Acetyl-l-carnitine administration increases insulin-like growth factor 1 levels in asymptomatic HIV-1-infected subjects : Correlation with its suppressive effect on lymphocyte apoptosis and ceramide generation

The aim of this study was to investigate the impact of long-term acetyl-L-carnitine administration on CD4 and CD8 absolute counts, apoptosis, and insulin-like growth factor-1 (IGF-1) serum levels in HIV-1-infected subjects. The generation of cell-associated ceramide and HIV-1 viremia were also inves...

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Veröffentlicht in:	Clinical immunology (Orlando, Fla.) Fla.), 1999-07, Vol.92 (1), p.103-110
Hauptverfasser:	DI MARZIO, L, MORETTI, S, D'ALO, S, ZAZZERONI, F, MARCELLINI, S, SMACCHIA, C, ALESSE, E, CIFONE, M. G, DE SIMONE, C
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcarnitine - administration & dosage Acetylcarnitine - therapeutic use Acetylcarnitine - toxicity Adult Apoptosis - drug effects Biological and medical sciences CD4-Positive T-Lymphocytes - cytology CD8-Positive T-Lymphocytes - cytology Ceramides - biosynthesis Dose-Response Relationship, Drug Growth Hormone - blood HIV Infections - blood HIV Infections - drug therapy HIV Seropositivity - drug therapy HIV-1 Human immunodeficiency virus 1 Humans Immunomodulators Insulin-Like Growth Factor Binding Protein 3 - blood Insulin-Like Growth Factor I - metabolism Lymphocytes - cytology Male Medical sciences Middle Aged Pharmacology. Drug treatments Serum Albumin - analysis
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