Enantioselective Synthesis of Hemiaminals via Pd-Catalyzed C–N Coupling with Chiral Bisphosphine Mono-oxides

Enantioselective Synthesis of Hemiaminals via Pd-Catalyzed C–N Coupling with Chiral Bisphosphine Mono-oxides

A novel approach to hemiaminal synthesis via palladium-catalyzed C–N coupling with chiral bisphosphine mono-oxides is described. This efficient new method exhibits a broad scope, provides a highly efficient synthesis of HCV drug candidate elbasvir, and has been applied to the synthesis of chiral N,N...

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Veröffentlicht in:Journal of the American Chemical Society 2015-11, Vol.137 (43), p.13728-13731
Hauptverfasser: Li, Hongming, Belyk, Kevin M, Yin, Jingjun, Chen, Qinghao, Hyde, Alan, Ji, Yining, Oliver, Steven, Tudge, Matthew T, Campeau, Louis-Charles, Campos, Kevin R
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container_end_page 13731
container_issue 43
container_start_page 13728
container_title Journal of the American Chemical Society
container_volume 137
creator Li, Hongming
Belyk, Kevin M
Yin, Jingjun
Chen, Qinghao
Hyde, Alan
Ji, Yining
Oliver, Steven
Tudge, Matthew T
Campeau, Louis-Charles
Campos, Kevin R
description A novel approach to hemiaminal synthesis via palladium-catalyzed C–N coupling with chiral bisphosphine mono-oxides is described. This efficient new method exhibits a broad scope, provides a highly efficient synthesis of HCV drug candidate elbasvir, and has been applied to the synthesis of chiral N,N-acetals.
doi_str_mv 10.1021/jacs.5b05934
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title Enantioselective Synthesis of Hemiaminals via Pd-Catalyzed C–N Coupling with Chiral Bisphosphine Mono-oxides
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