High-throughput determination of octanol/water partition coefficients using a shake-flask method and novel two-phase solvent system

A high-throughput method for determining the octanol/water partition coefficient (P(o/w)) of a large variety of compounds exhibiting a wide range in hydrophobicity was established. The method combines a simple shake-flask method with a novel two-phase solvent system comprising an acetonitrile-phosph...

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Veröffentlicht in:	Journal of pharmaceutical and biomedical analysis 2016-01, Vol.117, p.338-344
Hauptverfasser:	Morikawa, Go, Suzuka, Chihiro, Shoji, Atsushi, Shibusawa, Yoichi, Yanagida, Akio
Format:	Artikel
Sprache:	eng
Schlagworte:	Chromatography, High Pressure Liquid - methods High-Throughput Screening Assays - instrumentation High-Throughput Screening Assays - methods Octanols - analysis Octanols - chemistry Solvents - analysis Solvents - chemistry Water - analysis Water - chemistry
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