Voltage-gated, margatoxin-sensitive potassium channels, but not calcium-gated, iberiotoxin-sensitive potassium channels modulate acetylcholine release in rat striatal slices

We evaluated the effects of iberiotoxin, an inhibitor of Slo-type Ca 2+-activated potassium channels and two inhibitors of Shaker-type voltage-gated potassium channels margatoxin and dendrotoxin on acetylcholine outflow in rat striatal slices. An in vitro perfusion with 100 nM margatoxin or dendroto...

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Veröffentlicht in:	Neuroscience letters 1999-03, Vol.263 (2), p.208-210
Hauptverfasser:	Fischer, Hanspeter S, Saria, Alois
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholine - metabolism Acetylcholine release Animals Biological and medical sciences Central nervous system Central neurotransmission. Neuromudulation. Pathways and receptors Corpus Striatum - drug effects Corpus Striatum - physiology Dendrotoxin Elapid Venoms - pharmacology Fundamental and applied biological sciences. Psychology Iberiotoxin In vitro perfusion In Vitro Techniques Kv1.2 Potassium Channel Large-Conductance Calcium-Activated Potassium Channel alpha Subunits Large-Conductance Calcium-Activated Potassium Channels Margatoxin N-Methylaspartate - pharmacology Neurotoxins - pharmacology Peptides - pharmacology Potassium channels Potassium Channels - drug effects Potassium Channels - physiology Potassium Channels, Calcium-Activated Potassium Channels, Voltage-Gated Rats Scorpion Venoms - pharmacology Shaker Superfamily of Potassium Channels Striatum slices Vertebrates: nervous system and sense organs
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