Genetic Alteration of Poly(ADP-ribose) Polymerase-1 in Human Germ Cell Tumors

Accumulated evidence suggests that poly(ADP-ribose) polymerase-1 (PARP-1) is involved in DNA repair, cell-death induction, differentiation and tumorigenesis. Parp-1 deficiency also induces trophoblast differentiation from mouse embryonic stem cells during teratocarcinoma-like tumor formation. To und...

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Veröffentlicht in:	Japanese journal of clinical oncology 2005-02, Vol.35 (2), p.97-102
Hauptverfasser:	Shiokawa, Motoko, Masutani, Mitsuko, Fujihara, Hisako, Ueki, Keisuke, Nishikawa, Ryo, Sugimura, Takashi, Kubo, Harumi, Nakagama, Hitoshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Base Sequence brain Brain Neoplasms - etiology Brain Neoplasms - genetics Brain Neoplasms - metabolism germ cell tumor Germ-Line Mutation Germinoma - etiology Germinoma - genetics Germinoma - metabolism Humans Male mutations poly(ADP-ribose) polymerase-1 Poly(ADP-ribose) Polymerases - genetics Poly(ADP-ribose) Polymerases - metabolism Polymorphism, Single Nucleotide SNP Testicular Neoplasms - etiology Testicular Neoplasms - genetics Testicular Neoplasms - metabolism
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