Thrombocytosis and Raised CRP Levels Predicts Advanced Stage in Esophageal Carcinoma
Purpose The significance of thrombocytosis and raised C-reactive protein (CRP) as prognostic markers in esophageal cancer is unclear. Methods We prospectively studied 50 consecutive patients with esophageal cancer and analyzed the relation of preoperative platelet count and CRP levels with the clini...
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| Veröffentlicht in: | Journal of gastrointestinal cancer 2015-12, Vol.46 (4), p.350-355 |
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| creator | Verma, G. R. Thiagarajan, S. Gupta, Rahul Kaman, Lileshwar Das, Reena Kochhar, Rakesh Sinha, S. K. |
| description | Purpose
The significance of thrombocytosis and raised C-reactive protein (CRP) as prognostic markers in esophageal cancer is unclear.
Methods
We prospectively studied 50 consecutive patients with esophageal cancer and analyzed the relation of preoperative platelet count and CRP levels with the clinico-pathological characteristics and stage of the disease. The platelet count of 319 × 10
9
/L for thrombocytosis and CRP level >6 mg/dl were taken as cut-off values.
Results
The incidence of thrombocytosis as well as raised CRP level was 50 %. Eighty percent of patients with thrombocytosis had raised CRP levels. None of patients with early disease (stage I) had thrombocytosis while patients with advanced stage were associated with thrombocytosis, 81.81 % in stage III and 100 % in stage IV (
p
|
| doi_str_mv | 10.1007/s12029-015-9750-z |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1731781924</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1731781924</sourcerecordid><originalsourceid>FETCH-LOGICAL-c325z-ae8b534e88d4eb05b298d830408e341e7c1acabba9c28ac785d957f84fa9d6de3</originalsourceid><addsrcrecordid>eNp9kE1rwjAYx8PYmO7lA-wyctylW5KmbXqU4l5AmDh3DmnyVCtt4xIV9NMvUudxp-cP_xd4fgg9UPJMCclePGWE5RGhSZRnCYkOF2hIc06jNI3Ty7NmYoBuvF8RkvKE0ms0YGkoUs6GaD5fOtuWVu831tceq87gmao9GFzMpngCO2g8njowtd54PDI71elgfm3UAnDd4bG362XQqsGFcrrubKvu0FWlGg_3p3uLvl_H8-I9mny-fRSjSaRjlhwiBaJMYg5CGA4lSUqWCyNiwomAmFPINFValaXKNRNKZyIxeZJVglcqN6mB-BY99btrZ3-24Deyrb2GplEd2K2XNItpJmjOeIjSPqqd9d5BJdeubpXbS0rkEabsYcoAUx5hykPoPJ7mt2UL5tz4oxcCrA_4YHULcHJlt64LL_-z-gtKHIAs</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1731781924</pqid></control><display><type>article</type><title>Thrombocytosis and Raised CRP Levels Predicts Advanced Stage in Esophageal Carcinoma</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Verma, G. R. ; Thiagarajan, S. ; Gupta, Rahul ; Kaman, Lileshwar ; Das, Reena ; Kochhar, Rakesh ; Sinha, S. K.</creator><creatorcontrib>Verma, G. R. ; Thiagarajan, S. ; Gupta, Rahul ; Kaman, Lileshwar ; Das, Reena ; Kochhar, Rakesh ; Sinha, S. K.</creatorcontrib><description>Purpose
The significance of thrombocytosis and raised C-reactive protein (CRP) as prognostic markers in esophageal cancer is unclear.
Methods
We prospectively studied 50 consecutive patients with esophageal cancer and analyzed the relation of preoperative platelet count and CRP levels with the clinico-pathological characteristics and stage of the disease. The platelet count of 319 × 10
9
/L for thrombocytosis and CRP level >6 mg/dl were taken as cut-off values.
Results
The incidence of thrombocytosis as well as raised CRP level was 50 %. Eighty percent of patients with thrombocytosis had raised CRP levels. None of patients with early disease (stage I) had thrombocytosis while patients with advanced stage were associated with thrombocytosis, 81.81 % in stage III and 100 % in stage IV (
p
< 0.001). The incidence of elevated CRP levels has shown progressive linear co-relation with the stage of carcinoma, i.e., 0 % in pathological stage I, 16.67 % in stage II, 45.45 % in stage III, and 100 % in stage IV disease (
p
= 0.011). Patients with thrombocytosis and patients with raised CRP were associated with pathological nodal metastases in 84.61 % cases (
p
0.005) and 61.53 % (
p
0.030), respectively.
