Lack of correlation between residual radiation-induced DNA damage, in keratinocytes assayed directly from skin, and late radiotherapy reactions in breast cancer patients

Purpose: To study the relationship between the severity of late reactions to radiotherapy in breast cancer patients, and the extent of residual radiation-induced DNA damage, using a rapid assay of keratinocytes obtained directly from skin biopsies. Methods and Materials: A review was made of 32 pati...

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Veröffentlicht in:	International journal of radiation oncology, biology, physics biology, physics, 1999-02, Vol.43 (3), p.481-487
Hauptverfasser:	Kiltie, Anne E, Barber, James B.P, Swindell, Ric, Ryan, Anderson J, West, Catharine M.L, Hendry, Jolyon H, Magee, Brian
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Analysis of Variance Biological and medical sciences Biopsy Breast - pathology Breast Neoplasms - pathology Breast Neoplasms - radiotherapy Carcinoma - pathology Carcinoma - radiotherapy DNA - radiation effects DNA Damage Dose Fractionation, Radiation Female Genital system. Mammary gland Gynecology. Andrology. Obstetrics Humans Keratinocytes Keratinocytes - radiation effects Mammary gland diseases Medical sciences Middle Aged Normal tissues Predictive assays Predictive Value of Tests Radiation Injuries - pathology Radiosensitivity Radiotherapy Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) Retrospective Studies Severity of Illness Index Skin - pathology Skin - radiation effects Tumors
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