alpha -Conotoxins ImI and ImII Target Distinct Regions of the Human alpha 7 Nicotinic Acetylcholine Receptor and Distinguish Human Nicotinic Receptor Subtypes

The Conus peptides alpha -conotoxin ImI ( alpha -ImI) and ImII ( alpha -ImII) differ by only three of 11 residues in their primary sequences and yet are shown to inhibit the human alpha 7 nicotinic acetylcholine receptor (nAChR) by targeting different sites. Mutations at both faces of the classical...

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Veröffentlicht in:	Biochemistry (Easton) 2004-12, Vol.43 (51), p.16019-16026
Hauptverfasser:	Ellison, M, Gao, Fan, Wang, Hai-Long, Sine, S M, McIntosh, J M, Olivera, B M
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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