Conclusion
Thrombocytosis alone or in combination with raised CRP had progressive linear relation with the stage of esophageal carcinoma.</description><identifier>ISSN: 1941-6628</identifier><identifier>EISSN: 1941-6636</identifier><identifier>DOI: 10.1007/s12029-015-9750-z</identifier><identifier>PMID: 26202142</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Adenocarcinoma - classification ; Adenocarcinoma - pathology ; Adult ; Aged ; Biomarkers, Tumor - blood ; C-Reactive Protein - metabolism ; Cancer Research ; Carcinoma, Squamous Cell - classification ; Carcinoma, Squamous Cell - pathology ; Esophageal Neoplasms - classification ; Esophageal Neoplasms - pathology ; Female ; Follow-Up Studies ; Gastroenterology ; Humans ; Internal Medicine ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Neoplasm Staging ; Oncology ; Original Research ; Platelet Count ; Prognosis ; Prospective Studies ; Radiotherapy ; Retrospective Studies ; Thrombocytosis - complications</subject><ispartof>Journal of gastrointestinal cancer, 2015-12, Vol.46 (4), p.350-355</ispartof><rights>Springer Science+Business Media New York 2015</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c325z-ae8b534e88d4eb05b298d830408e341e7c1acabba9c28ac785d957f84fa9d6de3</citedby><cites>FETCH-LOGICAL-c325z-ae8b534e88d4eb05b298d830408e341e7c1acabba9c28ac785d957f84fa9d6de3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12029-015-9750-z$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12029-015-9750-z$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26202142$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Verma, G. R.</creatorcontrib><creatorcontrib>Thiagarajan, S.</creatorcontrib><creatorcontrib>Gupta, Rahul</creatorcontrib><creatorcontrib>Kaman, Lileshwar</creatorcontrib><creatorcontrib>Das, Reena</creatorcontrib><creatorcontrib>Kochhar, Rakesh</creatorcontrib><creatorcontrib>Sinha, S. K.</creatorcontrib><title>Thrombocytosis and Raised CRP Levels Predicts Advanced Stage in Esophageal Carcinoma</title><title>Journal of gastrointestinal cancer</title><addtitle>J Gastrointest Canc</addtitle><addtitle>J Gastrointest Cancer</addtitle><description>Purpose
The significance of thrombocytosis and raised C-reactive protein (CRP) as prognostic markers in esophageal cancer is unclear.
Methods
We prospectively studied 50 consecutive patients with esophageal cancer and analyzed the relation of preoperative platelet count and CRP levels with the clinico-pathological characteristics and stage of the disease. The platelet count of 319 × 10
9
/L for thrombocytosis and CRP level >6 mg/dl were taken as cut-off values.
Results
The incidence of thrombocytosis as well as raised CRP level was 50 %. Eighty percent of patients with thrombocytosis had raised CRP levels. None of patients with early disease (stage I) had thrombocytosis while patients with advanced stage were associated with thrombocytosis, 81.81 % in stage III and 100 % in stage IV (
p
< 0.001). The incidence of elevated CRP levels has shown progressive linear co-relation with the stage of carcinoma, i.e., 0 % in pathological stage I, 16.67 % in stage II, 45.45 % in stage III, and 100 % in stage IV disease (
p
= 0.011). Patients with thrombocytosis and patients with raised CRP were associated with pathological nodal metastases in 84.61 % cases (
p
0.005) and 61.53 % (
p
0.030), respectively.
Conclusion
Thrombocytosis alone or in combination with raised CRP had progressive linear relation with the stage of esophageal carcinoma.</description><subject>Adenocarcinoma - classification</subject><subject>Adenocarcinoma - pathology</subject><subject>Adult</subject><subject>Aged</subject><subject>Biomarkers, Tumor - blood</subject><subject>C-Reactive Protein - metabolism</subject><subject>Cancer Research</subject><subject>Carcinoma, Squamous Cell - classification</subject><subject>Carcinoma, Squamous Cell - pathology</subject><subject>Esophageal Neoplasms - classification</subject><subject>Esophageal Neoplasms - pathology</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Gastroenterology</subject><subject>Humans</subject><subject>Internal Medicine</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Neoplasm Staging</subject><subject>Oncology</subject><subject>Original Research</subject><subject>Platelet Count</subject><subject>Prognosis</subject><subject>Prospective Studies</subject><subject>Radiotherapy</subject><subject>Retrospective Studies</subject><subject>Thrombocytosis - complications</subject><issn>1941-6628</issn><issn>1941-6636</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1rwjAYx8PYmO7lA-wyctylW5KmbXqU4l5AmDh3DmnyVCtt4xIV9NMvUudxp-cP_xd4fgg9UPJMCclePGWE5RGhSZRnCYkOF2hIc06jNI3Ty7NmYoBuvF8RkvKE0ms0YGkoUs6GaD5fOtuWVu831tceq87gmao9GFzMpngCO2g8njowtd54PDI71elgfm3UAnDd4bG362XQqsGFcrrubKvu0FWlGg_3p3uLvl_H8-I9mny-fRSjSaRjlhwiBaJMYg5CGA4lSUqWCyNiwomAmFPINFValaXKNRNKZyIxeZJVglcqN6mB-BY99btrZ3-24Deyrb2GplEd2K2XNItpJmjOeIjSPqqd9d5BJdeubpXbS0rkEabsYcoAUx5hykPoPJ7mt2UL5tz4oxcCrA_4YHULcHJlt64LL_-z-gtKHIAs</recordid><startdate>201512</startdate><enddate>201512</enddate><creator>Verma, G. R.