Phase 1 safety and immune response studies of a DNA vaccine encoding hepatitis B surface antigen delivered by a gene delivery device

This study was designed to determine the safety and immunogenicity in volunteers of a DNA vaccine consisting of a plasmid encoding hepatitis B surface antigen delivered by the PowderJect XR1 gene delivery system into human skin. Seven healthy adult volunteers received two immunizations at one of thr...

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Veröffentlicht in:	Vaccine 1999-07, Vol.17 (22), p.2826-2829
Hauptverfasser:	Tacket, Carol O, Roy, Michael J, Widera, Georg, Swain, William F, Broome, Stephanie, Edelman, Robert
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Antibodies, Viral - blood Biological and medical sciences DNA vaccine DNA, Viral - adverse effects DNA, Viral - therapeutic use Drug Delivery Systems - adverse effects Epidemiology. Vaccinations Fundamental and applied biological sciences. Psychology General aspects Hepatitis B - immunology Hepatitis B - prevention & control Hepatitis B Surface Antigens - genetics Hepatitis B Surface Antigens - immunology Hepatitis B vaccine Hepatitis B Vaccines - adverse effects Hepatitis B Vaccines - therapeutic use Hepatitis B virus Hepatitis B virus - genetics Hepatitis B virus - immunology Humans Immunity, Mucosal - immunology Infectious diseases Injections, Intradermal - adverse effects Medical sciences Microbiology Middle Aged Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies Vaccines, DNA - adverse effects Vaccines, DNA - therapeutic use Virology
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