonists - pharmacology Animals Antineoplastic Combined Chemotherapy Protocols - pharmacology BCG Vaccine - administration & dosage BCG Vaccine - genetics BCG Vaccine - pharmacology Cell Line, Tumor Cell Movement - drug effects Cell Survival - drug effects Curcumin - administration & dosage Curcumin - analogs & derivatives Curcumin - pharmacology Disease Progression Drug Synergism Female Flutamide - administration & dosage Flutamide - analogs & derivatives Flutamide - pharmacology Gene Expression - drug effects Humans Integrin alpha5beta1 - genetics Interleukin-6 - genetics Macrophages - drug effects Mice Receptors, Androgen - metabolism Reverse Transcriptase Polymerase Chain Reaction Treatment Outcome Urinary Bladder Neoplasms - drug therapy Urinary Bladder Neoplasms - genetics Urinary Bladder Neoplasms - metabolism
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