</creator><creator>Thiagarajan, S.</creator><creator>Gupta, Rahul</creator><creator>Kaman, Lileshwar</creator><creator>Das, Reena</creator><creator>Kochhar, Rakesh</creator><creator>Sinha, S. K.</creator><general>Springer US</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201512</creationdate><title>Thrombocytosis and Raised CRP Levels Predicts Advanced Stage in Esophageal Carcinoma</title><author>Verma, G. R. ; Thiagarajan, S. ; Gupta, Rahul ; Kaman, Lileshwar ; Das, Reena ; Kochhar, Rakesh ; Sinha, S. K.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c325z-ae8b534e88d4eb05b298d830408e341e7c1acabba9c28ac785d957f84fa9d6de3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adenocarcinoma - classification</topic><topic>Adenocarcinoma - pathology</topic><topic>Adult</topic><topic>Aged</topic><topic>Biomarkers, Tumor - blood</topic><topic>C-Reactive Protein - metabolism</topic><topic>Cancer Research</topic><topic>Carcinoma, Squamous Cell - classification</topic><topic>Carcinoma, Squamous Cell - pathology</topic><topic>Esophageal Neoplasms - classification</topic><topic>Esophageal Neoplasms - pathology</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Gastroenterology</topic><topic>Humans</topic><topic>Internal Medicine</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Neoplasm Staging</topic><topic>Oncology</topic><topic>Original Research</topic><topic>Platelet Count</topic><topic>Prognosis</topic><topic>Prospective Studies</topic><topic>Radiotherapy</topic><topic>Retrospective Studies</topic><topic>Thrombocytosis - complications</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Verma, G. R.</creatorcontrib><creatorcontrib>Thiagarajan, S.</creatorcontrib><creatorcontrib>Gupta, Rahul</creatorcontrib><creatorcontrib>Kaman, Lileshwar</creatorcontrib><creatorcontrib>Das, Reena</creatorcontrib><creatorcontrib>Kochhar, Rakesh</creatorcontrib><creatorcontrib>Sinha, S. K.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of gastrointestinal cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Verma, G. R.</au><au>Thiagarajan, S.</au><au>Gupta, Rahul</au><au>Kaman, Lileshwar</au><au>Das, Reena</au><au>Kochhar, Rakesh</au><au>Sinha, S. K.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Thrombocytosis and Raised CRP Levels Predicts Advanced Stage in Esophageal Carcinoma</atitle><jtitle>Journal of gastrointestinal cancer</jtitle><stitle>J Gastrointest Canc</stitle><addtitle>J Gastrointest Cancer</addtitle><date>2015-12</date><risdate>2015</risdate><volume>46</volume><issue>4</issue><spage>350</spage><epage>355</epage><pages>350-355</pages><issn>1941-6628</issn><eissn>1941-6636</eissn><abstract>Purpose
The significance of thrombocytosis and raised C-reactive protein (CRP) as prognostic markers in esophageal cancer is unclear.
Methods
We prospectively studied 50 consecutive patients with esophageal cancer and analyzed the relation of preoperative platelet count and CRP levels with the clinico-pathological characteristics and stage of the disease. The platelet count of 319 × 10
9
/L for thrombocytosis and CRP level >6 mg/dl were taken as cut-off values.
Results
The incidence of thrombocytosis as well as raised CRP level was 50 %. Eighty percent of patients with thrombocytosis had raised CRP levels. None of patients with early disease (stage I) had thrombocytosis while patients with advanced stage were associated with thrombocytosis, 81.81 % in stage III and 100 % in stage IV (
p
< 0.001). The incidence of elevated CRP levels has shown progressive linear co-relation with the stage of carcinoma, i.e., 0 % in pathological stage I, 16.67 % in stage II, 45.45 % in stage III, and 100 % in stage IV disease (
p
= 0.011). Patients with thrombocytosis and patients with raised CRP were associated with pathological nodal metastases in 84.61 % cases (
p
0.005) and 61.53 % (
p
0.030), respectively.
Conclusion
Thrombocytosis alone or in combination with raised CRP had progressive linear relation with the stage of esophageal carcinoma.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>26202142</pmid><doi>10.1007/s12029-015-9750-z</doi><tpages>6</tpages></addata></record> |
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| subjects | Adenocarcinoma - classification Adenocarcinoma - pathology Adult Aged Biomarkers, Tumor - blood C-Reactive Protein - metabolism Cancer Research Carcinoma, Squamous Cell - classification Carcinoma, Squamous Cell - pathology Esophageal Neoplasms - classification Esophageal Neoplasms - pathology Female Follow-Up Studies Gastroenterology Humans Internal Medicine Male Medicine Medicine & Public Health Middle Aged Neoplasm Staging Oncology Original Research Platelet Count Prognosis Prospective Studies Radiotherapy Retrospective Studies Thrombocytosis - complications |
| title | Thrombocytosis and Raised CRP Levels Predicts Advanced Stage in Esophageal Carcinoma |
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